Registry of Toxic Effects of Chemical Substances (RTECS)
ShareCompartir
Silicic acid, tetraethyl ester
RTECS #
VV9450000CAS #
78-10-4Updated
September 201Molecular Weight
208.37Molecular Formula
C8H20O4SiSynonyms
Ethyl orthosilicateEthyl silicate
Ethyl silicate (ACGIH:OSHA)
Etylu krzemian (Polish)
Silane, tetraethoxy-
Silicate d'ethyle (French)
Silicate tetraethylique (French)
TEOS
Tetraethoxysilane
Tetraethyl orthosilicate
Tetraethylsilikat (Czech)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /guinea pig | 2500 ppm/2H | severe | JIHTAB 22,288,1940 |
| eye /human | 3000 ppm | JIHTAB 22,288,1940 | |
| eye /rabbit | 100 mg | mild | UCDS** 7/23/1970 |
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,1231,1986 |
| skin /rabbit | 500 mg/24H | moderate | UCDS** 7/23/1970 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: >5.9 gm/m3/3H | Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands | TPKVAL 5,192,1963 |
| inhalation/guinea pig | Lowest published lethal concentration: 700 ppm/6H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Interstitial nephritis | JIHTAB 22,288,1940 |
| inhalation/guinea pig | Lowest published lethal concentration: 10 gm/m3/3H | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Eye: Corneal damage Behavioral: Tremor | TPKVAL 5,192,1963 |
| inhalation/guinea pig | Lowest published lethal concentration: 21 gm/m3/2H | Brain and Coverings: Changes in circulation Behavioral: Ataxia Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 5,192,1963 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 3.2 gm/m3 | TPKVAL 3,81,1961 | |
| inhalation/mammal (species unspecified) | Lowest published lethal concentration: 4500 mg/m3 | Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Fatty liver degeneration Blood: Other changes | TPKVAL 3,81,1961 |
| inhalation/mammal (species unspecified) | Lowest published lethal concentration: 4.5 gm/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TPKVAL 3,81,1961 |
| inhalation/mouse | Lowest published lethal concentration: 1 gm/m3/2H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 5,192,1963 |
| inhalation/mouse | Lowest published lethal concentration: 50 gm/m3/2H | Behavioral: Toxic psychosis Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis | TPKVAL 3,18,1961 |
| inhalation/mouse | Lowest published lethal concentration: 10 gm/m3/2H | Brain and Coverings: Changes in circulation Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) | TPKVAL 3,18,1961 |
| inhalation/mouse | Lowest published lethal concentration: 30 gm/m3/2H | Liver: Other changes Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney Blood: Changes in spleen | TPKVAL 3,18,1961 |
| inhalation/mouse | Lowest published lethal concentration: 20 gm/m3/2H | Cardiac: Other changes Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Respiratory obstruction | TPKVAL 3,18,1961 |
| inhalation/mouse | Lowest published lethal concentration: 60 gm/m3 | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: Somnolence (general depressed activity) Behavioral: Tremor | TPKVAL 5,192,1963 |
| inhalation/mouse | lethal concentration (50 percent kill): 30 gm/m3 | Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands | TPKVAL 5,192,1963 |
| inhalation/mouse | Lowest published lethal concentration: 20 gm/m3 | Kidney, Ureter, and Bladder: Interstitial nephritis Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | TPKVAL 5,192,1963 |
| inhalation/rat | lowest published toxic concentration: >5.9 gm/m3/3H | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: Somnolence (general depressed activity) Behavioral: Tremor | TPKVAL 5,192,1963 |
| inhalation/rat | Lowest published lethal concentration: 10 gm/m3/3H | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Eye: Corneal damage Behavioral: Tremor | TPKVAL 5,192,1963 |
| inhalation/rat | Lowest published lethal concentration: 1000 ppm/4H | JIHTAB 31,343,1949 | |
| inhalation/rat | Lowest published lethal concentration: 21 gm/m3/2H | Brain and Coverings: Changes in circulation Behavioral: Ataxia Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 5,192,1963 |
| inhalation/rat | Lowest published lethal concentration: 9 gm/m3/4H | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Normocytic anemia | TPKVAL 3,10,1961 |
| inhalation/rat | lowest published toxic concentration: 21 gm/m3/2H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Dyspnea | TPKVAL 3,10,1961 |
| inhalation/rat | Lowest published lethal concentration: 21 gm/m3/3H | Vascular: Other changes Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Acute pulmonary edema | TPKVAL 3,10,1961 |
| inhalation/rat | Lowest published lethal concentration: 1 gm/m3/2H | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Hemorrhage | TPKVAL 5,192,1963 |
| intraperitoneal/mouse | lowest published lethal dose: 830 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NEZAAQ 46,231,1991 |
| intraperitoneal/rat | lowest published lethal dose: 0.6 mL/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Acute pulmonary edema | TPKVAL 3,10,1961 |
