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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(2+) oxide

RTECS #

GG2800000

CAS #

1307-96-6

Updated

September 201

Molecular Weight

74.93

Molecular Formula

CoO

Synonyms

C.I. 77322
C.I. Pigment Black 13
Cobalt Black
Cobalt monooxide
Cobalt monoxide
Cobaltous oxide
Monocobalt oxide
Zaffre

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/rat	lowest published toxic dose: 135 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	CNREA8 22,152,1962
intramuscular/rat	toxic dose: 90 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Musculoskeletal: Tumors Tumorigenic: Tumors at site of application	CNREA8 22,158,1962

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/mouse	lowest published lethal dose: 400 mg/kg		CNREA8 22,152,1962
intratracheal/rat	lowest published lethal dose: 50 mg/kg		VCVN5* -,452,1989
intratracheal/rat	lowest published toxic dose: 25 mg/kg	Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Fibrosing alveolitis	VCVN5* -,452,1989
oral/Dog	lowest published lethal dose: 89 mg/kg		EQSSDX 1,1,1975
oral/rat	lethal dose (50 percent kill): 202 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 20,311,1982
oral/rat	lethal dose (50 percent kill): 202 mg/kg	Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Hemorrhage	VCVN5* -,453,1989
subcutaneous/mouse	lethal dose (50 percent kill): 125 mg/kg		ZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic dose: 50 mg/m³/8H/35D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555434
inhalation/rabbit	lowest published toxic concentration: 50 mg/m³/8H/35D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555434
inhalation/rat	lowest published toxic concentration: 50 mg/m³/8H/19D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555434
oral/rat	lowest published toxic dose: 783 mg/kg/90D- continuous	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0555434
subcutaneous/mouse	lowest published toxic dose: 125 mg/kg/5D- intermittent	Behavioral: Tetany Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVN5* -,458,1989
subcutaneous/rat	lowest published toxic dose: 100 mg/kg/5D- intermittent	Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal)	VCVN5* -,458,1989
subcutaneous/rat	lowest published toxic dose: 300 mg/kg/15D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVN5* -,458,1989
subcutaneous/rat	lowest published toxic dose: 1144 mg/kg/9W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Endocrine: Changes in adrenal weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 26(10),27,1961

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 52,363,1991
TOXICOLOGY REVIEW		FCTXAV 9,105,1971

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-FINLAND	time-weighted average 0.02 mg(Co)/m³, NOV2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.1 mg(Co)/m³, short term exposure limit 0.4 mg(Co)/m³, SEP2000
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.05 mg(Co)/m³, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDEN	time-weighted average 0.05 mg(Co)/m³, Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 mg(Co)/m³, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.1 mg(Co)/m³, sen, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code A1683; Number of Industries 4; Total Number of Facilities 77; Number of Occupations 12; Total Number of Employees Exposed 3559; Total Number of Female Employees Exposed 1767

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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