A chemoreceptor, also known as chemosensor, is a specialized sensory receptor cell which transduces (converts) a chemical substance (endogenous or induced) and generates a biological signal. This signal may be in the form of an action potential if the chemoreceptor is a neuron (nerve cell),[1] or in the form of a neurotransmitter that can activate a nearby nerve fiber if the chemosensor is a specialized sensory receptor cell, such as the taste receptor in a taste bud[2][3] or in an internal peripheral chemoreceptor such as the carotid body (ex, in chemotherapy).[4] In more general terms, a chemosensor detects toxic or hazardous chemicals in the internal or external environment of the human body (e.x. chemotherapy) and transmits that information to the central nervous system, (and rarely the peripheral nervous system), in order to expel the biologically active toxins from the blood, and prevent further consumption of alcohol and/or other acutely toxic recreational intoxicants.

Plant chemoreceptors

Plants have various mechanisms to perceive danger in their environment. Plants are able to detect pathogens and microbes through surface level receptor kinases (PRK). Additionally, receptor-like proteins (RLPs) containing ligand binding receptor domains capture pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPS) which consequently initiates the plant's innate immunity for a defense response.[5]

Plant receptor kinases are also used for growth and hormone induction among other important biochemical processes. These reactions are triggered by a series of signaling pathways which are initiated by plant chemically sensitive receptors.[6] Plant hormone receptors can either be integrated in plant cells or situate outside the cell, in order to facilitate chemical structure and composition. There are 5 major categories of hormones that are unique to plants which once bound to the receptor, will trigger a response in target cells. These include auxin, abscisic acid, gibberellin, cytokinin, and ethylene. Once bound, hormones can induce, inhibit, or maintain function of the target response.[7]


There are two main classes of chemoreceptor: direct and distance.

  • Examples of distance chemoreceptors are:
    • olfactory receptor neurons in the olfactory system: Olfaction involves the ability to detect chemicals in the gaseous state. In vertebrates, the olfactory system detects odors and pheromones in the nasal cavity. Within the olfactory system there are two anatomically distinct organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). It was initially thought that the MOE is responsible for the detection of odorants, while the VNO detects pheromones. The current view, however, is that both systems can detect odorants and pheromones.[8] Olfaction in invertebrates differs from olfaction in vertebrates. For example, in insects, olfactory sensilla are present on their antennae.[9]
  • Examples of direct chemoreceptors include:
    • Taste receptors in the gustatory system: The primary use of gustation as a type of chemoreception is for the detection of tasteants. Aqueous chemical compounds come into contact with chemoreceptors in the mouth, such as taste buds on the tongue, and trigger responses. These chemical compounds can either trigger an appetitive response for nutrients, or a defensive response against toxins depending on which receptors fire. Fish and crustaceans, who are constantly in an aqueous environment, use their gustatory system to identify certain chemicals in the mixture for the purpose of localization and ingestion of food.
    • Insects use contact chemoreception to recognize certain chemicals such as cuticular hydrocarbons and chemicals specific to host plants. Contact chemoreception is more commonly seen in insects but is also involved in the mating behavior of some vertebrates. The contact chemoreceptor is specific to one type of chemical.[9]

