Seoul orthohantavirus

Seoul orthohantavirus (SEOV) is a member of the Orthohantavirus family of rodent-borne viruses and can cause Hantavirus hemorrhagic fever with renal syndrome.[1][2]

Seoul orthohantavirus
Virus classification
(unranked): Virus
Realm: Riboviria
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Subfamily: Mammantavirinae
Genus: Orthohantavirus
Species:
Seoul orthohantavirus

Seoul virus is found in Rattus species rats, most commonly Rattus norvegicus, but occasionally Rattus rattus[3]. Rats do not show physiological symptoms when carrying the virus, but humans can be infected through exposure to infectious body fluids (blood, saliva, urine), exposure to aerosolized rat feces, or bites from infected rats.[1] There is no evidence of human-to-human transmission of SEOV.[4]

Seoul orthohantavirus was first described by Dr. Lee Ho-Wang (Ho-Wang Lee), a Korean virologist. It was originally thought that hemorrhagic fever was caused by contact with field mice (Genus Apodemus), but Dr. Lee found that it could also be caused by contact with brown or Norway rats (Rattus norvegicus). As the infection was first found in an apartment in Seoul, the virus was named "Seoul Virus".


Virology

Virus Structure and Genome

SEOV, along with all other hantaviruses, is a negative sense, single-stranded RNA virus. Its genome has three different segments: S (small), M (medium), and L (large)[5]. The virus is pleomorphic, having various shapes, but often is seen as spherical, with its two surface glycoproteins arranged in rows. Inside this sphere, the three RNA segments are arranged as circles, coated in the virus' N (nucleocapsid) protein and attached to the L protein. The 5' and 3' ends of the genome segments match up, creating a panhandle structure. This base pairing occurs in all hantavirus species, with the panhandle structure and sequence being unique to each particular species, of course with some similarities and overlap between species, including an eight nucleotide consensus sequence[6][5].

Viral Proteins

There are four major viral proteins, the two surface glycoproteins (Gn and Gc), the nucleocapsid protein (N), and the viral polymerase (L).

The Gn and Gc proteins exist on the surface of the mature virus as spikes in highly ordered rows, with each spike having for Gn/Gc heterodimers[5][7]. Interactions between the spikes are thought to cause viral budding into the Golgi apparatus[8]. These surface glycoproteins are also responsible for the attachment of the virus to its target host cell. Gn and Gc spikes attach to β3 integrins and co-receptors on the target cell surface[7][9].

Epidemiology

Most human infections are recorded in Asia.[4] Human infections account for ~25% of cases of hemorrhagic fever with renal syndrome in Asia.[10]

As of 2015 the virus has been found in wild rats in the Netherlands, and in both rodents and humans in England, Wales, France, Belgium, and Sweden.[1] Rats in New York City are also known reservoirs.[11]

An outbreak of Seoul orthohantavirus infected eleven people in the U.S. states of Illinois, Indiana and Wisconsin from December 2016 to February 2017. Individuals who operated a home-based rat-breeding facility in Wisconsin became ill and were hospitalized. The ill individuals had purchased rats from animal suppliers in Wisconsin and Illinois. Investigators traced the infection to two Illinois ratteries and identified six additional people who tested positive for Seoul virus. All these individuals recovered. Further investigation by the Centers for Disease Control and Prevention revealed that potentially infected rodents may have traveled to the states of Alabama, Arkansas, Colorado, Illinois, Indiana, Iowa, Louisiana, Michigan, Minnesota, Missouri, North Dakota, South Carolina, Tennessee, Utah, and Wisconsin.[12][4] Cases were also reported in Ontario in February 2016.[13]

Clinical features

The patient will develop high grade fever, sweating, chills, abdominal pain, joint pain, red eye, nausea, vomiting, one or multiple rash(es) and/or a headache.

The symptoms can appear quickly, the patient will suffer from severe symptoms which may lead to death. To prevent from contracting this virus, avoid contact with wild rats and only adopt pet rats from renown sources who have tested their rats by serology in order to confirm their colony does not carry this virus. Proof of testing should be public and offered to anyone who asks for it.

See also

References
  1. Goeijenbier M; et al. (May 2015). "Seoul hantavirus in brown rats in the Netherlands: implications for physicians—Epidemiology, clinical aspects, treatment and diagnostics". Neth. J. Med. 73 (4): 155–60. PMID 25968286.
  2. US Centers for Disease Control. Virology, Hantaviruses Page last reviewed: August 29, 2012.
  3. Jonsson, Colleen B.; Figueiredo, Luiz Tadeu Moraes; Vapalahti, Olli (2010-04-01). "A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease". Clinical Microbiology Reviews. 23 (2): 412–441. doi:10.1128/CMR.00062-09. ISSN 0893-8512. PMID 20375360.
  4. US Centers for Disease Control. Multi-state Outbreak of Seoul Virus Updated January 19, 2017.
  5. Knipe, David M. (2015). Fields Virology. Wolters Kluwer. ISBN 1-4511-0563-0. OCLC 956639500.
  6. Mir, M. A.; Brown, B.; Hjelle, B.; Duran, W. A.; Panganiban, A. T. (2006-11-01). "Hantavirus N Protein Exhibits Genus-Specific Recognition of the Viral RNA Panhandle". Journal of Virology. 80 (22): 11283–11292. doi:10.1128/JVI.00820-06. ISSN 0022-538X. PMID 16971445.
  7. Cifuentes-Muñoz, Nicolás; Salazar-Quiroz, Natalia; Tischler, Nicole (2014-04-21). "Hantavirus Gn and Gc Envelope Glycoproteins: Key Structural Units for Virus Cell Entry and Virus Assembly". Viruses. 6 (4): 1801–1822. doi:10.3390/v6041801. ISSN 1999-4915.
  8. Acuna, R.; Cifuentes-Munoz, N.; Marquez, C. L.; Bulling, M.; Klingstrom, J.; Mancini, R.; Lozach, P.-Y.; Tischler, N. D. (2013-12-11). "Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles". Journal of Virology. 88 (4): 2344–2348. doi:10.1128/jvi.03118-13. ISSN 0022-538X.
  9. Krautkramer, E.; Zeier, M. (2008-02-27). "Hantavirus Causing Hemorrhagic Fever with Renal Syndrome Enters from the Apical Surface and Requires Decay-Accelerating Factor (DAF/CD55)". Journal of Virology. 82 (9): 4257–4264. doi:10.1128/jvi.02210-07. ISSN 0022-538X.
  10. Yao LS, Qin CF, Pu Y, Zhang XL, Liu YX, Liu Y, Cao XM, Deng YQ, Wang J, Hu KX, Xu BL (2012). "Complete genome sequence of Seoul virus isolated from Rattus norvegicus in the Democratic People's Republic of Korea". J. Virol. 86 (24): 13853. doi:10.1128/JVI.02668-12. PMC 3503101. PMID 23166256.
  11. Firth, C (2014). "Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City". mBio. 5 (5): e01933–14. doi:10.1128/mBio.01933-14. PMC 4205793. PMID 25316698.
  12. "Multi-state Outbreak of Seoul Virus | Hantavirus | DHCPP | CDC". www.cdc.gov. Retrieved 2017-02-14.
  13. "3 people in Ontario contract Seoul virus spread by rats". CBC News. The Canadian Press. 1 March 2017. Retrieved 4 March 2017.

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