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Registry of Toxic Effects of Chemical Substances (RTECS)

Chromium(III) oxide (2:3)

RTECS #

GB6475000

CAS #

1308-38-9

Updated

July 2013

Molecular Weight

152.00

Molecular Formula

Cr2O3

Synonyms

11661 Green
Anhydride chromique (French)
C.I. 77288
C.I. Pigment Green 17
Casalis Green
Chrome Green
Chrome ochre
Chrome Oxide Green BX
Chrome Oxide Green GN-M
Chromia
Chromic Acid Green
Chromic oxide
Chromium oxide (Cr8O12)
Chromium Oxide Green
Chromium Oxide Pigment
Chromium Oxide X1134
Chromium sesquioxide
Chromium(3+) oxide
Dichromium trioxide
Green Chrome Oxide
Green chromic oxide
Green chromium oxide
Green cinnabar
Green Oxide of Chromium
Green oxide of chromium OC-31
Levanox Green GA
OKhP1
P 106F10
PK 5304
Pure Chromium Oxide Green 59

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis10 mmol/LMUREAV 77,109,1980
mutation in mammalian somatic cellslung/hamster50 mg/LMUREAV 169,159,1986
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+enzymatic activation step)DCTODJ 4,185,1981
other mutation test systemslung/hamster100 mg/LMUREAV 169,159,1986
sister chromatid exchangelung/hamster34 mg/LCRNGDP 4,605,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 90 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors		VOONAW 13(11),57,1967
intrapleural/rat lowest published toxic dose: 45 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application		VOONAW 13(11),57,1967
intratracheal/rat lowest published toxic dose: 90 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application		VOONAW 13(11),57,1967

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) lethal dose (50 percent kill): 621 mg/kgTOVEFN (2),18,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 4.2 mg/m3/24H/17W- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVN5* -,303,1989
inhalation/rat lowest published toxic concentration: 150 mg/m3/45D- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		TPKVAL 7,162,1965
inhalation/rat lowest published toxic concentration: 15 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Endocrine: Changes in thyroid weight		TOSCF2 52,278,1999

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 23,205,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 49,49,1990
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEW85DHAX Cr,22,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Cr)/m3DTLVS* 3,35,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Cr)/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 2 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-FRANCEVME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg(Cr)/m3, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Cr)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Cr)/m3, inhal, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Cr)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T0962; Number of Industries 87; Total Number of Facilities 7613; Number of Occupations 56; Total Number of Employees Exposed 88897; Total Number of Female Employees Exposed 11984
National Occupational Hazard Survey 1974Hazard Code M2273; Number of Industries 49; Total Number of Facilities 3141; Number of Occupations 66; Total Number of Employees Exposed 42380
National Occupational Hazard Survey 1974Hazard Code T0962; Number of Industries 7; Total Number of Facilities 288; Number of Occupations 26; Total Number of Employees Exposed 8322

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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