Pustulosis palmaris et plantaris

Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils.[2]:411,628[3]:204 It can occur as part of the SAPHO syndrome.[4]

Pustulosis palmaris et plantaris
Other namesPustulosis of palms and soles,[1] Palmoplantar pustulosis, Persistent palmoplantar pustulosis, Pustular psoriasis of the Barber type, and Pustular psoriasis of the extremities
Pustulosis palmaris et plantaris
SpecialtyDermatology 
Differential diagnosisSAPHO syndrome

Diagnosis

Treatment

Several treatments are used to improve the symptoms of palmoplantar pustulosis. Oral acitretin is found to be effective especially in combination with psoralens and ultraviolet radiation (PUVA) treatment. Other treatments include oral ciclosporin and tetracycline antibiotics.[5]Treatment with guselkumab, an anti–interleukin 23 monoclonal antibody has shown a decrease in the size of the area effected and severity.[6]

See also

References

  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  4. Matzaroglou, Ch; Velissaris, D; Karageorgos, A; Marangos, M; Panagiotopoulos, E; Karanikolas, M (5 November 2009). "SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature". The Open Orthopaedics Journal. 3: 100–6. doi:10.2174/1874325000903010100. PMC 2790148. PMID 19997538.
  5. Chalmers, Robert; Hollis, Sally; Leonardi-Bee, Jo; Griffiths, Christopher EM; Marsland Bsc MRCP, Alexander (2006-01-25). "Interventions for chronic palmoplantar pustulosis". Cochrane Database of Systematic Reviews (1): CD001433. doi:10.1002/14651858.CD001433.pub2. ISSN 1465-1858. PMID 16437433.
  6. Terui, Tadashi; Kobayashi, Satomi; Okubo, Yukari; Murakami, Masamoto; Zheng, Richuan; Morishima, Hitomi; Goto, Ryosuke; Kimura, Takayuki (1 October 2019). "Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis". JAMA Dermatology. 155 (10): 1153. doi:10.1001/jamadermatol.2019.1394. PMC 6613288. PMID 31268476.
Classification


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