A promegakaryocyte is a precursor cell for a megakaryocyte, arising from a megakaryoblast.


The developmental stages of the megakaryocyte are: CFU-Me (pluripotential hemopoietic stem cell or hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte.

When the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication[1] and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm.[2] The promegakaryocyte has rotary motion, but no forward migration.[3]


  1. Khurana, Indu (November 20, 2009). Textbook of Human Physiology for Dental Students. Elsevier India. p. 141. ISBN 8131205924.
  2. Rozenberg, Gillian (December 19, 2002). Microscopic Haematology: A Practical Guide for the Laboratory (2nd ed.). CRC Press. p. 95. ISBN 1841842338.
  3. Hiraki, K.; Ofuji, T.; Kobayashi, T.; Sunami, H.; Awai, K. (January 31, 1956). "On the function of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombocytopenic Purpura and in Normal Adult". Acta Medicinae Okayama. 10 (2): 57–61. Retrieved July 21, 2017.

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