Hematoxylin body

In diagnostic pathology, a hematoxylin body, or LE body, is a dense, homogeneous, basophilic particle, easily stainable with hematoxylin. It consists of degraded nuclear material from an injured cell, along with autoantibodies and a limited amount of cytoplasm.[1][2][3]

Hematoxylin bodies occur in systemic lupus erythematosus. The hematoxylin body may be green, blue, or purple with the Papanicolaou stain and magenta with Romanowsky stains.[4] The material has a positive Feulgen stain reaction, which is typical of DNA.[5] The material may be extracellular or may be ingested by leukocytes, which are then known as LE cells.[2][6][7]

References
  1. Chan JK (2014). "The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology". Int. J. Surg. Pathol. 22 (1): 12–32. doi:10.1177/1066896913517939. PMID 24406626.CS1 maint: Uses authors parameter (link)
  2. Hematoxylin body. Medical Dictionary
  3. Moreland, LW. Rheumatology and Immunology Therapy Springer Berlin Heidelberg 2004 page 384 ISBN 9783540206255 doi:10.1007/3-540-29662-X_1191
  4. Cibas ES, Ducatman BS. Cytology: Diagnostic Principles and Clinical Correlates. Elsevier Health Sciences. 2013. Pages 132-133 ISBN 9781455750795
  5. Hollander JL. Arthritis and allied conditions: a textbook of rheumatology. 1966 Page 100 and 784
  6. Wallace DJ, Hahn B. (editors). Dubois' Lupus Erythematosus. Lippincott Williams & Wilkins, 2007. ISBN 9780781793940
  7. Robbins & Cotran Pathologic Basis of Disease. Vinay Kumar V, Abbas AK, Aster JC. Elsevier Health Sciences, 2014. Edition 9, revised. pages 222 and 225. ISBN 9780323296359
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