ABCs Report: Haemophilus influenzae, 2012

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Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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^¶Surveillance Note

Missing race (n=78) data-were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia; Maryland; Minnesota; New Mexico; New York (15 county Rochester and Albany areas); Oregon; Tennessee (20 urban counties)

ABCs Population

The surveillance areas represent 42,803,061 persons.

Source: National Center for Health Statistics bridged‑race vintage 2012 postcensal file

ABCs Case Definition

Invasive Haemophilus influenzae (Hi) disease: isolation of Hi from normally sterile site in a resident of a surveillance area in 2012.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Serotyping was done on Hi isolates at CDC and state laboratories. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

All rates of invasive Hi disease were calculated using population estimates for 2012. For national estimates, race‑ and age‑specific rates of disease were applied from the aggregate surveillance areas to the race‑ and age‑specific distribution of the 2012 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using the sequential regression imputation method.^¶

Reported ABCs Profiles

Race	No.	(Rate^*)
White	537	(1.7)
Black	126	(1.7)
Other	43	(1.3)
Total	706	(1.7)

^* Cases per 100,000 population for ABCs areas

Syndrome	Cases No. (Rate^*)	Deaths No. (Rate^†)
Meningitis	39 (5.5)	0 (0.0)
Bacteremia without focus	173 (24.5)	26 (15.0)

^* Percent of cases
^† Deaths per 100 cases with known outcome

Age (years)	Serotype b No. (Rate^*)	Serotype Non‑b No. (Rate^*)	Serotype Non‑Type^† No. (Rate^*)	Serotype Unknown No. (Rate^*)
< 1	2 (0.38)	11 (2.08)	27 (5.10)	2 (0.38)
1	0 (0.00)	10 (1.87)	6 (1.12)	0 (0.00)
2‑4	3 (0.18)	7 (0.43)	9 (0.55)	3 (0.18)
5‑17	1 (0.01)	3 (0.04)	14 (0.19)	2 (0.03)
18‑34	0 (0.00)	3 (0.03)	39 (0.39)	5 (0.05)
35‑49	0 (0.00)	18 (0.21)	32 (0.37)	5 (0.06)
50‑64	3 (0.04)	52 (0.62)	91 (1.08)	17 (0.20)
≥ 65	1 (0.02)	75 (1.34)	220 (3.94)	42 (0.75)
Total	10 (0.02)	179 (0.42)	438 (1.02)	76 (0.18)

^* Cases per 100,000 population for ABCs areas
^† Non‑typeable isolates

National Estimates for Invasive Disease

Cases: 5,200 (1.66/100,000)
Deaths: 700 (0.22/100,000)

Healthy People 2020 Update

Invasive Haemophilus influenzae type b disease

Objective: Decrease the incidence of invasive Haemophilus influenzae type b disease to 0.27 cases per 100,000 persons less than 5 years of age.

Age (year)	2020 Objective	2012 Rate^*
< 5	0.27/100,000	0.20/100,000

^* Cases per 100,000 U.S. population < 5 years

Citation

Centers for Disease Control and Prevention. 2012. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Haemophilus influenza 2012.

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