Research

Check out the following list of publications if you are interested in research, immunization recommendations, and other references specific to preventing whooping cough in infants.

General

• Cortese MM, Bisgard KM. Pertussis. In: Wallace RB, Kohatsu N, Kast JM, ed. Maxcy-Rosenau-Last Public Health & Preventive Medicine, Fifteenth Edition. The McGraw-Hill Companies, Inc. 2008;111-14.
• Tanaka M, Vitek CR, Pascual FB, et al. Trends in pertussis among infants in the United States, 1980-1999. JAMA. 2003;290:2968–75.

Birth Dose Strategy to Prevent Whooping Cough in Babies

• Halasa NB, O’Shea A, Shi JR, LaFleur BJ, Edwards KM. Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine. J Pediatr. 2008;153(3):327-32.
• Knuf M, Schmitt HJ, Wolter J, et al. Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants. J Pediatr. 2008;152(5):655-60.
• Halperin BA, Halperin SA. The reemergence of pertussis and infant deaths: is it time to immunize pregnant women? Future Microbiol. 2011;6(4):367-9.
• Munoz FM. Vaccination during pregnancy. Womens Health (Lond Engl). 2007;3(2):227-41.
• Mooi FR, de Greeff SC.  The case for maternal vaccination against pertussis. Lancet Infect Dis. 2007;7(9):614-24.

Cocooning

• Blain AE, Lewis M, Banerjee E, et al. An assessment of the cocooning strategy for preventing infant pertussis — United States, 2011. Clin Infect Dis. 2016;63(suppl 4):S221–6.
• Healy CM, Rench MA, Wootton SH, Castagnini LA. Evaluation of the impact of a pertussis cocooning program on infant pertussis infection. Pediatr Infect Dis J. 2015;34(1):22–6.

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Immunization Recommendations for Whooping Cough

• CDC. Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccine in Pregnant Women — Advisory Committee on Immunization Practices (ACIP), 2012. MMWR. 2013;62(07):131–135.
• CDC. General Recommendations on Immunizations: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2011;60(RR02):1–60.
• CDC. Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccine in Pregnant Women and Persons Who Have or Anticipate Having Close Contact with an Infant Aged Less than 12 Months — Advisory Committee on Immunization Practices (ACIP), 2011. MMWR. 2011;60(41):1424–6.

Immunogenicity and Effectiveness

• Baxter R, Bartlett J, Fireman B, Lewis E, Klein NP. Effectiveness of vaccination during pregnancy to prevent infant pertussis. Pediatrics. 2017;139(5):pii: e20164091.
• Winter K, Cherry JD, Harriman K. Effectiveness of prenatal Tdap vaccination on pertussis severity in infants. Clin Infect Dis. 2016;64(1):9–14.
• Winter K, Cherry JD, Harriman K. Effectiveness of prenatal versus postpartum Tdap vaccination in preventing infant pertussis. Clin Infect Dis. 2016;64(1):3–8.
• Dabrera G, Amirthalingam G, Andrews N, et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012-2013. Clin Infect Dis. 2015;60(3):333–7.
• Amirthalingam G, Andrews N, Campbell H, et al. Effectiveness of maternal pertussis vaccination in England: An observational study. Lancet. 2014;384(9953):1521–28.
• Munoz FM, Bond NH, Maccato M, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: A randomized clinical trial. JAMA. 2014;311(17):1760–9.

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Maternal Vaccination to Prevent Whooping Cough in Babies

• McIntyre PB, Clark TA. Pertussis vaccine in pregnancy—first dose for every infant? Lancet. 2014;384(9953):1484–6.
• Halperin BA, Halperin SA. The reemergence of pertussis and infant deaths: is it time to immunize pregnant women? Future Microbiol. 2011;6(4):367-9.
• Halperin BA, Morris A, Mackinnon-Cameron D, et al. Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum women. Clin Infect Dis. 2011;53(9):885–92.
• Healy CM, Rench MA, Baker CJ. Importance of timing of maternal Tdap immunization and protection of young infants. Clin Infect Dis. 2013;56:539–44.
• Libster R, Edwards KM. How can we best prevent pertussis in infants? Clin Infect Dis. 2012;54(1):85–7.
• Mooi FR, de Greeff SC. The case for maternal vaccination against pertussis. Lancet Infect Dis. 2007;7(9):614-24.
• Munoz FM. Vaccination during pregnancy. Womens Health (Lond Engl). 2007;3(2):227-41.
• Van Rie A, Wendelboe AM, Englund JA. Role of maternal pertussis antibodies in infants. Pediatr Infect Dis J. 2005;24(5 Suppl):S62–5.

