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Registry of Toxic Effects of Chemical Substances (RTECS)

Manganese, monosulfate, monohydrate

RTECS #

OP0893500

CAS #

10034-96-5

Updated

September 201

Molecular Weight

169.02

Molecular Formula

O4S·Mn·H2O

Synonyms

Manganese (II) sulfate monohydrate
Manganese sulfate monohydrate
Manganese(2+) sulfate monohydrate
Manganous sulfate monohydrate
Sulfuric acid, manganese(2+) salt (1:1), monohydrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse718 mg/kg/7D-continuousMUREAV 240,159,1990
Cytogenetic Analysisovary/hamster180 mg/LEMMUEG 10(Suppl 10),1,1987
gene conversion and mitotic recombination/Saccharomyes cerevisiae40 µmol/LMUREAV 137,47,1984
micronucleus testoral/mouse205 mg/kg/24H-continuousMUREAV 240,159,1990
mutation in microorganisms/Saccharomyes cerevisiae40 µmol/L (-enzymatic activation step)MUREAV 137,47,1984
sister chromatid exchangeovary/hamster5 mg/LEMMUEG 10(Suppl 10),1,1987
sperm morphologyoral/mouse513 mg/kg/5D-continuousMUREAV 240,159,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 513 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 240,159,1990

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1314 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors		NTPTR* NTP-TR-428,1993
oral/mouse lowest published toxic dose: 1297800 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors		NTIS** PB94-217148
oral/mouse lowest published toxic dose: 1622250 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors		NTIS** PB94-217148

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lowest published toxic dose: 2 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport		TOLED5 148,41,2004
intravenous/mouse lowest published toxic dose: 2 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		TOLED5 148,41,2004
intravenous/rat lowest published toxic dose: 4.5 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TOSCF2 73,378,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/monkey lowest published toxic concentration: 4.62 mg/m3/6H/65D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOSCF2 92,201,2006
inhalation/monkey lowest published toxic concentration: 4.62 mg/m3/6H/33D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesTOSCF2 92,201,2006
inhalation/monkey lowest published toxic concentration: 4.62 mg/m3/6H/15D- intermittentBlood: Other changesTOSCF2 92,201,2006
inhalation/rat lowest published toxic concentration: 0.5 mg/m3/45D- intermittentRelated to Chronic Data: Changes in testicular weightTXAPA9 197,113,2004
inhalation/rat lowest published toxic concentration: 0.1 mg/m3/90D- intermittentBrain and Coverings: Changes in brain weightTXAPA9 197,113,2004
inhalation/rat lowest published toxic concentration: 0.478 mg/m3/13W- intermittentOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		INHTE5 16,481,2004
inhalation/rat lowest published toxic concentration: 0.01 mg/m3/13W- intermittentBrain and Coverings: Other degenerative changesINHTE5 16,481,2004
oral/mouse lowest published toxic dose: 546 gm/kg/13W- continuousLiver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Other changes		NTPTR* NTP-TR-428,1993
oral/rat lowest published toxic dose: 42 gm/kg/14D- continuousLiver: Changes in liver weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count		NTPTR* NTP-TR-428,1993
oral/rat lowest published toxic dose: 28437 mg/kg/13W- continuousLung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTPTR* NTP-TR-428,1993

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Mn)/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Mn)/m3 (inhal)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg(Mn)/m3 (dust), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg(Mn)/m3 (fume), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg(Mn)/m3, inhal. dust, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg(Mn)/m3, resp. dust, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.2 mg(Mn)/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg(Mn)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg(Mn)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.2 mg(Mn)/m3, (total dust);time-weighted average 0.1 mg(Mn)/m3, (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Mn)/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Mn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1601; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 6; Total Number of Employees Exposed 893; Total Number of Female Employees Exposed 398

Status in Federal Agencies

OrganizationReference
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat

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