Complement component 7

Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

C7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC7, complement component 7, complement C7
External IDsOMIM: 217070 MGI: 88235 HomoloGene: 489 GeneCards: C7
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p13.1Start40,909,497 bp[1]
End40,984,643 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

730

109828

Ensembl

ENSG00000112936

ENSMUSG00000079105

UniProt

P10643

D3YXF5

RefSeq (mRNA)

NM_000587

NM_001243837

RefSeq (protein)

NP_000578

NP_001230766

Location (UCSC)Chr 5: 40.91 – 40.98 MbChr 15: 4.99 – 5.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

See also
  • Complement+C7 at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.


  1. GRCh38: Ensembl release 89: ENSG00000112936 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000079105 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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