A macroglobulin is a plasma globulin of high molecular weight.
Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood vessels when temperature drops (as in cryoglobulinaemia).
Other macroglobulins include alpha-2 macroglobulin, which is elevated in nephrotic syndrome, diabetes, severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease.
- "Definition: macroglobulin from Online Medical Dictionary". Archived from the original on June 24, 2008.
- Macroglobulins at the US National Library of Medicine Medical Subject Headings (MeSH)