Fenticlor

Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine.

Fenticlor
Clinical data
Routes of
administration		topical
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.336
Chemical and physical data
FormulaC12H8Cl2O2S
Molar mass287.16 g/mol g·mol−1
Melting point174 °C (345 °F)

Synthesis

It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride.[1] It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.[2][3]

Safety

LD50 (rats, oral) = 3250 mg/kg.[1] It may cause photosensitivity [4]

References
  1. Helmut Fiege; Heinz-Werner Voges; Toshikazu Hamamoto; Sumio Umemura; Tadao Iwata; Hisaya Miki; Yasuhiro Fujita; Hans-Josef Buysch; Dorothea Garbe (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313.
  2. Muth, DE 568944 (1931 to I. G. Farben).
  3. Dunning, F.; Dunning, B.; Drake, W. E. (1931). "Preparation and Bacteriological Study of Some Symmetrical Organic Sulfides". Journal of the American Chemical Society. 53 (9): 3466. doi:10.1021/ja01360a035.
  4. Burry JN (June 1974). "Letter: Fenticlor, actinic reticuloid, and antihistamines". Br Med J. 2 (5918): 556–7. doi:10.1136/bmj.2.5918.556-c. PMC 1610938. PMID 4152080.
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