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Registry of Toxic Effects of Chemical Substances (RTECS)

Silica, crystalline - quartz

RTECS #

VV7330000

CAS #

14808-60-7; 1317-79-9

Updated

September 201

Molecular Weight

60.09

Molecular Formula

O2Si

Synonyms

Agate
alpha-Quartz
Amethyst
Chalcedony
Cherts
Crystalline silica
Crystallized silicon dioxide
D & D
DQ12
Flint
Flintshot
Gold bond R
Imsil
Min-U-Sil
Novaculite
Onyx
Quartz
Quartz silica
Quazo puro (Italian)
Rock crystal
Rose quartz
Sand
SF 35
Sicron F 300
Siderite (SiO2)
Sikron F 100
Sil-Co-Sil
Silica
Silica dust
Silica flour (powdered crystalline silica)
Silica, crystalline quartz (ACGIH:OSHA)
Silicon oxide, di- (sand)
Silver bond B
Snowit
TGL 16319
Tiger-eye
W 12
W 12 (Filler)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintratracheal/rat3 mg/kgTXAPA9 189,84,2003
DNA Damageother cell types/human120 mg/L/24HEMMUEG 48,151,2007
DNA Damageother cell types/human120 mg/LEMMUEG 48,151,2007
DNA Damagelung/rat500 mg/plate/4HMUREAV 617,46,2007
micronucleus testlung/human40 µg/cm2MUREAV 335,27,1995
micronucleus testlung/hamster160 µg/cm2MUREAV 335,27,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 4000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		BJCAAI 22,825,1968
implant/rat toxic dose: 4554 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		CORTBR 88,223,1972
implant/rat lowest published toxic dose: 900 mg/kgTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application		AICCA6 10,119,1954
inhalation/rat lowest published toxic concentration: 50 mg/m3/6H/71W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		ENVRAL 40,499,1986
intraperitoneal/rat lowest published toxic dose: 45 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application		ZHPMAT 162,467,1976
intraperitoneal/rat toxic dose: 90 mg/kg/4W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		JNCIAM 57,509,1976
intraperitoneal/rat toxic dose: 450 mg/kg/4W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors		NATWAY 59,318,1972
intrapleural/hamster lowest published toxic dose: 83 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		31BYAP -,92,1974
intrapleural/rat lowest published toxic dose: 90 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		JNCIAM 57,509,1976
intrapleural/rat toxic dose: 200 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma		JNCIAM 48,797,1972
intrapleural/rat toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Lung, Thorax, or Respiration: Tumors		BJCAAI 41,908,1980
intrapleural/rat toxic dose: 100 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Tumors		AIHAAP 41,836,1980
intrapleural/rat toxic dose: 100 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		JJIND8 79,797,1987
intratracheal/rat lowest published toxic dose: 111 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		CREMEX 2,243,1986
intratracheal/rat lowest published toxic dose: 100 mg/kg/19W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		EVHPAZ 34,47,1980
intravenous/rat lowest published toxic dose: 90 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		JNCIAM 57,509,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
implant/rabbit lowest published toxic dose: 20 mg/kgLung, Thorax, or Respiration: Fibrosing alveolitis

