Coumermycin A1
Coumermycin A1 is an aminocoumarin [1][2]. Its main target is the ATPase site of the DNA Gyrase GyrB subunit [3].
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Other names | Coumamycin |
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ECHA InfoCard | 100.164.703 |
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Formula | C55H59N5O20 |
Molar mass | 1110.08 g/mol g·mol−1 |
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See also
Chemically induced dimerization
References
- Heide, L. (2009). "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology Advances. 27 (6): 1006–1014. doi:10.1016/j.biotechadv.2009.05.017. PMID 19463934.
- Heide, L.; Gust, B.; Anderle, C.; Li, S. M. (2008). "Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics". Current Topics in Medicinal Chemistry. 8 (8): 667–679. doi:10.2174/156802608784221505. PMID 18473891.
- Vanden Broeck, A.; McEwen, A.; Chebaro, Y.; Potier, N.; Lamour, V. (2019). "Structural Basis for DNA Gyrase Interaction with Coumermycin A1". Journal of Medicinal Chemistry. 62 (8): 4225–4231. doi:10.1021/acs.jmedchem.8b01928. PMID 30920824.
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