Sensory organs

  • Olfaction: In terrestrial vertebrates, olfaction occurs in the nose. Volatile chemical stimuli enter the nose and eventually reach the olfactory epithelium which houses the chemoreceptor cells known as olfactory sensory neurons often referred to as OSNs. Embedded in the olfactory epithelium are three types of cells: supporting cells, basal cells, and OSNs. While all three types of cells are integral to normal function of the epithelium, only OSN serve as receptor cells, i.e. responding to the chemicals and generating an action potential that travels down the olfactory nerve to reach the brain.[1] In insects, antennae act as distance chemoreceptors. For example, antennae on moths are made up of long feathery hairs that increase sensory surface area. Each long hair from the main antenna also has smaller sensilla that are used for volatile olfaction.[10] Since moths are mainly nocturnal animals, the development of greater olfaction aids them in navigating the night.
  • Gustation: In many terrestrial vertebrates, the tongue serves as the primary gustatory sensory organ. As a muscle located in the mouth, it acts to manipulate and discern the composition of food in the initial stages of digestion. The tongue is rich in vasculature, allowing the chemoreceptors located on the top surface of the organ to transmit sensory information to the brain. Salivary glands in the mouth allow for molecules to reach chemoreceptors in an aqueous solution. The chemoreceptors of the tongue fall into two distinct superfamilies of G protein-coupled receptors. GPCR's are intramembrane proteins than bind to an extracellular ligand- in this case chemicals from food- and begin a diverse array of signaling cascades that can result in an action potential registering as input in an organism's brain. Large quantities of chemoreceptors with discrete ligand-binding domains provide for the five basic tastes: sour, salty, bitter, sweet, and savory. The salty and sour tastes work directly through the ion channels, the sweet and bitter taste work through G protein-coupled receptors, and the savory sensation is activated by glutamate.Gustatory chemosensors are not just present on the tongue but also on different cells of the gut epithelium where they communicates the sensory information to several effector systems involved in the regulation of appetite, immune responses, and gastrointestinal motility.[11]
  • Contact Chemoreception: Contact chemoreception is dependent on the physical contact of the receptor with the stimulus. The receptors are short hairs or cones that have a single pore at, or close to the tip of the projection. They are known as uniporous receptors. Some receptors are flexible, while others are rigid and do not bend with contact. They are mostly found in the mouthparts, but can also occur on the antennae or legs of some insects. There is a collection of dendrites located near the pores of the receptors, yet the distribution of these dendrites changes depending on the organism being examined. The method of transduction of the signal from the dendrites differs depending on the organism and the chemical it is responding to.
  • Cellular antennae: Within the biological and medical disciplines, recent discoveries have noted that primary cilia in many types of cells within eukaryotes serve as cellular antennae. These cilia play important roles in chemosensation. The current scientific understanding of primary cilia organelles views them as "sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation."[12]

When inputs from the environment are significant to the survival of the organism, the input must be detected. As all life processes are ultimately based on chemistry it is natural that detection and passing on of the external input will involve chemical events. The chemistry of the environment is, of course, relevant to survival, and detection of chemical input from the outside may well articulate directly with cell chemicals.

Chemoreception is important for the detection of food, habitat, conspecifics including mates, and predators. For example, the emissions of a predator's food source, such as odors or pheromones, may be in the air or on a surface where the food source has been. Cells in the head, usually the air passages or mouth, have chemical receptors on their surface that change when in contact with the emissions. It passes in either chemical or electrochemical form to the central processor, the brain or spinal cord. The resulting output from the CNS (central nervous system) makes body actions that will engage the food and enhance survival.


Control of breathing

Particular chemoreceptors, called ASICs, detect the levels of carbon dioxide in the blood. To do this, they monitor the concentration of hydrogen ions in the blood, which decrease the pH of the blood. This can be a direct consequence of an increase in carbon dioxide concentration, because aqueous carbon dioxide in the presence of carbonic anhydrase reacts to form a proton and a bicarbonate ion.

The response is that the respiratory centre (in the medulla), sends nervous impulses to the external intercostal muscles and the diaphragm, via the intercostal nerve and the phrenic nerve, respectively, to increase breathing rate and the volume of the lungs during inhalation.

Chemoreceptors that regulate the depth and rhythm of breathing are broken down into two categories.

  • central chemoreceptors are located on the ventrolateral surface of medulla oblongata and detect changes in pH of cerebrospinal fluid. They have also been shown experimentally to respond to hypercapnic hypoxia (elevated CO
    , decreased O2), and eventually desensitize . These are sensitive to pH and CO
  • peripheral chemoreceptors: consists of aortic and carotid bodies. Aortic body detects changes in blood oxygen and carbon dioxide, but not pH, while carotid body detects all three. They do not desensitize. Their effect on breathing rate is less than that of the central chemoreceptors.

