Dobrava-Belgrade orthohantavirus

Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated from yellow-necked mice (Apodemus flavicollis) found in Dobrava Village, Slovenia, Yugoslavia.[3] It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.[4]

Dobrava-Belgrade orthohantavirus
Virus classification
(unranked): Virus
Realm: Riboviria
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Subfamily: Mammantavirinae
Genus: Orthohantavirus
Species: Dobrava-Belgrade orthohantavirus
Member virus[1]
Synonyms[2]
  • Dobrava-Belgrade hantavirus
  • Dobrava-Belgrade virus

Reservoir

Dobrava virus and the variants of Dobrava-Belgrade virus have been found in the yellow-necked mouse (Apodemus flavicollis) virus genotype Dobrava, the Striped field mouse (Apodemus agrarius) virus genotype Kurkino, and Black Sea field mouse (Apodemus ponticus) virus genotype Sochi.

Morbidity and mortality

The fatality rate is 12%, making Dobrava virus the most life-threatening hantavirus disease in Europe. Variant DOBV genotypes have different degrees of pathogenicity.[5]

See also

References
  1. Briese, Thomas (July 18, 2016). "In the genus Hantavirus (proposed family Hanta viridae , proposed order Bunyavirales ), c reate 24 new species, abolish 7 species , change the demarcation criteria , and change the name of the genus to Orthohantavirus ; likewise, rename its constit uent species" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved 30 January 2019.
  2. "ICTV Taxonomy history: Dobrava-Belgrade orthohantavirus" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 30 January 2019.
  3. Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (Oct 1992). "Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia". J Med Virol. 38 (2): 132–7. doi:10.1002/jmv.1890380211. PMID 1360999.
  4. Schlegel Mathias; Klempa Boris; Auste Brita; Bemmann Margrit; Schmidt-Chanasit Jonas; Büchner Thomas; Groschup Martin H.; Meier Markus; Balkema-Buschmann Anne; Zoller Hinrich; Krüger Detlev H.; Ulrich Rainer G. (2009). "Dobrava-Belgrade Virus Spillover Infections, Germany". Dispatch. 15 (12).
  5. Papa A (Aug 2012). "Dobrava-Belgrade virus: phylogeny, epidemiology, disease". Antiviral Res. 95 (2): 104–17. doi:10.1016/j.antiviral.2012.05.011. PMID 22659378.
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