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Registry of Toxic Effects of Chemical Substances (RTECS)

Glutaraldehyde

RTECS #

MA2450000

CAS #

111-30-8

Updated

September 201

Molecular Weight

100.13

Molecular Formula

C5H8O2

Synonyms

1,3-Diformylpropane
1,5-Pentanedial
1,5-Pentanedione
Aldehyd glutarowy (Polish)
Cidex
Glutaral
Glutaraldehyd (Czech)
Glutaraldehyde (ACGIH)
Glutardialdehyde
Glutaric dialdehyde
NCI-C55425
Potentiated acid glutaraldehyde
Sonacide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeUCDS** 1/30/1970
eye /rabbit 250 µg/24H severe85JCAE -,272,1986
eye /woman 200 ppbTOXID9 72,292,2003
skin /human 1%/2DCODEDG 61,163,2009
skin /human 6 mg/3D- intermittent severe85DKA8 -,127,1977
skin /mouse 2.5%/3DTXCYAC 279,115,2011
skin /rabbit 13 mg open irritation test mildUCDS** 1/30/1970
skin /rabbit 2 mg/24H severe85JCAE -,272,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster160 µg/LENMUDM 7,1,1985
DNA Damagelymphocyte/human10 µmol/LEMMUEG 17(Suppl 19),71,1991
DNA Damageleukocyte/human5 µmol/LMUREAV 468,93,2000
DNA Damageleukocyte/chicken8 pphCELLB5 5,45,1975
DNA Damagelymphocyte/mammal (species unspecified)2500 µmol/LMUREAV 283,131,1992
DNA Damagefibroblast/hamster2500 ppmSFCRAO 23,346,1970
DNA Damagefibroblast/hamster20 µmol/L/1HMUREAV 649,146,2008
DNA repair/Bacillus subtilis1 mg/LMUREAV 193,21,1988
micronucleus testfibroblast/hamster10 µmol/L/1HMUREAV 649,146,2008
mutation in mammalian somatic cellslymphocyte/mouse8 mg/LEMMUEG 11,91,1988
mutation in microorganisms/Salmonella typhimurium500 nmol/L (+enzymatic activation step)MUREAV 148,25,1985
mutation in microorganisms/Salmonella typhimurium150 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Escherichia coli62500 ng/plate (-enzymatic activation step)MUREAV 412,17,1998
mutation in microorganisms/Salmonella typhimurium0.05 mg/plate/48H (+enzymatic activation step)JAPTO* 22,45,2001
mutation in microorganisms/Salmonella typhimurium0.025 mg/plate/3D (-enzymatic activation step)MUREAV 521,19,2002
mutation in microorganisms/Salmonella typhimurium25 µg/plate/72H (-enzymatic activation step)MUTAEX 15,495,2000
other mutation test systemsother cell types/non-mammalian species50 mmol/LECREAL 95,233,1975
sister chromatid exchangeovary/hamster110 µg/LENMUDM 7,1,1985
sister chromatid exchangefibroblast/hamster10 µmol/L/1HMUREAV 649,146,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 875 mg/kg (35D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands		OYYAA2 12,11,1976
oral/rat 4370 mg/kg (35D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaOYYAA2 12,11,1976
oral/rat 1 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 63,147,1992
oral/mouse 50 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		TJADAB 22,51,1980
oral/mouse 8 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 22,51,1980
oral/rabbit 585 mg/kg (7-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		NTIS** OTS0526410
oral/rat 5.3 gm/kg (84D male/70D pre-4W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects		JTEHD6 61,107,2000
oral/rat 167.4 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects		JTEHD6 61,107,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2912 mg/kg/104W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains		TXCYAC 175,177,2002
oral/rat lowest published toxic dose: 2912 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains		TXCYAC 175,177,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 6 ppm/1.5HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		TXCYAC 279,115,2011
inhalation/rabbit lowest published toxic concentration: 500 ppmEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,404,1984
inhalation/rat lethal concentration (50 percent kill): 480 mg/m3/4HEPASR* 8EHQ-1290-1008
inhalation/woman lowest published toxic concentration: 200 ppbOlfaction: Other olfaction effectsTOXID9 72,292,2003
intraperitoneal/mouse lethal dose (50 percent kill): 13900 µg/kgIYKEDH 10,232,1979
intraperitoneal/rat lethal dose (50 percent kill): 17900 µg/kgIYKEDH 10,232,1979
intravenous/mouse lethal dose (50 percent kill): 15400 µg/kgOYYAA2 19,503,1980
intravenous/rat lethal dose (50 percent kill): 9800 µg/kgEPASR* 8EHQ-1290-1008
oral/duck lethal dose (50 percent kill): 820 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)		NTIS** OTS0526410-1
oral/guinea pig lethal dose (50 percent kill): 50 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement		GISAAA 52(3),77,1987
oral/mouse lethal dose (50 percent kill): 231 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,404,1984
oral/mouse lethal dose (50 percent kill): 100 mg/kgOYYAA2 19,503,1980
oral/rat lethal dose (50 percent kill): 140 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,404,1984
oral/rat lethal dose (50 percent kill): 134 mg/kgOYYAA2 19,503,1980
skin/mouse lowest published toxic dose: 1.25 mg/kgEye: Change in extra- ocular musclesTXCYAC 279,115,2011
skin/mouse lethal dose (50 percent kill): >5840 mg/kgSkin: After systemic exposure: Dermatitis, otherOYYAA2 12,11,1976
skin/rabbit lethal dose (50 percent kill): 560 µL/kgUCDS** 11/4/1971
skin/rat lethal dose (50 percent kill): >2500 mg/kgSkin: After systemic exposure: Dermatitis, otherOYYAA2 12,11,1976
subcutaneous/mouse lethal dose (50 percent kill): >590 mg/kgNIIRDN -,395,1995
subcutaneous/rat lethal dose (50 percent kill): >750 mg/kgNIIRDN -,395,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 16 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTPTR* NIH-93-3348
inhalation/mouse lowest published toxic concentration: 1000 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTPTR* NIH-93-3348
inhalation/mouse lowest published toxic concentration: 250 ppb/6H/2Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOXID9 48,341,1999
inhalation/rat lowest published toxic concentration: 5 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTPTR* NIH-93-3348
inhalation/rat lowest published toxic concentration: 1000 ppb/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTPTR* NIH-93-3348
inhalation/rat lowest published toxic concentration: 500 ppb/6H/2Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TOXID9 48,341,1999
oral/rat lowest published toxic dose: 12376 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOXID9 15,203,1995
oral/rat lowest published toxic dose: 54600 µg/kg/26W- intermittentLiver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 52(3),77,1987
oral/rat lowest published toxic dose: 11410 mg/kg/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0535072
oral/rat lowest published toxic dose: 122.5 mg/kg/1W- continuousBehavioral: Fluid intakeJTEHD6 61,107,2000
oral/rat lowest published toxic dose: 967 mg/kg/2W- continuousBehavioral: Food intake (animal)JTEHD6 61,107,2000
oral/rat lowest published toxic dose: 688.8 mg/kg/1W- continuousBehavioral: Food intake (animal)JTEHD6 61,107,2000
oral/rat lowest published toxic dose: 117.5 mg/kg/235D- intermittentEndocrine: Changes in thymus weight

Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)		VCVGK* -,404,1994
oral/rat lowest published toxic dose: 1547 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TXCYAC 175,177,2002
oral/rat lowest published toxic dose: 9282 mg/kg/78W- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TXCYAC 175,177,2002
skin/mouse lowest published toxic dose: 0.375 mg/kg/3D- intermittentBlood: Other changesTXCYAC 279,115,2011
skin/mouse lowest published toxic dose: 3.75 mg/kg/3D- intermittentBlood: Other changes

Skin: After topical application: Cutaneous sensitization (experimental)		TXCYAC 279,115,2011
subcutaneous/rat lowest published toxic dose: 175 mg/kg/35D- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia		OYYAA2 12,11,1976

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.05 ppm (sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDPIRDU 1(7),2,1981
TOXICOLOGY REVIEWCRTXB2 22,143,1992
TOXICOLOGY REVIEWJACTDZ 15,98,1996
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 589,136,2005
TOXICOLOGY REVIEWHPCQA4 38,527,2007
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.1 ppm (0.41 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.4 mg/m3);KZW 0.1 ppm (0.4 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.05 ppm (0.21 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.2 ppm (0.8 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDceiling concentration 0.1 ppm (0.42 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.4 mg/m3), VLE 0.2 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 ppm (0.21 mg/m3), 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.2 ppm (0.8 mg/m3), sen, NOV2011
Occupational Exposure Limit-JAPANceiling concentration 0.03 ppm, a1 sen, s1 sen, MAY2012
Occupational Exposure Limit-KOREAceiling concentration 0.2 ppm (0.7 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 0.2 ppm (0.7 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDshort term exposure limit 0.05 ppm, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.2 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 0,05 ppm (0,2 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENceiling concentration 0.2 ppm (0.8 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.21 mg/m3), KZG-week 0.1 ppm (0.42 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.25 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 ppm (0.2 mg/m3);short term exposure limit 0.05 ppm (0.2 mg/m3), sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLUTARALDEHYDE-airceiling concentration 0.2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84349; Number of Industries 35; Total Number of Facilities 9475; Number of Occupations 63; Total Number of Employees Exposed 367330; Total Number of Female Employees Exposed 265564
National Occupational Hazard Survey 1974Hazard Code 84349; Number of Industries 11; Total Number of Facilities 2069; Number of Occupations 25; Total Number of Employees Exposed 12954

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Glutaraldehyde, 2532
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NTP Toxicity studies, RPT# TOX-25, October 2000
OSHA ANALYTICAL METHOD #ID-64

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