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Registry of Toxic Effects of Chemical Substances (RTECS)

m-Toluidine

RTECS #

XU2800000

CAS #

108-44-1

Updated

September 201

Molecular Weight

107.17

Molecular Formula

C7H9N

Synonyms

3-Amino-1-methylbenzene
3-Aminophenylmethane
3-Aminotoluen (Czech)
3-Aminotoluene
3-Methylaniline
3-Methylbenzenamine
3-Toluidine
Aniline, 3-methyl-
Benzenamine, 3-methyl- (9CI)
m-Aminotoluene
m-Methylaniline
m-Methylbenzenamine
m-Toluidin (Czech)
m-Toluidine (ACGIH)
m-Toluidyna (Polish)
m-Tolylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,459,1986
skin /rabbit 500 mg/24H mild85JCAE -,459,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 116 mg/kgAISFAR 1,284,1951
intravenous/cat lowest published toxic dose: 13.4 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV300 -,-,2001
oral/cat lethal dose (50 percent kill): >50 mg/kgNTIS** OTS0573041
oral/mouse lethal dose (50 percent kill): 740 mg/kgHPV300 -,-,2001
oral/rabbit lethal dose (50 percent kill): 750 mg/kgVINIT* #4035-77
oral/rat lethal dose (50 percent kill): 450 mg/kgHPV300 -,-,2001
oral/wild bird lethal dose (50 percent kill): 242 mg/kgAECTCV 12,355,1983
skin/rabbit lethal dose (50 percent kill): 3250 mg/kgNTIS** OTS0573041
unreported route/rabbit lethal dose (50 percent kill): 750 mg/kgHPV300 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 225 mg/kg/3D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV300 -,,2001
oral/mouse lowest published toxic dose: 218400 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV300 -,,2001
oral/rat lowest published toxic dose: 8400 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VINIT* #4035-77
oral/rat lowest published toxic dose: 1722 mg/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainIJTOFN 24,365,2005
oral/rat lowest published toxic dose: 1230 mg/kg/30D- continuousLiver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJTOFN 24,365,2005
oral/rat lowest published toxic dose: 8400 mg/kg/30D- continuousEndocrine: Changes in spleen weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV300 -,,2001
oral/rat lowest published toxic dose: 10920 mg/kg/90D- continuousEndocrine: Changes in spleen weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV300 -,,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,206,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (8.8 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (9 mg/m3);KZW 4 ppm (18 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (8.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (9 mg/m3), skin, MAY2011
Occupational Exposure Limit-HUNGARYtime-weighted average 9 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (9 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (9 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (8.8 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (8,8 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (9 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 9 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 81889; Number of Industries 3; Total Number of Facilities 257; Number of Occupations 3; Total Number of Employees Exposed 2876

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73
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