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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrazine

RTECS #

MU7175000

CAS #

302-01-2

Updated

December 2013

Molecular Weight

32.06

Molecular Formula

H4N2

Synonyms

Hydrazine (ACGIH:OSHA)
Hydrazine fume
Hydrazyna (Polish)
Levoxine
Nitrogen hydride
Oxytreat 35
RCRA waste number U133

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 50%/1HTPKVAL 4,65,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA Damageliver/rat3 mmol/LMUREAV 113,357,1983
DNA Damageintraperitoneal/mouse100 mg/kgMUREAV 415,1,1998
DNA Damageoral/mouse100 mg/kgMUREAV 415,1,1998
DNA Damageoral/hamster15 mg/kgPAACA3 24,59,1983
DNA Damagelymphocyte/mammal (species unspecified)95 pphBBACAQ 174,591,1969
DNA Damagelung/rat0.5 mmol/L/20HMUREAV 605,94,2006
DNA Damagelung/human0.5 mmol/L/20HMUREAV 605,94,2006
DNA Damageoral/rat30 mg/kgMUREAV 605,94,2006
DNA inhibitionoral/rat60 mg/kgCRNGDP 4,953,1983
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA inhibitionHeLa cell/human50 µmol/LCNREA8 44,59,1984
morphological transformliver/human80 µg/LBJCAAI 37,873,1978
morphological transformother cell types/human35 mg/LITCSAF 17,719,1981
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
mutation in mammalian somatic cellslymphocyte/mouse1 mmol/LMUREAV 89,321,1981
mutation in microorganisms/Saccharomyes cerevisiae200 mmol/L (-enzymatic activation step)MUREAV 93,339,1982
mutation in microorganisms/Haemophilus influenzae2 mmol/L (-enzymatic activation step)MUREAV 30,9,1975
mutation in microorganisms/Other microorganisms70 µg/L (-enzymatic activation step)MUREAV 173,233,1986
mutation in microorganisms/Salmonella typhimurium120 µg/plate (-enzymatic activation step)BIZNAT 97,137,1978
mutation in microorganisms/Escherichia coli4300 µmol/L (+enzymatic activation step)TOLED5 31,131,1986
other mutation test systems/Escherichia coli80 pmol/tubeMUREAV 147,79,1985
other mutation test systems/Bacillus subtilis10 mmol/LMUREAV 5,343,1968
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster10 mmol/LMUREAV 16,363,1972
Unscheduled DNA Synthesisoral/rat60 mg/kgCRNGDP 4,953,1983
Unscheduled DNA Synthesislung/rat250 µg/LNTIS** AD-A075-605
Unscheduled DNA Synthesisovary/hamster250 µg/LNTIS** AD-A075-605
Unscheduled DNA Synthesislung/hamster250 µg/LNTIS** AD-A075-605

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 4 mg/m3/2H (7-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)GISAAA 39(10),23,1974
inhalation/rat 1 mg/m3/24H (1-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death		GISAAA 39(10),23,1974
inhalation/hamster 1 ppm/6H (1Y male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFAATDF 5,1050,1985
inhalation/rat 1 mg/m3 (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVN5* -,20,1989
intraperitoneal/mouse 48 mg/kg (6-9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		NTIS** AD-A084-023
intraperitoneal/mouse 80 mg/kg (6-9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system		NTIS** AD-A084-023
intraperitoneal/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)APTOD9 19,A21,1980
intraperitoneal/rat 50 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)APTOD9 19,A21,1980
intraperitoneal/rat 30 mg/kg (7-9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system		NTIS** AD-A119-706
intraperitoneal/rat 30 mg/kg (7-9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		NTIS** AD-A119-706
skin/rat 50 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** AD-A119-706
subcutaneous/rat 80 mg/kg (11-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)		AEHLAU 21,615,1970

