Gitoformate
Gitoformate (INN, or pentaformylgitoxin, trade name Dynocard) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat).[1] Produced by Madaus, it is not available in the US, and does not seem to be available in Europe either.
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Trade names | Dynocard |
Other names | Gitoxin 3',3'',3''',4''',16-pentaformate |
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ECHA InfoCard | 100.030.397 |
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Formula | C46H64O19 |
Molar mass | 920.989 g/mol g·mol−1 |
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Chemistry
Gitoformate is a derivative of the glycoside gitoxin, with five of the six free hydroxyl groups formylated, one on the aglycon and four on the sugar.[2][3] Gitoxin, a cardiac glycoside from the woolly foxglove (Digitalis lanata), has an aglycon of the cardenolide type named gitoxigenin, which is also the aglycon of lanatoside B, another Digitalis lanata glycoside.[4]
References
- Rietbrock, N.; Woodcock, B. G.; Hrazdil, U. (1984). "Gitoformate and digitoxin as alternatives to kidney-dependent glycosides in the therapy of cardiac insufficiency". Arzneimittel-Forschung. 34 (8): 915–917. PMID 6541927.
- Dei Cas, L.; Affatato, A.; Buia, E.; Casciarri, G.; Faggiano, P.; Giunti, G.; Metra, M.; Pelagatti, T.; Quinzanini, M. (1984). "Plasma levels of gitoxin (by RIA and rubidium-86 uptake) and systolic time after treatment with a single dose of gitoformate". Cardiologia (Rome, Italy). 29 (5–6): 291–300. PMID 6542412.
- CID 91540 from PubChem
- William O. Foye,Thomas L. Lemke, David A. Williams (2008). Foye's principles of medicinal chemistry. p. 699. ISBN 978-0-7817-6879-5.CS1 maint: uses authors parameter (link)
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