Complement component 9

C9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FMW
Identifiers
Aliases	C9, ARMD15, C9D, complement component 9, complement C9
External IDs	OMIM: 120940 MGI: 1098282 HomoloGene: 74406 GeneCards: C9
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	39,424,868 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	6,498,751 bp[2]
Gene ontology
Molecular function	• growth factor activity;
Cellular component	• integral component of membrane; • extracellular region; • integral component of plasma membrane; • extracellular exosome; • blood microparticle; • membrane; • membrane attack complex; • extracellular space; • cytosol; • plasma membrane; • other organism cell membrane; • other organism membrane;
Biological process	• cytolysis; • regulation of complement activation; • hemolysis by symbiont of host erythrocytes; • Alternative complement pathway; • immune response; • Classical complement pathway; • immune system process; • innate immune system; • cell killing; • protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	735
	12279
	ENSG00000113600
	ENSMUSG00000022149
	P02748
	P06683
	NM_001737
	NM_013485; NM_001368420; NM_001368421
	NP_001728
	NP_038513; NP_001355349; NP_001355350
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system.[5] C9 is a member of the complement membrane attack complex (MAC) and induces pores on cell membranes, causing lysis. There are 10-16 molecules of C9 in a single membrane attack complex (MAC), along with one of each of the complement components C5b, C6, C7 and C8.[6]

References

GRCh38: Ensembl release 89: ENSG00000113600 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022149 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". J. Immunol. 125 (5): 2252–7. PMID 7430628.
Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease. New York: Garland Science. Retrieved 29 December 2017.

External links

Complement+9 at the US National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Complement component C9

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113600 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022149 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7430628-5] Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". J. Immunol. 125 (5): 2252–7. PMID 7430628.

[Janeway_2001-6] Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease. New York: Garland Science. Retrieved 29 December 2017.