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors		FAATDF 5,1050,1985
inhalation/hamster toxic concentration (other than lowest): 5 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		PAACA3 21,74,1980
inhalation/mouse lowest published toxic concentration: 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		PAACA3 21,74,1980
inhalation/rat lowest published toxic concentration: 5 ppm/6H/1Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors		FAATDF 5,1050,1985
inhalation/rat toxic concentration (other than lowest): 5 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		PAACA3 21,74,1980
inhalation/rat toxic concentration (other than lowest): 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		PAACA3 21,74,1980
intraperitoneal/mouse lowest published toxic dose: 400 mg/kg/5W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Blood: Leukemia		UICMAI 7,180,1967
oral/mouse lowest published toxic dose: 1951 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease		IJCNAW 9,109,1972
oral/rat lowest published toxic dose: 900 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		EXPADD 33,133,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 252 ppm/4HEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea		AMIHAB 12,609,1955
inhalation/mouse lethal concentration (50 percent kill): 1000 mg/m3/2HVCVN5* -,20,1993
inhalation/mouse lethal concentration (50 percent kill): 320 mg/m3/4HVCVN5* -,20,1993
inhalation/mouse lethal concentration (50 percent kill): 330 gm/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Liver: Other changes		TPKVAL 4,65,1962
inhalation/mouse Lowest published lethal concentration: 1.5 gm/m3/2HKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Blood: Changes in spleen		TPKVAL 4,65,1962
inhalation/mouse lowest published toxic concentration: 0.65 gm/m3/2HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Fatty liver degeneration		TPKVAL 4,65,1962
inhalation/mouse lowest published toxic concentration: 0.02 gm/m3TPKVAL 4,65,1962
inhalation/rat lethal concentration (50 percent kill): 750 gm/m3/4HBrain and Coverings: Increased intracranial pressure

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance		TPKVAL 4,65,1962
inhalation/rat Lowest published lethal concentration: 0.02 gm/m3Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage		TPKVAL 4,65,1962
inhalation/rat Lowest published lethal concentration: 1.5 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.65 gm/m3/2HBehavioral: Alteration of classical conditioningTPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 20000 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Behavioral: Excitement

Behavioral: Tetany		VCVN5* -,20,1993
inhalation/rat lethal concentration (50 percent kill): 130 mg/m3/2HVCVN5* -,20,1993
inhalation/rat lowest published toxic concentration: 23 ppm/10MOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 16 ppm/30MOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 13 ppm/1HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 3.1 ppm/4HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 1.6 ppm/8HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 64 ppm/10MTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 45 ppm/30MTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 35 ppm/1HTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 8.9 ppm/4HTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 4.4 ppm/8HTOXID9 44,303,2005
inhalation/rat lethal concentration (50 percent kill): 570 ppm/4HEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea		AMIHAB 12,609,1955
intramuscular/Dog lethal dose (50 percent kill): 16500 µg/kgGISAAA 16(6),53,1972
intramuscular/rabbit lethal dose (50 percent kill): 38500 µg/kgGISAAA 16(6),53,1972
intramuscular/rat lethal dose (50 percent kill): 53500 µg/kgGISAAA 16(6),53,1972
intraperitoneal/cat lowest published toxic dose: 20 mg/kgBehavioral: TetanyVCVN5* -,20,1993
intraperitoneal/mouse lethal dose (50 percent kill): 62 mg/kgMEPAAX 24,71,1973
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		TOXID9 72,94,2003
intraperitoneal/rat lethal dose (50 percent kill): 59 mg/kgMEPAAX 24,71,1973
intraperitoneal/rat lowest published toxic dose: 20 mg/kgBehavioral: Alteration of classical conditioningVCVN5* -,20,1993
intravenous/Dog lethal dose (50 percent kill): 25 mg/kgMEPAAX 24,71,1973
intravenous/Dog lowest published lethal dose: 25 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage		TPKVAL 4,65,1962
intravenous/mouse lowest published lethal dose: 55 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold		TPKVAL 4,65,1962
intravenous/mouse lethal dose (50 percent kill): 57 mg/kgMEPAAX 24,71,1973
intravenous/rabbit lethal dose (50 percent kill): 20 mg/kgAMIHBC 9,199,1954
intravenous/rat lethal dose (50 percent kill): 55 mg/kgMEPAAX 24,71,1973
intravenous/rat lowest published lethal dose: 55 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea		TPKVAL 4,65,1962
oral/mouse lowest published toxic dose: 250 mg/kgLiver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TXAPA9 204,135,2005
oral/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins		TOXID9 78,353,2004
oral/mouse lowest published toxic dose: 300 mg/kgLiver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport		TOXID9 78,353,2004
oral/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		TOXID9 72,94,2003
oral/mouse lethal dose (50 percent kill): 80 mg/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen		TPKVAL 4,65,1962
oral/mouse lethal dose (50 percent kill): 59 mg/kgMEPAAX 24,71,1973
oral/mouse lethal dose (50 percent kill): 59 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight		VCVN5* -,20,1993
oral/rat lethal dose (50 percent kill): 60 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight		VCVN5* -,20,1993
oral/rat lowest published toxic dose: 90 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TXAPA9 204,135,2005
oral/rat lethal dose (50 percent kill): 60 mg/kgMEPAAX 24,71,1973
oral/rat lowest published toxic dose: 75 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainCRTOEC 14,975,2001
oral/rat lowest published toxic dose: 90 mg/kgKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Blood: Changes in other cell count (unspecified)		CRTOEC 14,975,2001
oral/rat lowest published toxic dose: 120 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Other changes		CRTOEC 14,975,2001
skin/Dog lowest published lethal dose: 96 mg/kgTXAPA9 21,186,1972
skin/Dog lowest published toxic dose: 3 mg/kgBehavioral: Tetany