Heart rate

The response to stimulation of chemoreceptors on the heart rate is complicated. Chemoreceptors in the heart or nearby large arteries as well as chemoreceptors in the lungs can affect heart rate. Activation of these peripheral chemoreceptors from sensing decreased O2, increased CO2 and a decreased pH is relayed to cardiac centers by the vagus and glossopharyngeal nerves to the medulla of the brainstem. This increases the sympathetic nervous stimulation on the heart and a corresponding increase in heart rate and contractility in most cases.[13] These factors include activation of stretch receptors due to increased ventilation and the release of circulating catecholamines.

However, if respiratory activity is arrested (e.g. in a patient with a high cervical spinal cord injury), then the primary cardiac reflex to transient hypercapnia and hypoxia is a profound bradycardia and coronary vasodilation through vagal stimulation and systemic vasoconstriction by sympathetic stimulation.[14] In normal cases, if there is reflexive increase in respiratory activity in response to chemoreceptor activation, the increased sympathetic activity on the cardiovascular system would act to increase heart rate and contractility.

See also


  1. Rawson, Nancy E.; Yee, Karen K. (2006). "Transduction and Coding". Taste and Smell. Advances in Oto-Rhino-Laryngology. 63. pp. 23–43. doi:10.1159/000093749. ISBN 3-8055-8123-8. PMID 16733331.
  2. Saunders, CJ; Christensen, M; Finger, TE; Tizzano, M (2014). "Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation". Proceedings of the National Academy of Sciences. 111 (16): 6075–80. Bibcode:2014PNAS..111.6075S. doi:10.1073/pnas.1402251111. PMC 4000837. PMID 24711432.
  3. Finger, Thomas E.; Kinnamon, Sue C. (2013-01-01). "A taste for ATP: neurotransmission in taste buds". Frontiers in Cellular Neuroscience. 7: 264. doi:10.3389/fncel.2013.00264. PMC 3866518. PMID 24385952.
  4. Nurse, Colin A. (2013). "Signal processing at mammalian carotid body chemoreceptors". Semin Cell Dev Biol. 24 (1): 22–30. doi:10.1016/j.semcdb.2012.09.006. PMID 23022231.
  5. Zipfel, Cyril (July 2014). "Plant pattern-recognition receptors". Trends in Immunology. 35 (7): 345–351. doi:10.1016/ PMID 24946686.
  6. Haffani, Yosr Z; Silva, Nancy F; Goring, Daphne R (1 January 2004). "Receptor kinase signalling in plants". Canadian Journal of Botany. 82 (1): 1–15. doi:10.1139/b03-126.
  7. Lynne, Armitage; Ottoline, Leyser (2014). "Plant hormone receptors". Access Science. doi:10.1036/1097-8542.900137.
  8. Shi, P.; Zhang, J. (2009). "Extraordinary Diversity of Chemosensory Receptor Gene Repertoires Among Vertebrates". Chemosensory Systems in Mammals, Fishes, and Insects. Results and Problems in Cell Differentiation. 47. pp. 57–75. doi:10.1007/400_2008_4. ISBN 978-3-540-69918-7. PMID 19145414.
  9. Chapman RF (1998) "Chemoreception" in The Insects: structure and function 4th edition. Cambridge University Press, Cambridge. 639.
  10. Haupt, S. Shuichi; Sakurai, Takeshi; Namiki, Shigehiro; Kazawa, Tomoki; Kanzaki, Ryohei (2010). "Olfactory information processing in moths". The Neurobiology of Olfaction. CRC Press/Taylor & Francis. ISBN 9781420071979.
  11. Steensels, S; Depoortere, I (2018). "Chemoreceptors in the Gut". Annu Rev Physiol. 80: 117–141. doi:10.1146/annurev-physiol-021317-121332. PMID 29029594.
  12. Satir, Peter; Christensen, Søren T. (2008). "Structure and function of mammalian cilia". Histochemistry and Cell Biology. 129 (6): 687–93. doi:10.1007/s00418-008-0416-9. PMC 2386530. PMID 18365235.
  13. "Chapter 4". Retrieved 2017-01-29.
  14. Berk, J. L.; Levy, M. N. (1977-01-01). "Profound reflex bradycardia produced by transient hypoxia or hypercapnia in man". European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes. 9 (2): 75–84. doi:10.1159/000127928. ISSN 0014-312X. PMID 852474.
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