Complement component 7
Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.
|Aliases||C7, complement component 7, complement C7|
|External IDs||OMIM: 217070 MGI: 88235 HomoloGene: 489 GeneCards: C7|
|Location (UCSC)||Chr 5: 40.91 – 40.98 Mb||Chr 15: 4.99 – 5.06 Mb|
Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.
- Complement+C7 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.
- GRCh38: Ensembl release 89: ENSG00000112936 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000079105 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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