Fresh frozen plasma

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General

Adult Dosing

  • Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Indications

  • Rapid reversal of warfarin over-anticoagulation
  • Bleeding and multiple coagulation defects
  • Correction of coagulation defects for which no specific factor is available
  • Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

Comments

  • Contains all coagulation factors and fibrinogen
    • 40 mL/kg raises any factor by 100% (each unit is ~200mL)
  • May cause fluid overload
  • ABO compatibilty a must but crossmatch before transfusing not
  • INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised[1]
  • Retains active coagulation factors for up to 5 days after being thawed

See Also

References

  1. Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9.