Substances |
PDN Description |
Status (1) |
Aldrin/Dieldrin
|
- Dose-response data in animals for intermediate(2)-duration oral exposure
- Bioavailability from soil
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Arsenic
|
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
- Bioavailability from soil
|
Filled |
Asbestos |
- Potential candidate for subregistry of exposed persons
- Improved analytical methods for screening samples and determining the chemical structure of asbestos fibers. Also, techniques to normalize studies in which different analytical methods were employed
|
Filled |
Benzene |
- Epidemiologic studies on the health effects of benzene (special emphasis end points include immunotoxicity)
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Beryllium |
- Analytical methods to determine environmental speciation
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Cadmium |
- Analytical methods for biological tissues and fluids and environmental media
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Carbon tetrachloride |
- Immunotoxicology battery of tests via oral exposure
- Half-life in soil
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Chlordane
|
- Oral multigenerational studies to evaluate reproductive toxicity
- Exposure levels in humans (adults) living near hazardous waste sites and other populations potentially exposed to chlordane
- Exposure levels in children
|
Filled |
Chlorinated dibenzo-p-dioxins (CDDs) |
- Studies via oral exposure designed to assess childhood susceptibility
- Exposure levels in humans (adults) living near hazardous waste sites
- Exposure levels in children
|
Filled |
Chloroform |
- Dose-response data in animals for intermediate-duration oral exposure
- Epidemiologic studies on the health effects of chloroform (Special emphasis end points include cancer, neurotoxicity, reproductive and developmental toxicity, hepatotoxicity, and renal toxicity)
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Chromium
|
- Dose-response data in animals for acute(3)-duration exposure to chromium (VI) via oral exposure
- Dose-response data in animals for intermediate-duration exposure to chromium (VI) via oral exposure
- Multigeneration reproductive toxicity study via oral exposure to chromium (VI)
- Prenatal developmental toxicity study via oral exposure to chromium (VI)
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Cyanide
|
- Evaluation of the environmental fate of cyanide in soil
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
1,2-dibromo-3-chloropropane |
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
1,2-Dibromoethane |
- Immunotoxicity battery studies via oral exposure
- Dose-response data in animals for acute-duration exposure by the oral route
|
Filled |
1,2-Dichloroethane |
- Neurotoxicology battery of tests following inhalation exposure
- Exposure levels in humans living near hazardous waste sites and other populations
|
Filled |
1,1-Dichloroethene |
- Dose-response data in animals for acute-duration exposure by the inhalation route
- Dose-response data in animals for chronic(4)-duration exposure by the inhalation route
- Dose-response data in animals for acute-duration exposure by the oral route
- Dose-response data in animals for intermediate-duration exposure by the oral route
- Prenatal developmental toxicity studies following oral exposure
- Exposure levels in humans living near hazardous waste sites and other populations
|
Filled |
DDT |
- Epidemiologic studies on the health effects of DDT, DDD, and DDE (Special emphasis end points include immunotoxicity, and reproductive and developmental toxicity)
- Bioavailability and bioaccumulation from soil
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Di(2-ethylhexyl) phthalate
|
- Epidemiologic studies on the health effects of DEHP
- Dose-response data in animals for acute-duration oral exposure
- Dose-response data in animals for intermediate-duration oral exposure
- Multigeneration reproductive toxicity study via oral exposure
- Comparative toxicokinetic studies (Studies designed to examine how primates metabolize and distribute DEHP as compared with rodents via oral exposure)
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Di-n-butyl phthalate |
- Dose-response data in animals for acute- duration exposure via the oral route
- In vivo genotoxicity studies
- Environmental fate of di-n-butyl phthalate in environmental media
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Disulfoton
|
- Immunotoxicology testing battery following oral exposure
|
Filled |
Endosulfan (α,β, and sulfate) |
- Data on the bioavailability of endosulfan from soil
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Endrin/endrin aldehyde |
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Ethylbenzene |
- Dose-response data for acute-duration exposure by the inhalation route
- Dose-response data for chronic-duration exposure by the inhalation route
- Dose-response data for intermediate-duration exposure by the oral route
- Multigeneration toxicity study examining reproductive end points and indicators of endocrine disruption following inhalation exposure
- Studies for comparative toxicokinetics
- Exposure levels in humans living near hazardous waste sites
- Exposure levels in children
|
Filled
|
Heptachlor/
heptachlor epoxide
|
- Multigeneration reproductive toxicity studies via the oral route of exposure
- Prenatal developmental toxicity studies via the oral route of exposure
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
- Dose-response animal data for acute- and intermediate-duration oral exposures, including immunopathology
