The developmental stages of the megakaryocyte are: CFU-Me (pluripotential hemopoietic stem cell or hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte.
When the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm. The promegakaryocyte has rotary motion, but no forward migration.
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- Rozenberg, Gillian (December 19, 2002). Microscopic Haematology: A Practical Guide for the Laboratory (2nd ed.). CRC Press. p. 95. ISBN 1841842338.
- Hiraki, K.; Ofuji, T.; Kobayashi, T.; Sunami, H.; Awai, K. (January 31, 1956). "On the function of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombocytopenic Purpura and in Normal Adult". Acta Medicinae Okayama. 10 (2): 57–61. Retrieved July 21, 2017.
- "Marrow aspirate, 10x. Promegakaryocyte" at ttuhsc.edu
- "Megakaryocytes: Promegakaryocyte" at bloodline.net