Safety

• DeSilva M, Vazquez-Benitez G, Nordin JD, et al. Maternal Tdap vaccination and risk of infant morbidity. Vaccine. 2017;35(29):3655–60.
• McMillan M, Clarke M, Parrella A, Fell DB, Amirthalingam G, Marshall HS. Safety of tetanus, diphtheria, and pertussis vaccination during pregnancy: A systematic review. Obstet Gynecol. 2017;129(3):560–73.
• DeSilva M, Vazquez-Benitez G, Nordin JD, et al. Tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring. JAMA. 2016;316(17):1823–5.
• Sukumaran L, McCarthy NL, Kharbanda EO, et al. Safety of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis and influenza vaccinations in pregnancy. Obstet Gynecol. 2015;126(5):1069–74.
• Sukumaran L, McCarthy NL, Kharbanda EO, et al. Association of Tdap vaccination with acute events and adverse birth outcomes among pregnant women with prior tetanus-containing immunizations. JAMA. 2015;314(15):1581–7.
• Morgan JL, Baggari SR, McIntire DD, Sheffield JS. Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination. Obstet Gynecol. 2015;125(6):1433–8.
• Czeizel AE, Rockenbauer M. Tetanus toxoid and congenital abnormalities. Int J Gynecol Obstet. 1999;64:253–8.
• Donegan K, King B, Bryan P. Safety of pertussis vaccination in pregnant women in UK: Observational study. BMJ. 2014;349:g4219.
• Hardy-Fairbanks AJ, Pan SJ, Decker MD, et al. Immune responses in infants whose mothers received Tdap vaccine during pregnancy. Pediatr Infect Dis J. 2013;32:1257-60.
• Kharbanda EO, Vazquez-Benitez G, Lipkind HS, et al. Evaluation of the Association of Maternal Pertussis Vaccination With Obstetric Events and Birth Outcomes. JAMA. 2014;312(18):1897–1904.
• Kharbanda EO, Vazquez-Benitez G, Lipkind H, et al. Receipt of pertussis vaccine during pregnancy across 7 Vaccine Safety Datalink Sites.  Prev Med. 2014;67:316–9.
• Liang J. Overview of Tdap use during pregnancy: unpublished and recent data. Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; February 23, 2011.
• Moro P. Safety of Tdap vaccine during pregnancy: enhanced surveillance in VAERS presented to the Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; February 26, 2014.
• Munoz FM, Bond NH, Maccato M, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: A randomized clinical trial. JAMA. 2014;311(17):1760–9.
• Rasmussen S. Safety of maternal Tdap vaccination for mother and fetus presented to the Advisory Committee on Immunization Practices (ACIP), Atlanta, GA; June 22, 2011.
• Schofield FD, Tucker VM, Westbrook GR. Neonatal tetanus in New Guinea. Effect of active immunization in pregnancy. Br Med J. 1961;2:785–9.
• Silveria CM, Caceres VM, Dutra MG, Lopes-Camelo J, Castilla EE. Safety of tetanus toxoid in pregnant women: a hospital-based case-control study of congenital anomalies. Bull World Health Organ. 1995;73:605–8.
• Shakib JH, Korgenski K, Sheng X, Varner MW, Pavia AT, Byington CL. Tetanus, diphtheria, acellular pertussis vaccine during pregnancy: pregnancy and infant health outcomes. J Pediat. 2013; 163(5):1422–26.
• Zheteyeva YA, Moro PL, Tepper NK, et al. Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women . Am J Obstet Gynecol. 2012;207(1):59.e1–7.

Note: Presentations given to the Advisory Committee on Immunization Practices are available online or by request to acip@cdc.gov.

Source of Whooping Cough Infection for Babies

• Skoff TH, Kenyon C, Cocoros N, et al. Sources of infant pertussis infection in the United States. Pediatrics. 2015;136(4):635–41.
• Bisgard KM, Pascual FB, Ehresmann KR, et al. Infant pertussis: who was the source? Pediatr Infect Dis J. 2004;23:985–89.
• Wendelboe AM, Njamkepo E, Bourillon A, et al. Transmission of Bordetella pertussis to young infants. Pediatr Infect Dis J. 2007;26:293–99.

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