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Registry of Toxic Effects of Chemical Substances (RTECS)

Manganese dioxide

RTECS #

OP0350000

CAS #

1313-13-9

Updated

September 201

Molecular Weight

86.94

Molecular Formula

MnO2

Synonyms

Black manganese oxide
BOG manganese
Braunstein (German)
Bruinsteen (Dutch)
C.I. 77728
C.I. Pigment Black 14
C.I. Pigment Brown 8
Cement Black
Mangaanbioxyde (Dutch)
Mangaandioxyde (Dutch)
Mangandioxid (German)
Manganese (biossido di) (Italian)
Manganese (bioxyd de) (French)
Manganese (diossido di) (Italian)
Manganese (dioxyde de) (French)
Manganese binoxide
Manganese Black
Manganese peroxide
Manganese superoxide
Manganese(IV) oxide
Pyrolusite Brown

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 49 mg/m3/7H (75D prior to copulation/1-18D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral		FEPRA7 39,623,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published lethal dose: 50 mg/kgLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema		GISAAA 20(1),25,1955
intravenous/rabbit lowest published lethal dose: 45 mg/kg85KYAH 11,899,1989
oral/rat lethal dose (50 percent kill): 3478 mg/kgUSXXAM #6441582
subcutaneous/mouse lethal dose (50 percent kill): 422 mg/kgZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/man lowest published toxic concentration: 0.66 mg/m3/14Y- intermittentBrain and Coverings: Recordings from specific areas of CNSNRTXDN 28,126,2007
inhalation/monkey lowest published toxic concentration: 0.6 mg/m3/1H/17W- intermittentBehavioral: Tremor

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)		VCVN5* -,411,1989
inhalation/rat lowest published toxic concentration: 1800 µg/m3/24H/35D- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 49(12),53,1984
inhalation/rat lowest published toxic concentration: 7 mg/m3/24H/34W- continuousBehavioral: Alteration of classical conditioningVCVN5* -,411,1989
intramuscular/human lowest published toxic dose: 21 µg/m3/5.3Y- intermittentBehavioral: Change in psychophysiological tests

Nutritional and Gross Metabolic: Changes in: Fe		BJIMAG 49,25,1992
subcutaneous/monkey lowest published toxic dose: 150 mg/kg/3W- intermittentBehavioral: Change in motor activity (specific assay)VCVN5* -,411,1989
subcutaneous/mouse lowest published toxic dose: 6000 mg/kg/12D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,411,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Mn)/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Mn)/m3 (inhal)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMRL** TR-73-125,1973
TOXICOLOGY REVIEW85DHAX Mn,1,1973
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWJTEHF8 70,594,2007
TOXICOLOGY REVIEWHBTME* ,177,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airceiling concentration 5 mg(Mn)/m3DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg(Mn)/m3 (dust), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg(Mn)/m3 (fume), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg(Mn)/m3, inhal. dust, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg(Mn)/m3, resp. dust, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.2 mg(Mn)/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg(Mn)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg(Mn)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.2 mg(Mn)/m3, (total dust);time-weighted average 0.1 mg(Mn)/m3, (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Mn)/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Mn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 44030; Number of Industries 41; Total Number of Facilities 3347; Number of Occupations 50; Total Number of Employees Exposed 71963; Total Number of Female Employees Exposed 15526
National Occupational Hazard Survey 1974Hazard Code 44030; Number of Industries 48; Total Number of Facilities 3820; Number of Occupations 60; Total Number of Employees Exposed 53685

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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