Nitrofuran

Nitrofurans are a class of drugs typically used as antibiotics or antimicrobials.[1] The defining structural component is a furan ring with a nitro group.[2]

Nitrofural (nitrofurazone)

Nifuratel

Members of this class of drugs include:

Antibacterials (antibiotics)
- Difurazone (also known as Nitrovin) — an antibacterial growth promoter used in the animal feeds
- Furazolidone
- Nifurfoline
- Nifuroxazide
- Nifurquinazol
- Nifurtoinol
- Nifurzide
- Nitrofural (also known as nitrofurazone)
- Nitrofurantoin — a drug used to treat urinary tract infections[3]
- Ranbezolid — technically an oxazolidinone antibiotic bearing a nitrofuran group
Antimicrobials
- Furaltadone — an antiprotozoal
- Furazidine — an antibacterial and antiprotozoal
- Furylfuramide — a formerly used food preservative
- Nifuratel — an antiprotozoal and antifungal
- Nifurtimox — an antiprotozoal
FANFT, a potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.

References

Chu, Pak-Sin; Lopez, Mayda I; Abraham, Ann; El Said, Kathleen R; Plakas, Steven M (2008). "Residue Depletion of Nitrofuran Drugs and Their Tissue-Bound Metabolites in Channel Catfish (Ictalurus punctatus) after Oral Dosing". Journal of Agricultural and Food Chemistry. 56 (17): 8030–8034. doi:10.1021/jf801398p. PMID 18698789.
Vass, M; Hruska, K; Franek, M (2008). "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis". Veterinární Medicína. 53: 469–500. doi:10.17221/1979-VETMED.
Huttner, Angela; Verhaegh, Els M; Harbarth, Stephan; Muller, Anouk E; Theuretzbacher, Ursula; Mouton, Johan W (2015). "Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials". Journal of Antimicrobial Chemotherapy. 70 (9): 2456–2464. doi:10.1093/jac/dkv147. PMID 26066581.

External links

Nitrofurans at the US National Library of Medicine Medical Subject Headings (MeSH)

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[1] Chu, Pak-Sin; Lopez, Mayda I; Abraham, Ann; El Said, Kathleen R; Plakas, Steven M (2008). "Residue Depletion of Nitrofuran Drugs and Their Tissue-Bound Metabolites in Channel Catfish (Ictalurus punctatus) after Oral Dosing". Journal of Agricultural and Food Chemistry. 56 (17): 8030–8034. doi:10.1021/jf801398p. PMID 18698789.

[2] Vass, M; Hruska, K; Franek, M (2008). "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis". Veterinární Medicína. 53: 469–500. doi:10.17221/1979-VETMED.

[3] Huttner, Angela; Verhaegh, Els M; Harbarth, Stephan; Muller, Anouk E; Theuretzbacher, Ursula; Mouton, Johan W (2015). "Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials". Journal of Antimicrobial Chemotherapy. 70 (9): 2456–2464. doi:10.1093/jac/dkv147. PMID 26066581.