List of adverse effects of paroxetine

This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.[1][2][3][4]

Very common

Very common (>10% incidence) adverse effects include:

  • Nausea
  • Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.[5]
  • Impaired concentration
  • Somnolence is more common with paroxetine than with other SSRIs.[6]
  • Insomnia
  • Headache
  • Dry mouth

Common

Common (1–10% incidence) adverse effects include:

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

Rare

Rare (0.01–0.1% incidence) adverse effects include:

Very rare

Rare (<0.01% incidence) adverse effects include:

References

  1. "PRODUCT INFORMATION PAROXETINE SANDOZ 20mg FILM-COATED TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 18 January 2012. Retrieved 22 November 2013.
  2. "PAROXETINE (paroxetine hydrochloride hemihydrate) tablet, film coated [Mylan Institutional Inc.]". DailyMed. Mylan Institutional Inc. January 2012. Retrieved 22 November 2013.
  3. "Paroxetine 20 mg Tablets - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 21 March 2013. Retrieved 22 November 2013.
  4. "Paxil, Paxil CR (paroxetine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 November 2013.
  5. Taylor, David; Paton, Carol; Shitij, Kapur (2012). The Maudsley prescribing guidelines in psychiatry. Prescribing guidelines in psychiatry (11th ed.). West Sussex: Wiley-Blackwell. ISBN 978-0-470-97948-8. OCLC 780368001.
  6. Ciraulo, Domenic A.; Shader, Richard Irwin, eds. (2011). Pharmacotherapy of Depression (2nd ed.). New York, NY: Humana Press. doi:10.1007/978-1-60327-435-7. ISBN 978-1-60327-434-0. OCLC 697508697.
  7. Vesely C, Fischer P, Goessler R, Kasper S (February 1997). "Mania associated with serotonin selective reuptake inhibitors". J Clin Psychiatry. 58 (2): 88. doi:10.4088/JCP.v58n0206e. PMID 9062382.
  8. Ramasubbu R (November 2004). "Antidepressant treatment-associated behavioural expression of hypomania: a case series". Prog Neuropsychopharmacol Biol Psychiatry. 28 (7): 1201–7. doi:10.1016/j.pnpbp.2004.06.015. PMID 15610935.
  9. Grubbs JH (April 1997). "SSRI-induced mania". J Am Acad Child Adolesc Psychiatry. 36 (4): 445. doi:10.1097/00004583-199704000-00003. PMID 9100415.
  10. "PAXIL (paroxetine hydrochloride) Tablets and Oral Suspension: PRESCRIBING INFORMATION" (PDF). Research Triangle Park, NC: GlaxoSmithKline. August 2007. Archived from the original (PDF) on 2011-08-25. Retrieved 2007-08-14.
  11. Morishita S, Arita S (October 2003). "Induction of mania in depression by paroxetine". Hum Psychopharmacol. 18 (7): 565–8. doi:10.1002/hup.531. PMID 14533140.
  12. Olivera AA (1996). "A case of paroxetine-induced akathisia". Biol. Psychiatry. 39 (10): 910. doi:10.1016/0006-3223(96)84504-5. PMID 8860197.
  13. Baldassano CF, Truman CJ, Nierenberg A, Ghaemi SN, Sachs GS (1996). "Akathisia: a review and case report following paroxetine treatment". Compr Psychiatry. 37 (2): 122–4. doi:10.1016/S0010-440X(96)90572-6. PMID 8654061.
  14. Tabachnick, Barbara (September 1998). "Sound Sensitivity" (PDF). Tinnitus Today. Archived from the original (PDF) on 2013-11-01. Retrieved 2013-10-30.
  15. "Important Safety Information about Paxil CR". GlaxoSmithKline. Archived from the original on July 15, 2007.
  16. Nishida T, Wada M, Wada M, Ito H, Narabayashi M, Onishi H (2008). "Activation syndrome caused by paroxetine in a cancer patient". Palliat Support Care. 6 (2): 183–5. doi:10.1017/S1478951508000278. PMID 18501054.
  17. Ochiai Y, Katsu H, Okino S, Wakutsu N, Nakayama K (2003). "[Case of prolonged recovery from serotonin syndrome caused by paroxetine]". Seishin Shinkeigaku Zasshi (in Japanese). 105 (12): 1532–8. PMID 15027311.
  18. Terao T, Hikichi T (2007). "Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (1): 295–6. doi:10.1016/j.pnpbp.2006.07.007. PMID 16916568.
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