Iopamidol

Iopamidol (INN, trade names Iopamiro, Isovue, Iopamiron, and Niopam) is a nonionic, low-osmolar iodinated contrast agent, developed by Bracco.

Iopamidol
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • US: B (No risk in non-human studies)
    Routes of
    administration    		Intravascular
    ATC code
    Legal status
    Legal status
    Identifiers
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.056.430
    Chemical and physical data
    FormulaC17H22I3N3O8
    Molar mass777.08 g/mol g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    It is available in various concentrations, from 200 to 370 mgI/mL.

    Clinical uses

    Iopamidol is primarily used in the following:[1]

    • Angiography throughout the cardiovascular system, including cerebral and peripheral arteriography, coronary arteriography and ventriculography, pediatric angiocardiography, selective visceral arteriography and aortography, peripheral venography (phlebography)
    • Adult and pediatric intravenous excretory urography and intravenous adult and pediatric contrast enhancement of computed tomographic (CECT) head and body imaging

    Nursing considerations: Early generations of IV contrast carried considerable nephrotoxicity, necessitating continual assessment of renal function. IV and PO fluids are encouraged post operation to facilitate excretion of contrast. There is a common myth in medicine and nursing that patients may be allergic to iodine in contrast, however, there is considerable evidence to the contrary. This is likely a carryover of confusion regarding contrast-reactions to early generations of IV contrast which were of sufficiently high osmolarity to induce degranulation of mast cells which manifests clinically as similar in appearance to anaphlylaxis due to massive release of histamine. There is no need to assess patients for allergies to iodine or shellfish as allergy to iodine is physiologically impossible in a hemodynamically stable patient. Allergy to iodine would immediately manifest as overwhelming anaphylaxis due to presence of iodine in triiodothyronine(T3) and thyroxine(T4). Shellfish allergies have been demonstrated to be due to proteins produced by the organisms, not due to iodine.

    References
    1. Bracco Diagnostic Inc. (April 2004). "Iopamidol (Isovue) prescribing information (revised April 2004)". DailyMed. U.S. National Library of Medicine. Retrieved 2008-03-28.


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