| intravenous/rabbit | lowest published lethal dose: 0.02 mL/kg | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: General anesthetic Behavioral: Tremor | TPKVAL 3,10,1961 |
| intravenous/rabbit | lowest published lethal dose: 400 mg/kg | Lung, Thorax, or Respiration: Pleural effusion Kidney, Ureter, and Bladder: Interstitial nephritis Blood: Other hemolysis with or without anemia | INMEAF 6,660,1937 |
| intravenous/rabbit | lowest published lethal dose: 0.2 mL/kg | Lung, Thorax, or Respiration: Other changes Vascular: Structural changes in vessels Blood: Hemorrhage | INMEAF 6,660,1937 |
| intravenous/rat | lowest published lethal dose: 0.6 mL/kg | Lung, Thorax, or Respiration: Other changes Vascular: Structural changes in vessels Blood: Hemorrhage | INMEAF 6,660,1937 |
| oral/rat | lowest published toxic dose: 0.555 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Kidney, Ureter, and Bladder: Other changes | FAATDF 18,425,1992 |
| oral/rat | lowest published lethal dose: 2800 mg/kg | Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 18,425,1992 |
| oral/rat | lethal dose (50 percent kill): 6270 mg/kg | JIHTAB 31,60,1949 | |
| oral/rat | lowest published lethal dose: 1000 mg/kg | Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 3,10,1961 |
| skin/rabbit | lethal dose (50 percent kill): 6300 µL/kg | UCDS** 7/23/1970 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 200 ppm/6H/4W- intermittent | Olfaction: Other olfaction effects Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 68,277,1994 |
| inhalation/mouse | lowest published toxic concentration: 200 ppm/6H/2W- intermittent | Olfaction: Other olfaction effects Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NEZAAQ 46,232,1991 |
| inhalation/rat | lowest published toxic concentration: 1.5 gm/m3/17D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 3,10,1961 |
| inhalation/rat | lowest published toxic concentration: 32 gm/m3/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 3,10,1961 |
| inhalation/rat | lowest published toxic concentration: 0.2 gm/m3/61D- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Liver: Liver function tests impaired | TPKVAL 5,192,1963 |
| inhalation/rat | lowest published toxic concentration: 0.2 gm/m3/153D- intermittent | Brain and Coverings: Other degenerative changes Cardiac: Changes in coronary arteries Blood: Changes in spleen | TPKVAL 5,192,1963 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/7H/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Hematuria Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 30,332,1948 |
| oral/rat | lowest published toxic dose: 1.11 mg/kg/2D- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Kidney, Ureter, and Bladder: Other changes | FAATDF 18,425,1992 |
| oral/rat | lowest published toxic dose: 2.22 mg/kg/4D- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Kidney, Ureter, and Bladder: Other changes | FAATDF 18,425,1992 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (850 mg/m3) | DTLVS* 3,108,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (85 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 20 ppm (170 mg/m3);KZW 40 ppm (340 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (86 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (85 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (24 mg/m3), short term exposure limit 10 ppm (48 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 ppm (85 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 10 ppm (86 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (85 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 10 ppm (85 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (85 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (85 mg/m3);short term exposure limit 30 ppm (255 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (85 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (85 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 ppm (85 mg/m3); short term exposure limit 30 ppm (256 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 80 mg/m3, MAC(short term exposure limit) 250 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 20 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 10 ppm (85 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 85 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (850 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (850 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (850 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (850 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (850 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (850 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL SILICATE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X4097; Number of Industries 22; Total Number of Facilities 721; Number of Occupations 26; Total Number of Employees Exposed 10422; Total Number of Female Employees Exposed 2566 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division