Vasa nervorum

Vasa nervorum are small arteries that provide blood supply to peripheral nerves. These vessels supply blood to interior parts of nerves [1] and their coverings.[2]

Associated pathologic conditions

Small vessels like vasa vasorum and vasa nervorum are particularly susceptible to external mechanical compression.[2] A decrease in blood flow through the vasa nervorum has been implicated in the development of diabetic neuropathy. Arteritis of the vasa nervorum leads to mononeuritis multiplex or polyneuropathy.[3] Occlusion of vasa nervorum at the level of the epineurial arterioles leads to ischemia of nerves, leading to vasculitic neuropathy.[3][4] and has been implicated as the cause in a few cases of facial nerve paralysis.[3] During invasive diagnostic or therapeutic procedures, injecting a vasoconstrictor close to a nerve can reduce perfusion to its supplying vessel, risking ischemic nerve injury.[5]


  1. Rohkamm, Reinhard (2004). Color atlas of neurology. Ill. by Manfred Güther. Transl. rev. by Ethan Taub. [Orig. transl.: Suzyon O'Neal Wandrey]. Stuttgart [u.a.]: Thieme. p. 90. ISBN 9781588901910.
  2. Moore, Keith L.; Agur, Anne M.R.; Dalley, Arthur F. (2010). Clinically oriented anatomy (6th ed., [International ed.]. ed.). Philadelphia [etc.]: Lippincott Williams & Wilkins, Wolters Kluwer. p. 50. ISBN 9781605476520.
  3. Imboden, John B.; Stone, John H.; Hellman, David B., eds. (2007). Current rheumatology diagnosis & treatment (2nd ed.). New York ; Toronto: Lange Medical Books/McGraw-Hill, Medical Pub. Division. ISBN 9780071460408.
  4. Said, G (November 1997). "Necrotizing peripheral nerve vasculitis". Neurologic Clinics. 15 (4): 835–48. doi:10.1016/s0733-8619(05)70350-9. PMID 9367967.
  5. Chelly, Jacques E., ed. (2009). Peripheral nerve blocks : a color atlas (3rd ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 214. ISBN 9780781768764.
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