Registry of Toxic Effects of Chemical Substances (RTECS)
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m-Toluidine
RTECS #
XU2800000CAS #
108-44-1Updated
September 201Molecular Weight
107.17Molecular Formula
C7H9NSynonyms
3-Amino-1-methylbenzene3-Aminophenylmethane
3-Aminotoluen (Czech)
3-Aminotoluene
3-Methylaniline
3-Methylbenzenamine
3-Toluidine
Aniline, 3-methyl-
Benzenamine, 3-methyl- (9CI)
m-Aminotoluene
m-Methylaniline
m-Methylbenzenamine
m-Toluidin (Czech)
m-Toluidine (ACGIH)
m-Toluidyna (Polish)
m-Tolylamine
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 20 mg/24H | moderate | 85JCAE -,459,1986 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,459,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lethal dose (50 percent kill): 116 mg/kg | AISFAR 1,284,1951 | |
| intravenous/cat | lowest published toxic dose: 13.4 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | HPV300 -,-,2001 |
| oral/cat | lethal dose (50 percent kill): >50 mg/kg | NTIS** OTS0573041 | |
| oral/mouse | lethal dose (50 percent kill): 740 mg/kg | HPV300 -,-,2001 | |
| oral/rabbit | lethal dose (50 percent kill): 750 mg/kg | VINIT* #4035-77 | |
| oral/rat | lethal dose (50 percent kill): 450 mg/kg | HPV300 -,-,2001 | |
| oral/wild bird | lethal dose (50 percent kill): 242 mg/kg | AECTCV 12,355,1983 | |
| skin/rabbit | lethal dose (50 percent kill): 3250 mg/kg | NTIS** OTS0573041 | |
| unreported route/rabbit | lethal dose (50 percent kill): 750 mg/kg | HPV300 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 225 mg/kg/3D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV300 -,,2001 |
| oral/mouse | lowest published toxic dose: 218400 mg/kg/13W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV300 -,,2001 |
| oral/rat | lowest published toxic dose: 8400 mg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Proteinuria Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VINIT* #4035-77 |
| oral/rat | lowest published toxic dose: 1722 mg/kg/6W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | IJTOFN 24,365,2005 |
| oral/rat | lowest published toxic dose: 1230 mg/kg/30D- continuous | Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | IJTOFN 24,365,2005 |
| oral/rat | lowest published toxic dose: 8400 mg/kg/30D- continuous | Endocrine: Changes in spleen weight Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV300 -,,2001 |
| oral/rat | lowest published toxic dose: 10920 mg/kg/90D- continuous | Endocrine: Changes in spleen weight Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV300 -,,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ENTOX* -,206,2005 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division