Behavioral: Alteration of classical conditioning		VCVN5* -,20,1993
skin/guinea pig lethal dose (50 percent kill): 190 mg/kgBehavioral: Convulsions or effect on seizure thresholdXAWPA2 CWL 2-10,1958
skin/rabbit lethal dose (50 percent kill): 91 mg/kgAMIHBC 9,199,1954
subcutaneous/mouse lowest published toxic dose: 30 mg/kgBlood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Increase in cellular immune response		TXCYAC 172,35,2002
unreported route/mouse lethal dose (50 percent kill): 200 mg/kgBJCAAI 6,160,1952

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 14 ppm/6H/26W- intermittentBehavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 10,476,1954
inhalation/guinea pig lowest published toxic concentration: 14 ppm/6H/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAMIHBC 10,476,1954
inhalation/guinea pig lowest published toxic concentration: 5 mg/m3/24H/59D- continuousLung, Thorax, or Respiration: Other changesVCVN5* -,20,1989
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/1Y- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes		NTIS** AD-A086-341
inhalation/monkey lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/mouse lowest published toxic concentration: 130 mg/m3/1H/17W- intermittentBlood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count		VCVN5* -,20,1989
inhalation/mouse lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/mouse lowest published toxic concentration: 14 ppm/6H/5W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAMIHBC 10,476,1954
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/30D- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/91D- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.0005 gm/m3/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.0005 gm/m3/213D- intermittentBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage		TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/rat lowest published toxic concentration: 5 ppm/6H/26W- intermittentBehavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 10,476,1954
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/30D- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in bone marrow not included in above		GISAAA 40(3),29,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,127,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,991,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,223,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,991,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,991,1999
TOXICOLOGY REVIEWAMIHBC 9,199,1954
TOXICOLOGY REVIEWATXKA8 28,135,1971
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,536,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,719,1996
TOXICOLOGY REVIEWISMEA* 10,302,2008
TOXICOLOGY REVIEWMUTAEX 25,335,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (1.3 mg/m3) (skin)DTLVS* 3,127,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 ppm (0.013 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 ppm (0.13 mg/m3);KZW 0.4 ppm (0.52 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 ppm (0.013 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.013 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.13 mg/m3), short term exposure limit 0.3 ppm (0.4 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.13 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.13 mg/m3), carc, skin, sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.13 mg/m3), skin, 2B carc, s1 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.13 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.1 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 ppm (0.013 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.13 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.01 ppm (0.013 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.13 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.02 ppm (0.03 mg/m3);short term exposure limit 0.1 ppm (0.13 mg/m3), carc, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-airCarcinogen ceiling concentration 0.03 ppm/120MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 38110; Number of Industries 44; Total Number of Facilities 2515; Number of Occupations 46; Total Number of Employees Exposed 60490; Total Number of Female Employees Exposed 2841
National Occupational Hazard Survey 1974Hazard Code 38110; Number of Industries 37; Total Number of Facilities 2134; Number of Occupations 27; Total Number of Employees Exposed 11185

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101025/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8619;8EHQ-0593-9056
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrazine, 3503
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #108
OSHA ANALYTICAL METHOD #20

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