UMB66

UMB66
Identifiers
	IUPAC name 3-chloropropionic acid;
CAS Number	107-94-8 ;
PubChem CID	7899;
ChemSpider	7611;
UNII	R5J180FN9Z;
CompTox Dashboard (EPA)	DTXSID5021546 ;
ECHA InfoCard	100.003.214
Chemical and physical data
Formula	C3H5ClO2
Molar mass	108.52 g/mol g·mol−1
3D model (JSmol)	Interactive image;
Melting point	42 °C (108 °F)
Boiling point	204 °C (399 °F) (decomp.)
	SMILES C(CCl)C(=O)O;
	InChI InChI=1S/C3H5ClO2/c4-2-1-3(5)6/h1-2H2,(H,5,6); Key:QEYMMOKECZBKAC-UHFFFAOYSA-N;
(verify)

3-Chloropropanoic acid (also 3-chloropropionic acid) or UMB66 is a drug used in scientific research. It is structurally related to GHB and binds to the GHB receptor, but has no affinity for GABA receptors.[1] It is also an active ingredient in some herbicide blends.[2] Overdose may cause unconsciousness and/or convulsions.[3]

References

Macias, A. T.; Hernandez, R. J.; Mehta, A. K.; MacKerell, A. D. Jr; Ticku, M. K.; Coop, A. (2004). "3-Chloropropanoic acid (UMB66): A ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group". Bioorganic & Medicinal Chemistry. 12 (7): 1643–1647. doi:10.1016/j.bmc.2004.01.025. PMID 15028257.
Ng, H. J.; Ab. Wahab, R.; Cooper, R. A.; Huyop, F. (2005). "Degradation Of Herbicide (3-Chloropropionic Acid) By Bacterial Dehalogenases" (PDF). Proc. KUSTEM 4th Annual Seminar 2005: 586–590. Archived from the original (pdf) on 2016-03-05.
"Chemical Data Sheet for 3-CHLOROPROPIONIC ACID". NOAA.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Macias, A. T.; Hernandez, R. J.; Mehta, A. K.; MacKerell, A. D. Jr; Ticku, M. K.; Coop, A. (2004). "3-Chloropropanoic acid (UMB66): A ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group". Bioorganic & Medicinal Chemistry. 12 (7): 1643–1647. doi:10.1016/j.bmc.2004.01.025. PMID 15028257.

[2] Ng, H. J.; Ab. Wahab, R.; Cooper, R. A.; Huyop, F. (2005). "Degradation Of Herbicide (3-Chloropropionic Acid) By Bacterial Dehalogenases" (PDF). Proc. KUSTEM 4th Annual Seminar 2005: 586–590. Archived from the original (pdf) on 2016-03-05.

[3] "Chemical Data Sheet for 3-CHLOROPROPIONIC ACID". NOAA.