ABCs Report: Neisseria meningitidis, 2001

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Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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ABCs Areas

California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia; Maryland; Minnesota; New York (15 county Rochester/Albany area); Oregon; Tennessee (11 county area).

ABCs Population

The surveillance areas represent 36,033,178 persons. Source: National Center for Health Statistics bridged-race
vintage 2001 postcensal file

ABCs Case Definition

Invasive meningococcal disease: isolation of Neisseria meningitidis from normally sterile site in a resident of a surveillance area in 2001.

ABCs Methodology

Project personnel communicated at least monthly with contacts in all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Molecular subtyping was done on meningococcal isolates at CDC. Regular laboratory audits assess completeness of active surveillance and detect additional cases.

All rates of invasive meningococcal disease were calculated using population estimates for 2001.

For national projections of cases, race- and age-specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2001 U.S. population.

Cases with unknown race were distributed by area based on reported race distribution for known cases within the eight age categories.

Reported ABCs Profiles

Race	No.	(Rate^*)
White	213	(0.8)
Black	68	(1.1)
Other	8	(0.4)
Total	289	(0.8)

Unknown race (n=45) distributed amongst knowns

^* Cases per 100,000 population for ABCs areas

Syndrome	Cases No. (%^*)	Deaths No. (Rate^†)
Meningitis	138 (47.8)	11 (8.0)
Bacteremia without focus	114 (39.4)	16 (14.3)

^*Percent of cases

^†Deaths per 100 cases with known outcome

Age (years)	B No. (Rate^*)	Serogroups C No. (Rate^*)	Serogroups Y No. (Rate^*)	Other No. (Rate^*)
<1	22 (4.3)	3 (0.6)	6 (1.2)	3 (0.6)
1	8 (1.6)	2 (0.4)	0 (0.0)	2 (0.4)
2-4	12 (0.8)	6 (0.4)	3 (0.2)	5 (0.3)
5-17	13 (0.2)	15 (0.2)	9 (0.1)	7 (0.1)
18-34	26 (0.3)	16 (0.2)	9 (0.1)	12 (0.1)
35-49	13 (0.1)	7 (0.1)	13 (0.1)	7 (0.1)
50-64	4 (0.1)	9 (0.2)	11 (0.2)	5 (0.1)
≥ 65	6 (0.1)	9 (0.2)	21 (0.5)	5 (0.1)
Total	104 (0.3)**	67 (0.2)	72 (0.2)	46 (0.1)

^*Cases per 100,000 population for ABCs areas

^** The rate of serogroup B disease excluding Oregon is 0.2 cases per 100,000 population for ABCs areas.

Rates of Meningococcal Disease in Adolescents and Young Adults

Age (years)	Overall Serogroups No. (Rate*)	C/Y/W-135 Serogroups No. (Rate*)
14-17	20 (0.99)	14 (0.69)
18-22	36 (1.46)	14 (0.57)

^*Cases per 100,000 population for ABCs areas

National Estimates of Invasive Disease

Cases: 1,975 (0.7/100,000)
Deaths: 200 (0.1/100,000)

Healthy People 2010 Update

Objective: Reduce the incidence of invasive meningococcal disease to 0.9 per 100,000 population.

2010 Objective	2001 Rate^*
0.9/100,000	0.7/100,000

^*Cases per 100,000 U.S. population

Source:

ABCs/National Electronic Telecommunications System for Surveillance (NETSS)

Citation

Centers for Disease Control and Prevention. 2002. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Neisseria meningitidis, 2001.

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