Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, m-nitro-

RTECS #

XT2975000

CAS #

99-08-1

Updated

September 201

Molecular Weight

137.15

Molecular Formula

C₇H₇NO₂

Synonyms

1-Methyl-3-nitrobenzene
3-Methylnitrobenzene
3-Nitrotoluene
3-Nitrotoluol
Benzene, 1-methyl-3-nitro- (9CI)
meta-Nitrotoluol
m-Methylnitrobenzene
m-Nitrotoluene
m-Nitrotoluene (ACGIH:OSHA)
MNT
Nitrotoluene, meto-

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	580 mg/24H	mild	HPV285 -,-,2001

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
micronucleus test	lung/hamster	2500 µmol/L/6H (+enzymatic activation step)	MUTAEX 26,709,2011
micronucleus test	lung/hamster	5000 µmol/L/48H (-enzymatic activation step)	MUTAEX 26,709,2011
sister chromatid exchange	ovary/hamster	115 mg/L	EMMUEG 10(Suppl 10),1,1987

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	31122 mg/kg (13W prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders	NTPTR* NIH-93-3346
oral/rat	60151 mg/kg (13W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	NTPTR* NIH-93-3346

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 425 mg/m³	Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia	GTPZAB 22(7),52,1978
inhalation/mouse	lethal concentration (50 percent kill): >157 ppm/4H		HPV285 -,-,2001
inhalation/mouse	lethal concentration (50 percent kill): >2417 mg/m³/1H		HPV285 -,-,2001
inhalation/rat	lethal concentration (50 percent kill): >157 ppm/4H		HPV285 -,-,2001
inhalation/rat	lethal concentration (50 percent kill): >2417 mg/m³/1H		HPV285 -,-,2001
inhalation/rat	lethal concentration (50 percent kill): 693 mg/m³	Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia	GTPZAB 22(7),52,1978
oral/guinea pig	lethal dose (50 percent kill): 3600 mg/kg		CHABA8 73,91015e,1970
oral/mouse	lethal dose (50 percent kill): 330 mg/kg		CHABA8 73,91015e,1970
oral/rabbit	lethal dose (50 percent kill): 1750 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Liver: Fatty liver degeneration Blood: Methemoglobinemia- Carboxhemoglobinemia	GTPZAB 22(7),52,1978
oral/rat	lethal dose (50 percent kill): 1070 mg/kg		HPV285 -,-,2001
skin/rabbit	lethal dose (50 percent kill): >20000 mg/kg		HPV285 -,-,2001
skin/rat	lethal dose (50 percent kill): >1157 mg/kg		HPV285 -,-,2001
unreported route/guinea pig	lethal dose (50 percent kill): 3600 mg/kg		HPV285 -,-,2001
unreported route/mouse	lethal dose (50 percent kill): 330 mg/kg		HPV285 -,-,2001
unreported route/rabbit	lethal dose (50 percent kill): 1750 mg/kg		HPV285 -,-,2001
unreported route/rat	lethal dose (50 percent kill): 1590 mg/kg		HPV285 -,-,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 30 mg/m³/4H/17W- intermittent	Kidney, Ureter, and Bladder: Proteinuria Kidney, Ureter, and Bladder: Other changes in urine composition	GTPZAB 22(7),52,1978
oral/mouse	lowest published toxic dose: 9191 mg/kg/13W- intermittent	Liver: Changes in liver weight	HPV285 -,-,2001
oral/mouse	lowest published toxic dose: 68250 mg/kg/13W- intermittent	Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV285 -,-,2001
oral/mouse	lowest published toxic dose: 136500 mg/kg/13W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV285 -,-,2001
oral/mouse	lowest published toxic dose: 67613 mg/kg/13W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Changes in testicular weight	NTPTR* NIH-93-3346
oral/mouse	lowest published toxic dose: 5600 mg/kg/14D- intermittent	Endocrine: Changes in thymus weight Blood: Changes in other cell count (unspecified)	DCTODJ 17,359,1994
oral/rat	lowest published toxic dose: 31122 mg/kg/13W- continuous	Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in platelet count Related to Chronic Data: Changes in testicular weight	NTPTR* NIH-93-3346
oral/rat	lowest published toxic dose: 10000 mg/kg/4W- intermittent	Lung, Thorax, or Respiration: Dyspnea	HPV285 -,-,2001
oral/rat	lowest published toxic dose: 20000 mg/kg/4W- intermittent	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV285 -,-,2001
oral/rat	lowest published toxic dose: 36000 mg/kg/24W- intermittent	Blood: Other changes Skin and Appendages: Other: Hair	HPV285 -,-,2001
oral/rat	lowest published toxic dose: 4277 mg/kg/13W- intermittent	Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	HPV285 -,-,2001
oral/rat	lowest published toxic dose: 17108 mg/kg/13W- intermittent	Kidney, Ureter, and Bladder: Changes primarily in glomeruli Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	HPV285 -,-,2001
oral/rat	lowest published toxic dose: 68250 mg/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes primarily in glomeruli Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	HPV285 -,-,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (skin)	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 65,409,1996
TOXICOLOGY REVIEW		MUTAEX 23,271,2008

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (11 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (11 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (12 mg/m³), skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (11 mg/m³), Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (12 mg/m³), skin, NOV2011
Occupational Exposure Limit-MEXICO	time-weighted average 5 ppm (30 mg/m³);short term exposure limit 10 ppm (60 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 2 ppm (11 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (5.5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (11 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 3 mg/m³, MAC(short term exposure limit) 9 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (6 mg/m³);short term exposure limit 2 ppm (11 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (11 mg/m³), KZG-week 4 ppm (22 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 6 mg/m³, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 ppm (30 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 ppm (30 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 ppm (30 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 ppm (30 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-NITROTOLUENE-air	10H time-weighted average 2 ppm (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-23, October 2000

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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