Advanced cardiac life support

The 2015 ACLS guidelines promoted minor tweaks and improvements to the 2010 guidelines with no major changes. Some changes included:

• In conjunction with the BLS guidelines, the update promoted the use of mobile phones to activate the Emergency Response System as well as notify nearby rescuers.[4]
• It was recommended that emergency medical dispatchers receive better guidance on recognizing potential Cardiac Arrests and agonal breathing to promote more immediate CPR instructions.[4]
• Lay persons are further encouraged to perform continuous hands-only CPR at a minimum until EMS arrival.[4]
• An upper boundary for the number of chest compressions was added at 120 per minute, making the current recommendation 100-120 per minute. The 2010 guidelines only stated 100+ per minute.[4]
• An upper boundary on the depth of chest compressions was added at 2.4 inches, making the current recommendation 2-2.4 inches. The 2010 guidelines only stated at least 2 inches.[4]
• Added BLS and lay person administration of naloxone (IM or IN) for suspected opiate overdoses.[4]
• For simplicity, vasopressin was removed from the Cardiac Arrest Algorithm.[4]
• Waveform capnography was further emphasized and an ETCO₂ of less than 10 mmHg after 20 minutes of resuscitation was added as legitimate factor in the decision to terminate resuscitation.[4]
• Targeted temperature management was further refined with a new goal range 32-36 °C.[5]
• Routine atropine use in intubations is no longer recommended unless there is a high risk for bradycardia.[5]
• The OHCA and IHCA (Out of hospital cardiac arrest) and (In Hospital Cardiac arrest) Chain also has been added as different ones. Separate Chains of Survival have been recommended that identify the different pathways of care for patients who experience cardiac arrest in the hospital as distinct from out-of-hospital settings.[4]

The ACLS guidelines were updated by the American Heart Association[6] and the International Liaison Committee on Resuscitation[7] in 2010. New ACLS guidelines focus on BLS as the core component of ACLS.[2] Foci also include end tidal CO
₂ monitoring as a measure of CPR effectiveness, and as a measure of ROSC. Other changes include the exclusion of atropine administration for pulseless electrical activity (PEA) and asystole. CPR (for ACLS and BLS) was reordered from "ABC" to "CAB" (circulation, airway, breathing) to bring focus to chest compressions, even recommending compression-only CPR for laypersons. (note, however, that in pediatric resuscitation, respiratory arrest is more likely to be the main cause of arrest than adults.[8])

The 2005 guidelines acknowledged that high quality chest compressions and early defibrillation are the key to positive outcomes, while other "typical ACLS therapies ... "have not been shown to increase rate of survival to hospital discharge".[9] In 2004, a study found that the basic interventions of CPR and early defibrillation and not the advanced support improved survival from cardiac arrest.[10]

The 2005 guidelines were published in Circulation.[11] The major source for ACLS courses and textbooks in the United States is the American Heart Association; in Europe, it is the European Resuscitation Council (ERC). Most institutions expect their staff to recertify at least every two years. Many sites offer training in simulation labs with simulated code situations with a dummy. Other hospitals accept software-based courses for recertification. An ACLS Provider Manual reflecting the new Guidelines is now available.

Stroke is also included in the ACLS course with emphasis on the stroke chain of survival.[12]

AEDs were first recommended by the AHA for determining if ventricular fibrillation was occurring in 1995. The most notable change to the A-B-C algorithm in 1995 included adding a “D”to Defibrillate with an AED.[13]

Cardiac Arrest Algorithm
Acute Coronary Syndromes Algorithm
Pulseless Electrical Activity (PEA)/Asystole Algorithm
Ventricular Fibrillation (VF)/Pulseless Ventricular Tachycardia (VT) Algorithm
Bradycardia Algorithm
Tachycardia Algorithms
Respiratory Arrest Algorithm
Opioid Emergency Algorithm
Post-Cardiac Arrest Algorithm
Suspected Stroke Algorithm

• Search for and correct potentially reversible causes of arrest, brady/tachycardia.The reversible causes of cardiac arrests are colloquially referred to as the 5 Hs and Ts. The H’s stand for the following: Hypovolemia; Hypoxia/Hypoxemia; Hydrogen Ion Excess (Acidosis); Hypokalemia/Hyperkalemia; and Hypothermia while the T’s represent: Tamponade (Cardiac); Toxins; Tension Pneumothorax; and Thrombosis (Coronary or Pulmonary).
• Exercise caution before using epinephrine in arrests associated with cocaine or other sympathomimetic drugs. Epinephrine is not required until after the second DC shock in standard ACLS management as DC shock in itself releases significant quantities of epinephrine[14]
• Administration of atropine 1 mg dose (IV) bolus for asystole or slow PEA (rate<60/min) is no longer recommended.[15]
• In PEA arrests associated with hyperkalemia, hypocalcemia, or Ca²⁺
  channel blocking drug overdose, give 10mL 10% calcium chloride (IV) (6.8 mmol/L)
• Consider amiodarone for ventricular fibrillation/pulseless ventricular tachycardia after 3 attempts at defibrillation, as there is evidence it improves response in refractory VF / VT.(Note: as of the 2010 guidelines, amiodarone is preferred as the first-line antiarrythmic, moving lidocaine to a second-line backup if amiodarone is unavailable[16]
• For torsades de pointes, refractory VF in people with digoxin toxicity or hypomagnesemia, give IV magnesium sulfate 8 mmol (4mL of 50% solution)
• In the 2010 ACLS pulseless arrest algorithm, vasopressin may replace the first or second dose of epinephrine.[17]