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Registry of Toxic Effects of Chemical Substances (RTECS)

Thiopyrophosphoric acid, tetraethyl ester

RTECS #

XN4375000

CAS #

3689-24-5

Updated

December 2013

Molecular Weight

322.34

Molecular Formula

C8H20O5P2S2

Synonyms

ASP 47
BAY-E-393
Bayer-E 393
Bis-O,O-diethylphosphorothionic anhydride
Bladafum
Di(thiophosphoric) acid, tetraethyl ester
Dithiodiphosphoric acid, tetraethyl ester
Dithiofos
Dithiophos
Dithiopyrophosphate de tetraethyle (French)
Dithiotep
E393
ENT 16,273
Ethyl thiopyrophosphate ((EtO)2(PS)2O)
Lethalaire G-57
O,O,O,O-Tetraaethyl-dithionopyrophosphat (German)
O,O,O,O-Tetraethyl dithiopyrophosphate
O,O,O,O-Tetraethyl-dithio-difosfaat (Dutch)
O,O,O,O-Tetraetil-ditio-pirofosfato (Italian)
Plantfume 103 smoke generator
Pyrophosphorodithioic acid, O,O,O,O-tetraethyl ester
Pyrophosphorodithioic acid, tetraethyl ester
RCRA waste number P109
Sulfotep
Sulfotep (ACGIH:OSHA)
Sulfotepp
TEDP (OSHA)
TEDTP
Tetraethyl dithionopyrophosphate
Tetraethyl dithiopyrophosphate
Tetraethyldithiodifosfat (Czech)
Thiodiphosphoric acid tetraethyl ester
Thiotepp

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)EMMUEG 11(Suppl 12),1,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 40 mg/m3/4HAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
inhalation/rat lethal concentration (50 percent kill): 38 mg/m3/4HAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
intramuscular/mouse lethal dose (50 percent kill): 500 µg/kgCJCHAG 34,1819,1956
intramuscular/rat lethal dose (50 percent kill): 55 µg/kgCJCHAG 34,1819,1956
intraperitoneal/chicken lethal dose (50 percent kill): 25 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		ARTODN 33,1,1974
intraperitoneal/mouse lethal dose (50 percent kill): 940 µg/kgCJCHAG 34,1819,1956
intraperitoneal/rat lethal dose (50 percent kill): 6600 µg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
intravenous/mouse lethal dose (50 percent kill): 300 µg/kgCJCHAG 34,1819,1956
oral/cat lethal dose (50 percent kill): 3 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
oral/chicken lethal dose (50 percent kill): 25 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		ARTODN 33,1,1974
oral/Dog lethal dose (50 percent kill): 5 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
oral/mouse lethal dose (50 percent kill): 22 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
oral/rabbit lethal dose (50 percent kill): 25 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
oral/rat lethal dose (50 percent kill): 5 mg/kgARSIM* 20,24,1966
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): 20 mg/kgWRPCA2 9,119,1970
skin/rat lethal dose (50 percent kill): 65 mg/kgAutonomic Nervous System: Other (direct) parasympathomimeticARTODN 33,1,1974
subcutaneous/mouse lethal dose (50 percent kill): 8 mg/kgPAREAQ 11,636,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2830 µg/m3/6H/12W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		ARTODN 33,1,1974
oral/rat lowest published toxic dose: 91 mg/kg/13W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		ARTODN 33,1,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMUREAV 726,91,2011
TOXICOLOGY REVIEWMUREAV 746,89,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,149,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg/m3DTLVS* 3,244,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.007 ppm (0.1 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.0075 ppm (0.1 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.008 ppm (0.1 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.1 mg/m3, skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.01 ppm (0.13 mg/m3), skin, 2011
Occupational Exposure Limit-GERMANYMAK 0.01 ppm (0.13 mg/m3), skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.015 ppm (0.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.015 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.0075 ppm (0.1 mg/m3), KZG-week 0.015 ppm (0.2 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEDP-air10H time-weighted average 0.2 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 82116; Number of Industries 5; Total Number of Facilities 674; Number of Occupations 8; Total Number of Employees Exposed 8085; Total Number of Female Employees Exposed 27

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8874
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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