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Registry of Toxic Effects of Chemical Substances (RTECS)

Chromium hydroxide sulfate

RTECS #

GB6240000

CAS #

12336-95-7; 39380-78-4

Updated

July 2013

Molecular Weight

165.07

Molecular Formula

CrHO5S

Synonyms

Basic chromic sulfate
Basic chromium sulfate
Chromedol
Cromo solfato basificato (Spanish)
Monobasic chromium sulfate
Peachrome

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg severeTOVEFN (2)34,1998

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/human500 mg/LBJCAAI 44,219,1981
Cytogenetic Analysisovary/hamster5 mg/LBJCAAI 44,219,1981
DNA inhibitionkidney/hamster500 mg/LBJCAAI 44,219,1981
other mutation test systemskidney/hamster500 mg/LBJCAAI 44,219,1981
other mutation test systemsother cell types/human500 mg/LBJCAAI 44,219,1981
sister chromatid exchangeovary/hamster10 mg/LCRNGDP 6,1327,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
ocular/rabbit lowest published toxic dose: 25 mg/kgEye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects		TOVEFN (2),39,1998
oral/mouse lethal dose (50 percent kill): 2900 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia		TOVEFN (2),39,1998
oral/mouse lethal dose (50 percent kill): 2900 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability		TOVEFN (2),34,1998
oral/rat lethal dose (50 percent kill): 7760 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia		TOVEFN (2),39,1998
oral/rat lethal dose (50 percent kill): 7760 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability		TOVEFN (2),34,1998
oral/woman lowest published lethal dose: 960 mg/kgCardiac: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Necrotic changes		ICMED9 20,145,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 58 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight		NTIS** OTS0557882
inhalation/rat lowest published toxic concentration: 17 mg/m3/6H/5D- intermittentLung, Thorax, or Respiration: Other changesTOSCF2 52,278,1999
oral/rat lowest published toxic dose: 23280 mg/kg/30D- intermittentCardiac: Changes in heart weight

Liver: Liver function tests impaired

Liver: Other changes		TOVEFN (2),39,1998
oral/rat lowest published toxic dose: 23280 mg/kg/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight		TOVEFN (2),39,1998
oral/rat lowest published toxic dose: 23280 mg/kg/30D- intermittentEndocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOVEFN (2),39,1998
oral/rat lowest published toxic dose: 23280 mg/kg/30D- intermittentRelated to Chronic Data: Changes in testicular weightTOVEFN (2),39,1998
oral/rat lowest published toxic dose: 23280 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOVEFN (2),34,1998

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 49,49,1990

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Cr)/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 2 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg(Cr)/m3, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Cr)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 0.02 mg(Cr)/m3, short term exposure limit 0.06 mg(Cr)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Cr)/m3, inhal, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Cr)/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0022; Number of Industries 2; Total Number of Facilities 51; Number of Occupations 4; Total Number of Employees Exposed 1155; Total Number of Female Employees Exposed 51

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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