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Registry of Toxic Effects of Chemical Substances (RTECS)

Stannane, tricyclohexylhydroxy-

RTECS #

WH8750000

CAS #

13121-70-5

Updated

September 201

Molecular Weight

385.21

Molecular Formula

C18H34OSn

Synonyms

Cyhexatin
Cyhexatin (ACGIH)
Dowco-213
ENT 27,395-X
ENT 27395
M 3180
Plictran
Plictran 50W
Plyctran
TCTH
Tin, tricyclohexylhydroxy-
Tricyclohexylhydroxystannane
Tricyclohexylhydroxytin
Tricyclohexylstannanol
Tricyclohexylstannium hydroxide
Tricyclohexyltin hydroxide
Tricyclohexylzinnhydroxid (German)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human25 mg/LMUREAV 321,219,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 108 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EQSFAP 4,80,1975
oral/rabbit 23.25 mg/kg (1-31D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)		HBPTO* 2,1217,2001
skin/rabbit 3 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)HBPTO* 2,1217,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 290 mg/m3GTPZAB 28(5),52,1984
inhalation/rat lethal concentration (50 percent kill): 244 mg/m3GISAAA 49(2),74,1984
intraperitoneal/rat lethal dose (50 percent kill): 13 mg/kgDOWCC*
oral/cat lethal dose (50 percent kill): >800 mg/kgGastrointestinal: Nausea or vomitingEQSFAP 4,80,1975
oral/chicken lethal dose (50 percent kill): 654 mg/kgHBPTO* 2,1216,2001
oral/Dog lethal dose (50 percent kill): >800 mg/kgGastrointestinal: Nausea or vomitingEQSFAP 4,80,1975
oral/domestic animal lowest published lethal dose: 150 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Fluid intake		TXAPA9 31,66,1975
oral/guinea pig lethal dose (50 percent kill): 780 mg/kgHBPTO* 2,1216,2001
oral/monkey lethal dose (50 percent kill): >800 mg/kgGastrointestinal: Nausea or vomitingEQSFAP 4,80,1975
oral/mouse lethal dose (50 percent kill): 275 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve		GISAAA 47(7),80,1982
oral/quail lethal dose (50 percent kill): 255 mg/kgEQSFAP 4,80,1975
oral/rabbit lethal dose (50 percent kill): 458 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve		GISAAA 47(7),80,1982
oral/rat lethal dose (50 percent kill): 180 mg/kgKSKZAN 16(2),59,1978
oral/rat lowest published toxic dose: 50 mg/kgBehavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea		HBPTO* 2,1216,2001
skin/human lowest published toxic dose: 11 µg/kg/1DNutritional and Gross Metabolic: Changes in: Other metalsHBPTO* 2,1218,2001
skin/rabbit lethal dose (50 percent kill): 2422 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve		GISAAA 47(7),80,1982
skin/rat lethal dose (50 percent kill): 446 mg/kgFAATDF 7,299,1986
subcutaneous/mammal (species unspecified) lowest published toxic dose: 30 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		HBTME* -,839,2007
unreported route/mouse lethal dose (50 percent kill): 780 mg/kgTGANAK 16(1),45,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 270 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainEQSFAP 4,80,1975
oral/mammal (species unspecified) lowest published toxic dose: 2310 mg/kg/44W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		GISAAA 47(7),80,1982
oral/mouse lowest published toxic dose: 1201 mg/kg/4D- continuousEndocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		PCBPBS 6,270,1976
oral/mouse lowest published toxic dose: 8640 mg/kg/90D- continuousBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		EQSFAP 4,80,1975
oral/rat lowest published toxic dose: 180 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		GISAAA 49(2),74,1984
oral/rat lowest published toxic dose: 2700 mg/kg/90D- continuousBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		EQSFAP 4,80,1975
oral/rat lowest published toxic dose: 2190 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1217,2001
oral/rat lowest published toxic dose: 730 mg/kg/2Y- continuousLiver: Other changesHBPTO* 2,1217,2001
oral/rat lowest published toxic dose: 4380 mg/kg/2Y- continuousSpinal Cord: Other degenerative changesHBPTO* 2,1217,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Sn)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 0.2 mg(Sn)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEQSFAP 4,80,1975
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,106,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.02 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Sn)/m3, KZG-week 0.2 mg(Sn)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Sn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYHEXATIN-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air10H time-weighted average 0.1 mg(Sn)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organotin compounds as Sn, 5504

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