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXAPA9 183,46,2002
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 125 mg/L/17HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 1,71,1987
In Vitro/Human, erythrocytes Inhibitor Concentration (50 percent kill): 2.86 gm/L/2HIn Vitro Toxicity Studies: Hemolysis in vitroTIVIEQ 1,239,1987
In Vitro/Human, kidney Inhibitor Concentration (50 percent kill): 36.19 mg/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 272,11,2010
In Vitro/Human, kidney Inhibitor Concentration Low: 10 mg/L/48HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 272,11,2010
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 68 mg/L/17HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 1,77,1987
inhalation/human lowest published toxic concentration: 16 million particles per cubic foot/8H/17.9Y- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		NTIS** PB246-697
inhalation/human Lowest published lethal concentration: 300 µg/m3/10Y- intermittentLiver: Other changesANYAA9 271,324,1976
inhalation/mouse lowest published toxic concentration: 40 mg/kgLung, Thorax, or Respiration: Other changesTOXID9 72,45,2003
inhalation/mouse lowest published toxic concentration: 40 mg/kgImmunological Including Allergic: Decrease in cellular immune responseTOXID9 72(Suppl 1),372,2003
inhalation/rat lowest published toxic concentration: 248 mg/m3/6HLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,306,2008
inhalation/rat lowest published toxic concentration: 1 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 44,213,2005
inhalation/rat lowest published toxic concentration: 200 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Changes in: Fe		AJPHAP 267,L686,1994
inhalation/rat lowest published toxic concentration: 248 mg/m3/6HLung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 266,16,2009
intratracheal/mouse lowest published toxic dose: 80 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXAPA9 185,1,2002
intratracheal/mouse Lethal dose: >20 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		ARDSBL 141(Suppl),A3-A937,1990
intratracheal/mouse lowest published toxic dose: 16.7 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaTOXID9 72,44,2003
intratracheal/mouse lowest published toxic dose: 1 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,390,2009
intratracheal/mouse lowest published toxic dose: 100 mg/kgTumorigenic: Increased incidence of tumors in susceptible strainsTOLED5 142,71,2003
intratracheal/mouse lowest published toxic dose: 100 mg/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Acute pulmonary edema		TOXID9 60,423,2001
intratracheal/rat lowest published toxic dose: 1 mg/kgTOXID9 90,214,2006
intratracheal/rat lowest published toxic dose: 1 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 225,119,2006
intratracheal/rat lowest published toxic dose: 150 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		TOLED5 158,1,2005
intratracheal/rat lowest published toxic dose: 10 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		TXAPA9 194,111,2004
intratracheal/rat lowest published toxic dose: 1250 µg/kgLung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOLED5 149,255,2004
intratracheal/rat lowest published toxic dose: 100 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOLED5 155,353,2005
intratracheal/rat lowest published toxic dose: 30 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes		TOXID9 66,76,2002
intratracheal/rat lowest published toxic dose: 50 mg/kgLung, Thorax, or Respiration: Other changesTOXID9 66,98,2002
intratracheal/rat lowest published toxic dose: 10 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increased immune response		TOXID9 78,191,2004
intratracheal/rat lowest published toxic dose: 5 mg/kgLung, Thorax, or Respiration: Consolidation

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 78,382,2004
intratracheal/rat lowest published toxic dose: 15.69 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes		TOXID9 72,43,2003
intratracheal/rat lowest published toxic dose: 150 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		TOXID9 72(Suppl 1),372,2003
intratracheal/rat lowest published toxic dose: 25 mg/kgLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Other changes		TOXID9 72,45,2003
intratracheal/rat lowest published lethal dose: 250 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes		JTEHD6 19,403,1986
intratracheal/rat lowest published toxic dose: 240 mg/kg/1HLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		IVIEM* -,453,1985
intratracheal/rat lowest published toxic dose: 1.5 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)ARTODN 74,716,2001
intratracheal/rat lowest published lethal dose: 200 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)BJIMAG 10,9,1953
intratracheal/rat lowest published toxic dose: 1 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		TOLED5 192,286,2010
intratracheal/rat lowest published toxic dose: 5 mg/kgLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		TOLED5 192,286,2010
intravenous/Dog lowest published lethal dose: 20 mg/kgBIJOAK 27,1007,1933
intravenous/mouse lowest published lethal dose: 40 mg/kgJNCIAM 1,241,1940
intravenous/rat lowest published lethal dose: 90 mg/kgJNCIAM 57,509,1976
oral/rat lowest published toxic dose: 120 gm/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes		EPASR* #86940001000,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/domestic animal lowest published toxic concentration: 1000 gm/m3/10D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		EXLRDA 15,409,1989
inhalation/guinea pig lowest published toxic concentration: 28 mg/m3/3W- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes		TXAPA9 68,152,1983
inhalation/hamster lowest published toxic concentration: 3 mg/m3/6H/78W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight		INHTE5 10,699,1998
inhalation/monkey lowest published toxic concentration: 10 mg/m3/818D- intermittentLung, Thorax, or Respiration: Other changesTOXID9 72,44,2003
inhalation/mouse lowest published toxic concentration: 160 mg/kg/2W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Autoimmune (multiple organ involvement)		TXCYAC 195,167,2004
inhalation/mouse lowest published toxic concentration: 1475 µg/m3/8H/21W- intermittentLung, Thorax, or Respiration: Other changesENVRAL 39,331,1986
inhalation/mouse lowest published toxic concentration: 4932 µg/m3/24H/39W- continuousEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response		ENVRAL 21,298,1980
inhalation/rat lowest published toxic concentration: 80 mg/m3/26W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response		GTPZAB 31(1),24,1987
inhalation/rat lowest published toxic concentration: 108 mg/m3/6H/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins		TXAPA9 107,350,1991
inhalation/rat lowest published toxic concentration: 58 mg/m3/13W- intermittentLung, Thorax, or Respiration: Other changes

Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count		FCTOD7 29,341,1991
inhalation/rat lowest published toxic concentration: 6.2 mg/m3/6H/6W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response		TOXID9 78,11,2004
inhalation/rat lowest published toxic concentration: 15 mg/m3/79D- intermittentLung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 1,81,2001
inhalation/rat lowest published toxic concentration: 15 mg/m3/26W- intermittentLung, Thorax, or Respiration: Other changesTOXID9 72,44,2003
inhalation/rat lowest published toxic concentration: 0.74 mg/m3/2Y- intermittentLung, Thorax, or Respiration: Other changesTOXID9 72,44,2003
inhalation/rat lowest published toxic concentration: 10 mg/m3/75D- intermittentLung, Thorax, or Respiration: Other changesTOXID9 72,44,2003
inhalation/rat lowest published toxic concentration: 25 mg/m3/5D- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response		TOXID9 90,213,2006
inhalation/rat lowest published toxic concentration: 96 mg/m3/5D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOLED5 186,152,2009
intratracheal/rat lowest published toxic dose: 21.75 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,105,2008
intratracheal/rat lowest published toxic dose: 144 mg/kg/28D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,105,2008
intratracheal/rat lowest published toxic dose: 203 mg/kg/28D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,105,2008
intratracheal/rat lowest published toxic dose: 240 µg/kg/12W- intermittentLung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Decrease in cellular immune response		TXCYAC 175,63,2002
intratracheal/rat lowest published toxic dose: 960 µg/kg/12W- intermittentLung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TXCYAC 175,63,2002
intratracheal/rat lowest published toxic dose: 300 µg/kg/12W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 66,353,2002
intratracheal/rat lowest published toxic dose: 2.88 mg/kg/12W- intermittentBlood: Other changes

Blood: Changes in leukocyte (WBC) count		TXCYAC 175,63,2002
intratracheal/rat lowest published toxic dose: 11.52 mg/kg/12W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes

Blood: Changes in leukocyte (WBC) count		TXCYAC 175,63,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.025 mg/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 68,41,1997
TOXICOLOGY REVIEW31BYAP -,94,1974
TOXICOLOGY REVIEWTOLED5 127,83,2002
TOXICOLOGY REVIEWTOLED5 140-141,223,2003
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWENTOX* -,14,2005
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWMUREAV 681,241,2009
TOXICOLOGY REVIEWPTPAD4 120,35,2008
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWMUTAEX 21,225,2006
TOXICOLOGY REVIEWNEUCL* 18,695,2000
TOXICOLOGY REVIEWMUTAEX 26,185,2011
TOXICOLOGY REVIEWMUTAEX 26,231,2011
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-respirable dust in airtime-weighted average 10 mg/m3/% resp. SiO2+2DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD-total dust in airtime-weighted average 30 mg/m3/2(SiO2+3)DTLWS* 3,33,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3 (respirable), carc, MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3 (resp.), carc, MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.3 mg/m3 (total), MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, (resp), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3 (resp. dust), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3 (respirable), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3 (resp. dust), JAN1999
Occupational Exposure Limit-NORWAYtime-weighted average 0.3 mg/m3 (total dust), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.15 mg/m3, carc 1, resp, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 10 mg/m3 (resp. dust), JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 30 mg/m3 (total dust), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.075 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 mg/m3/(% resp SiO2+2)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 30 mg/m3/(%SiO2+2), total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 250 mppcf/(%SiO2+5)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 mg/m3/(% resp SiO2+2)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 250 mppcf/(%SiO2+5)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, crystalline quartz-air10H Carcinogen time-weighted average 0.05 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6478; Number of Industries 2; Total Number of Facilities 135; Number of Occupations 10; Total Number of Employees Exposed 8927; Total Number of Female Employees Exposed 741
National Occupational Exposure Survey 1983Hazard Code 66495; Number of Industries 254; Total Number of Facilities 53724; Number of Occupations 173; Total Number of Employees Exposed 944731; Total Number of Female Employees Exposed 112888
National Occupational Hazard Survey 1974Hazard Code 66495; Number of Industries 59; Total Number of Facilities 4077; Number of Occupations 82; Total Number of Employees Exposed 81221

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, crystalline in coal mine dust, by IR, 7603
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS, 7600; by IR, 7602
NIOSH CURRENT INTELLIGENCE BULLETIN 36, 1981
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-125G
OSHA ANALYTICAL METHOD #ID142

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