Granulopoiesis (or granulocytopoiesis) is production of granulocytes. A granulocyte is a type of white blood cell that has multilobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell.[1] This hematopoiesis occurs primarily within bone marrow. Note that granulopoeisis does not generally include in the definition the generation of mast cells, since although they are granulocytes too, their maturation is extramedullar[2].

The four key transcription factors involved in this process are C/EBPα, PU.1, CBF, and c-Myb.[3]

The following stages are involved:

This process can be stimulated by Candida albicans.[4]


  1. Monie, Tom (January 2017). The Innate Immune System: A compositional and functional perspective. Christ’s College and Institute of Continuing Education, University of Cambridge, United Kingdom. doi:10.1016/B978-0-12-804464-3.01001-2. ISBN 9780128044643.
  2. Mahler, edited by Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, associate editor, Brad Bolon, Ricardo Ochoa, illustrations editor, Beth W. (2013). Haschek and Rousseaux's handbook of toxicologic pathology (Third ed.). [S.l.]: Academic Press. p. 1863. ISBN 978-0-12-415759-0.CS1 maint: extra text: authors list (link)
  3. Ward, AC; Loeb, DM; Soede-Bobok, AA; Touw, IP; Friedman, AD (2000). "Regulation of granulopoiesis by transcription factors and cytokine signals". Leukemia. 14 (6): 973–990. doi:10.1038/sj.leu.2401808.
  4. Basu S, Zhang HH, Quilici C, Dunn AR (February 2004). "Candida albicans can stimulate stromal cells resulting in enhanced granulopoiesis". Stem Cells Dev. 13 (1): 39–50. doi:10.1089/154732804773099245. PMID 15068692.

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