CFU-GM (or "GMP", for "granulocyte-macrophage progenitor") is a colony forming unit. It is derived from CFU-GEMM.
Lineage. Captions in Polish, but "GMP" visible near bottom center.
|Gives rise to||Monoblasts and myeloblasts|
|Function||colony forming unit|
|Anatomical terms of microanatomy|
The "GM" stands for "granulocyte, monocyte".
It is the precursor for monoblasts and myeloblasts.
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
There is some controversy over which granulocytes derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".
- "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
- Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
- Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.
- CFU-GM at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.