- Bioavailability from contaminated air, water, and soil and bioaccumulation potential
|
Filled |
Hexachloro-cyclohexane (α, β, γ, and δ) |
- Dose-response data for chronic-duration oral exposure
- Mechanistic studies on the neurotoxicity of hexachlorocyclohexane
- Mechanistic studies on the hepatotoxicity of hexachlorocyclohexane
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Lead |
- Mechanistic studies on the neurotoxic effects of lead
- Analytical methods for tissue levels
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Manganese |
- Dose-response data for acute- and intermediate-duration oral exposures
- Toxicokinetic studies on animals to investigate uptake and absorption, relative uptake of differing manganese compounds, metabolism of manganese, and interaction of manganese with other substances following oral exposure
- Epidemiological studies on the health effects of manganese (special emphasis end points include neurologic, reproductive, developmental, immunologic, and cancer)
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Mercury |
- Multigeneration reproductive toxicity study via oral exposure
- Dose-response data in animals for chronic-duration oral exposure
- Immunotoxicology studies via oral exposure
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Methoxychlor
|
- Evaluate neurologic effects after long-term, low-level oral exposure
- Exposure levels in humans (adults) living near hazardous waste sites and other populations
- Exposure levels in children
|
Filled |
Methylene chloride |
- Dose-response data in animals for acute- and intermediate-duration oral exposure. The intermediate-duration study should include extended reproductive organ histopathology, neuropathology, and immunopathology
- Prenatal developmental toxicity study via the oral route
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled(5) |
Nickel |
- Epidemiologic studies on the health effects of nickel (Special emphasis end points include reproductive toxicity)
- Prenatal developmental toxicity study via the oral route
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Pentachlorophenol |
- Exposure levels in humans (adults) living near hazardous waste sites
- Exposure levels in children through play activities near contaminated environmental media
|
Filled |
Polychlorinated biphenyls (PCBs) |
- Epidemiologic studies on the health effects of PCBs (special emphasis end points include immunotoxicity, gastrointestinal toxicity, liver toxicity, kidney toxicity, thyroid toxicity, and reproductive/developmental toxicity)
- Dose-response data in animals for acute-duration oral exposures
- Dose-response data in animals for intermediate-duration oral exposures
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
- Chronic toxicity and oncogenicity via oral exposure(6)
- Aerobic PCB biodegradation in sediment(6)
- PCB congener analysis(6)
|
Filled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
|
- Dose-response data in animals for intermediate-duration oral exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology
- Prenatal developmental toxicity study via inhalation or oral exposure
- Mechanistic studies on PAHs, on how mixtures of PAHs can influence the ultimate activation of PAHs, and on how PAHs affect rapidly proliferating tissues
- Dose-response data in animals for acute- and intermediate-duration inhalation exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology
- Epidemiologic studies on the health effects of PAHs (Special emphasis end points include cancer, dermal, hemolymphatic,and hepatic toxicity)
- Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Selenium |
- Epidemiologic studies on the health effects of selenium (special emphasis end points include cancer, reproductive and developmental toxicity, hepatotoxicity, and adverse skin effects)
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
1,1,2,2-Tetrachloroethane |
- Exposure levels in humans living near hazardous waste sites and other populations
|
Filled |
Tetrachloroethylene |
- Dose-response data in animals for acute-duration oral exposure, including neuropathology and demeanor, and immunopathology
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Toluene |
- Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immune system
- Comparative toxicokinetic studies (characterization of absorption, distribution, and excretion via oral exposure)
- Mechanism of toluene-induced neurotoxicity
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Toxaphene |
- Immunotoxicity studies for chronic-duration via oral route of exposure
|
Filled |
Trichloroethylene |
- Dose-response data in animals for acute-duration oral exposure
- Epidemiologic studies on the health effects of trichloroethylene (special emphasis end points include cancer, hepatotoxicity, renal toxicity, developmental toxicity, and neurotoxicity)
- Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers
|
Filled |
Vinyl chloride |
- Dose-response data in animals for acute-duration inhalation exposure
- Multigeneration reproductive toxicity study via inhalation
- Prenatal developmental toxicity study via inhalation
|
Filled |
Xylenes |
- Dose-response data for chronic-duration exposure by the oral route. This study should be done in conjunction with the neurotoxicology battery of tests
- Prenatal developmental toxicity study that includes neurodevelopmental end points following oral exposure
- Exposure levels in humans living near hazardous waste sites and other populations
|
Filled
|
Zinc |
- Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immunologic and neurologic systems
- Multigeneration reproductive toxicity study via oral exposure
|
Filled |