Monocytopenia

Monocytopenia
Specialty	Hematology

Monocytopenia is a form of leukopenia associated with a deficiency of monocytes. The causes of monocytopenia include: acute infections, stress, treatment with glucocorticoids, aplastic anemia, hairy cell leukemia, acute myeloid leukemia, treatment with myelotoxic drugs and genetic syndromes, as for example MonoMAC syndrome.[1]

It has been proposed as a measure to predict neutropenia,[2] though some research indicates that it is less effective than lymphopenia.[3]

Causes

Some of the causes are:

- acute infections

- stress

- treatment with glucocorticoids

- aplastic anemia

- hairy cell leukemia

- acute myeloid leukemia

- treatment with myelotoxic drugs

- genetic syndromes (eg.: MonoMAC syndrome)

Diagnosis

- Blood Test (CBC) (Normal range of Monocytes: 1-10%) (Normal range in males: 0.2-0.8 x 10 3 /microliter)

- Blood test checking for monocypenia (Abnormal ranges: <1%) (Abnormal range in males: <0.2 10 3 /microliter)

Treatment

References

Harrison's principles of internal medicine. New York: McGraw-Hill. 2005. p. 356. ISBN 978-0-07-140235-4.
Kondo M, Oshita F, Kato Y, Yamada K, Nomura I, Noda K (1999). "Early monocytopenia after chemotherapy as a risk factor for neutropenia". Am. J. Clin. Oncol. 22 (1): 103–5. doi:10.1097/00000421-199902000-00025. PMID 10025393.
Oguz A, Karadeniz C, Ckitak EC, Cil V (2006). "Which one is a risk factor for chemotherapy-induced febrile neutropenia in childhood solid tumors: early lymphopenia or monocytopenia?". Pediatr Hematol Oncol. 23 (2): 143–51. doi:10.1080/08880010500457673. PMID 16651243.

External links

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[1] Harrison's principles of internal medicine. New York: McGraw-Hill. 2005. p. 356. ISBN 978-0-07-140235-4.

[pmid10025393-2] Kondo M, Oshita F, Kato Y, Yamada K, Nomura I, Noda K (1999). "Early monocytopenia after chemotherapy as a risk factor for neutropenia". Am. J. Clin. Oncol. 22 (1): 103–5. doi:10.1097/00000421-199902000-00025. PMID 10025393.

[pmid16651243-3] Oguz A, Karadeniz C, Ckitak EC, Cil V (2006). "Which one is a risk factor for chemotherapy-induced febrile neutropenia in childhood solid tumors: early lymphopenia or monocytopenia?". Pediatr Hematol Oncol. 23 (2): 143–51. doi:10.1080/08880010500457673. PMID 16651243.