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Hirudins
From WikEM
Background
- Direct thrombin inhibitors
Drugs
- Hirudin
- Lepirudin
- Argatroban
Indications
- HIT
- Unstable angina/NSTEMI/PCI
Complications
- Bleeding
- Majority of bleeding events occur at invasive sites
- No antidote available
- Minor bleeding
- Stop infusion
- Major bleeding
- Give FFP or PCC
Pharmacology
- Half-life is ~2hr
