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Registry of Toxic Effects of Chemical Substances (RTECS)

Vanadium pentoxide (dust)

RTECS #

YW2450000

CAS #

1314-62-1

Updated

April 2012

Molecular Weight

181.88

Molecular Formula

O5V2

Synonyms

Anhydride vanadique (French)
C.I. 77938
Divanandium pentoxide
RCRA waste number P120
Vanadic anhydride
Vanadio, pentossido di (Italian)
Vanadium (OSHA)
Vanadium oxide (V2O5)
Vanadium pentaoxide
Vanadium pentoxide
Vanadium pentoxide (ACGIH)
Vanadium, pentoxyde de (French)
Vanadiumpentoxid (German)
Vanadiumpentoxyde (Dutch)
Wanadu pieciotlenek (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderateNTIS** OTS0534556

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageleukocyte/human300 nmol/LMUREAV 359,77,1996
DNA Damagelymphocyte/human30 µmol/LMUREAV 359,77,1996
DNA repair/Bacillus subtilis500 mmol/LMUREAV 77,109,1980
micronucleus testlung/hamster1 mg/LMUREAV 321,35,1994
sex chromosome loss and nondisjunctionlymphocyte/human10 nmol/LMUREAV 386,291,1997

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 10 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
CHYCDW 20,189,1986
intraperitoneal/rat 10 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
HYDXET 24,92,1993
intraperitoneal/rat 50 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
HYDXET 24,202,1993
intraperitoneal/rat 5 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
HYDXET 24,202,1993
intraperitoneal/mouse 179 mg/kg (60D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
56ZJAL 4,423,1996
intraperitoneal/mouse 85 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
MSCREJ 21,711,1993
intraperitoneal/mouse 85 mg/kg (6-15D pregnant)Reproductive: Other effects to embryo or fetusMSCREJ 21,711,1993
intraperitoneal/mouse 170 mg/kg (60D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TCMUD8 16,7,1996
intraperitoneal/mouse 170 mg/kg (60D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TCMUD8 16,7,1996
intravenous/mouse 10900 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemENVRAL 33,47,1984
oral/rat 90 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
CHYCDW 20,189,1986
oral/rat 180 mg/kg (6-15D pregnant)Reproductive: Other effects to embryo or fetusCHYCDW 20,189,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 500 mg/m3/23M30ZIAO -,72,1964
inhalation/human lowest published toxic concentration: 1 mg/m3/8HLung, Thorax, or Respiration: CoughHBTME* -,905,2007
inhalation/human lowest published toxic concentration: 0.1 mg/m3/8HLung, Thorax, or Respiration: SputumHBTME* -,905,2007
inhalation/human lowest published toxic concentration: 10 mg/m3Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
HBTME* -,905,2007
inhalation/human lowest published toxic concentration: 346 mg/m3Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Sputum
AMIHAB 19,497,1959
inhalation/human lowest published toxic concentration: 1 mg/m3/8HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Eye: Conjunctiva irritation
AEHLAU 14,709,1967
inhalation/rat lethal concentration (50 percent kill): 126 mg/m3/6HEye: Other eye effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534556-1
intraperitoneal/mouse lethal dose (50 percent kill): 23 mg/kgTCMUD8 16,7,1996
intraperitoneal/rat lethal dose (50 percent kill): 12 mg/kgATXKA8 16,182,1956
intratracheal/rat lethal dose (50 percent kill): 6 mg/kgBCTKAG 11,191,1978
oral/mouse lethal dose (50 percent kill): 5 mg/kgGISAAA 26(10),6,1961
oral/rat lethal dose (50 percent kill): 10 mg/kgBehavioral: ComaATXKA8 16,182,1956
skin/rabbit lethal dose (50 percent kill): 50 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0534556
subcutaneous/guinea pig lowest published lethal dose: 20 mg/kg30ZIAO -,69,1964
subcutaneous/mouse lethal dose (50 percent kill): 10 mg/kgZVKOA6 19,186,1974
subcutaneous/rat lethal dose (50 percent kill): 14 mg/kgBehavioral: ComaATXKA8 16,182,1956

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3640 gm/m3/1W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
TXAPA9 197,274,2004
inhalation/rat lowest published toxic concentration: 100 µg/m3/24H/24D- continuousBrain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 48(9),77,1983
inhalation/rat lowest published toxic concentration: 2 mg/m3/1H/13W- intermittentBehavioral: Alteration of classical conditioningGISAAA 22(3),25,1957
inhalation/rat lowest published toxic concentration: 60 µg/m3/4H/22W- intermittentLiver: Fatty liver degeneration

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
WDZAEK 4,32,1990
intraperitoneal/rat lowest published toxic dose: 56 mg/kg/14D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 11,119,1982
intraperitoneal/rat lowest published toxic dose: 40 mg/kg/4D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
WDZAEK 4,105,1990
intratracheal/rat lowest published toxic dose: 7200 µg/kg/1Y- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
BCTKAG 11,191,1978
oral/rat lowest published toxic dose: 91 mg/kg/26W- intermittentBehavioral: Alteration of operant conditioningGISAAA 26(10),6,1961
oral/rat lowest published toxic dose: 1280 mg/kg/15W- continuousBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Skin and Appendages: Other: Hair
AMIHBC 8,406,1953

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFRMBAZ 21,325,1973
TOXICOLOGY REVIEW85DHAX V,46,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airceiling concentration 0.5 mg/m3DTLVS* 3,275,1971
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 mg/m3;KZW 0.25 mg/m3, resp, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 0.03 mg(V)/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg(V)/m3, NOV2011
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.5 mg/m3, JAN1999
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.5 mg(V2O5)/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.5 mg(V2O5)/m3, respirable fractionCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.5 mg(V2O5)/m3, respirable dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.5 mg(V2O5)/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-airceiling concentration 0.05 mg/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 76210; Number of Industries 6; Total Number of Facilities 67; Number of Occupations 17; Total Number of Employees Exposed 4468; Total Number of Female Employees Exposed 541
National Occupational Hazard Survey 1974Hazard Code 76210; Number of Industries 7; Total Number of Facilities 333; Number of Occupations 12; Total Number of Employees Exposed 2562

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NIOSH Analytical Method, 1994: Vanadium oxides, 7504
NIOSH Analytical Method, 1996: Elements by ICP, 7300
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-185
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