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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium chloride

RTECS #

DS2625000

CAS #

7787-47-5

Updated

September 201

Molecular Weight

79.91

Molecular Formula

BeCl2

Synonyms

Beryllium dichloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.25%/12HVCVN1* -,97,1988

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis750 µg/discMUREAV 264,163,1991
mutation in mammalian somatic cellslung/hamster2 mmol/LMUREAV 68,259,1979
mutation in microorganisms/Escherichia coli10 µmol/L (-enzymatic activation step)MUREAV 126,9,1984
sister chromatid exchangelung/hamster31 mg/LMUREAV 264,163,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratracheal/rat 1685 µg/kg (3D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities		GISAAA 51(8),44,1986
intratracheal/rat 1685 µg/kg (5D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Other developmental abnormalities		GISAAA 51(8),44,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 µg/m3/1H/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		GTPZAB 19(7),34,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase		VCVN1* -,95,1988
intraperitoneal/guinea pig lethal dose (50 percent kill): 50 mg/kgEQSSDX 1,1,1975
intraperitoneal/mouse lethal dose (50 percent kill): 11987 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 5320 µg/kgFEPRA7 9,264,1950
oral/mouse lethal dose (50 percent kill): 92 mg/kgVCVN1* -,93,1988
oral/rat lethal dose (50 percent kill): 86 mg/kgVCVN1* -,93,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.02 mg(Be)/m3/1H/16W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVN1* -,95,1988
inhalation/rat lowest published toxic concentration: 0.02 mg(Be)/m3/1H/78W- intermittentLung, Thorax, or Respiration: Bronchogenic carcinoma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVN1* -,95,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
TOXICOLOGY REVIEWCTOXAO 6,497,1973
TOXICOLOGY REVIEWMUREAV 533,99,2003
TOXICOLOGY REVIEWHBTME* ,415,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg(Be)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

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