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Registry of Toxic Effects of Chemical Substances (RTECS)

Sulfuric acid

RTECS #

WS5600000

CAS #

7664-93-9; 119540-51-1; 127529-01-5

Updated

September 201

Molecular Weight

98.08

Molecular Formula

H2O4S

Synonyms

Acide sulfurique (French)
Acido solforico (Italian)
Battery acid
BOV
Dihydrogen sulfate
Dipping acid
Electrolyte acid
Mattling acid
Oil of vitriol
Schwefelsaeureloesungen (German)
Strong inorganic acid mists containing sulfuric acid
Sulfuric acid (ACGIH:OSHA)
Sulfuric acid, aerosol
Sulphuric acid
Vitriol Brown Oil
Zwavelzuuroplossingen (Dutch)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946
eye /rabbit 5 mg/30S rinse severeTXCYAC 23,281,1982

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster4 mmol/LMUREAV 225,55,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 20 mg/m3/7H (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJEHSDH 13,251,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 20 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/cat Lowest published lethal concentration: 461 mg/m3/7HVCVN5* -,239,1993
inhalation/guinea pig lethal concentration (50 percent kill): 18 mg/m3/8HVCVN5* -,239,1993
inhalation/guinea pig lowest published toxic concentration: 8 mg/m3/5DBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVN5* -,240,1993
inhalation/guinea pig lethal concentration (50 percent kill): 18 mg/m3Lung, Thorax, or Respiration: Other changesMELAAD 45,590,1954
inhalation/guinea pig Lowest published lethal concentration: 65 mg/m3/30MLung, Thorax, or Respiration: Bronchiolar constriction, including asthmaVCVN5* -,239,1993
inhalation/human lowest published toxic concentration: 3 mg/m3/24WMusculoskeletal: Changes in teeth and supporting structuresBJIMAG 18,63,1961
inhalation/human lowest published toxic concentration: 1 mg/m3/3HLung, Thorax, or Respiration: Other changesINHTE5 9,731,1997
inhalation/human lowest published toxic concentration: 0.6 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,241,1993
inhalation/human lowest published toxic concentration: 0.73 mg/m3Eye: Other eye effectsVCVN5* -,241,1993
inhalation/human lowest published toxic concentration: 0.63 mg/m3Brain and Coverings: Changes in surface EEGVCVN5* -,241,1993
inhalation/human lowest published toxic concentration: 3 mg/m3/5MLung, Thorax, or Respiration: DyspneaVCVN5* -,241,1993
inhalation/mouse lethal concentration (50 percent kill): 320 mg/m3/2H85GMAT -,107,1982
inhalation/mouse Lowest published lethal concentration: 461 mg/m3/7HVCVN5* -,239,1993
inhalation/mouse lethal concentration (50 percent kill): 320 mg/m3VCVN5* -,239,1993
inhalation/rabbit Lowest published lethal concentration: 461 mg/m3/7HVCVN5* -,239,1993
inhalation/rat lethal concentration (50 percent kill): 510 mg/m3VCVN5* -,239,1993
inhalation/rat Lowest published lethal concentration: 461 mg/m3/7HVCVN5* -,239,1993
inhalation/rat lethal concentration (50 percent kill): 510 mg/m3/2H85GMAT -,107,1982
oral/rat lethal dose (50 percent kill): 2140 mg/kgFEREAC 69,40781,2004
unreported route/man lowest published lethal dose: 135 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 900 µg/m3/21H/89W- intermittentCardiac: Changes in heart weight

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight		AEHLAU 26,16,1973
inhalation/Dog lowest published toxic concentration: 0.9 mg/m3/21H/620D- intermittentLung, Thorax, or Respiration: Respiratory depressionVCVN5* -,244,1989
inhalation/guinea pig lowest published toxic concentration: 30 mg/m3/7D- continuousLung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JTEHD6 3,521,1977
inhalation/guinea pig lowest published toxic concentration: 4 mg/m3/24H/18D- continuousLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVN5* -,243,1989
inhalation/horse, donkey lowest published toxic concentration: 0.1 mg/m3/5D/26W- intermittentLung, Thorax, or Respiration: Other changesVCVN5* -,244,1989
inhalation/monkey lowest published toxic concentration: 2.4 mg/m3/24H/78W- continuousLung, Thorax, or Respiration: Other changesVCVN5* -,243,1989
inhalation/monkey lowest published toxic concentration: 2 mg/m3/23H/78W- intermittentLung, Thorax, or Respiration: Other changesAEHLAU 27,16,1973
inhalation/monkey lowest published toxic concentration: 2.4 mg/m3/24H/78W- continuousLung, Thorax, or Respiration: Respiratory depressionVCVN5* -,244,1989
inhalation/rat lowest published toxic concentration: 0.3 mg/m3/6H/5D- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes		JAPTO* 22,387,2002
inhalation/rat lowest published toxic concentration: 0.2 mg/m3/6H/4W- intermittentLung, Thorax, or Respiration: Other changesJAPTO* 22,387,2002
inhalation/rat lowest published toxic concentration: 1.8 mg/m3/24H/65D- continuousPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli		VCVN5* -,243,1989
inhalation/rat lowest published toxic concentration: 784 µg/m3/24H/84D- continuousBehavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 38(3),6,1973

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3 (thoracic)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 54,41,1992
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 54,41,1992
TOXICOLOGY REVIEWEVHPAZ 10,35,1975
TOXICOLOGY REVIEWARTODN 39,299,1978
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWCHHSA* 10,40,2003
TOXICOLOGY REVIEWDIMON* 46,551,2000
TOXICOLOGY REVIEWENTOX* -,117,2005
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWHUTOX* -,671,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,325,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg/m3DTLVS* 3,239,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 mg/m3;KZW 2 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 mg/m3, short term exposure limit 0.1 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, VLE 3 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 1 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-JAPANceiling concentration 1 mg/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3; short term exposure limit 3 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 1 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULFURIC ACID-air10H time-weighted average 1 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 70870; Number of Industries 300; Total Number of Facilities 54516; Number of Occupations 182; Total Number of Employees Exposed 775587; Total Number of Female Employees Exposed 173653
National Occupational Hazard Survey 1974Hazard Code 70870; Number of Industries 313; Total Number of Facilities 54746; Number of Occupations 143; Total Number of Employees Exposed 499446

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/122038)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9247;8EHQ-0892-9248
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-113

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