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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyrethrum

RTECS #

UR4200000

CAS #

8003-34-7

Updated

September 201

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Buhach
Chrysanthemum cinerareaefolium
Cinerin I or II
Dalmation insect flowers
Firmotox
Insect powder
Jasmolin I or II
Prentox pyrethrum extract
Pyrenone
Pyrethrin I or II
Pyrethrins
Pyrethrum (ACGIH:OSHA)
Pyrethrum (insecticide)
Pyrethrum powder other than pyrethrins
Pyrocide
Pyronyl
Trieste flowers

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JTEHD6 10,111,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/mouse lethal dose (50 percent kill): 2500 mg/kgHBPTO* 1,114,2001
intraperitoneal/guinea pig lowest published lethal dose: 50 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		PSEBAA 34,135,1936
intraperitoneal/mouse lowest published lethal dose: 25 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		PSEBAA 34,135,1936
intraperitoneal/mouse lethal dose (50 percent kill): 333 mg/kgHBPTO* 1,114,2001
intraperitoneal/pig lethal dose (50 percent kill): 102 mg/kgHBPTO* 1,114,2001
intraperitoneal/rat lethal dose (50 percent kill): 189 mg/kgHBPTO* 1,114,2001
intravenous/Dog lethal dose (50 percent kill): 7 mg/kgWRPCA2 3,28,1964
oral/child lowest published lethal dose: 750 mg/kgCMEP** -,1,1956
oral/guinea pig lowest published lethal dose: 1 gm/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		PSEBAA 34,135,1936
oral/human lowest published lethal dose: 1 gm/kg85GYAV -,142,1971
oral/mammal (species unspecified) lethal dose (50 percent kill): 250 mg/kgAMIHAB 14,178,1956
oral/mouse lethal dose (50 percent kill): 370 mg/kgBehavioral: Tremor

Behavioral: Excitement

Behavioral: Ataxia		EVHPAZ 14,15,1976
oral/mouse lethal dose (50 percent kill): 285 mg/kgHBPTO* 1,114,2001
oral/pig lethal dose (50 percent kill): 1500 mg/kgHBPTO* 1,114,2001
oral/quail lethal dose (50 percent kill): 2000 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HBPTO* 1,114,2001
oral/rat lethal dose (50 percent kill): 200 mg/kgGUCHAZ 6,442,1973
parenteral/chicken lethal dose (50 percent kill): 1565 mg/kgHBPTO* 1,114,2001
skin/rabbit lethal dose (50 percent kill): 300 mg/kgEVHPAZ 14,109,1976
skin/rat lethal dose (50 percent kill): 1350 mg/kgYKYUA6 37,1481,1986
subcutaneous/frog lethal dose (50 percent kill): 5.8 mg/kgHBPTO* 1,114,2001
unreported route/domestic bird lethal dose (50 percent kill): 5620 ppmHBPTO* 1,114,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4600 mg/kg/23D- intermittentLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport		TXAPA9 24,298,1973
oral/rat lowest published toxic dose: 2800 mg/kg/7D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes		TOXID9 72,89,2003
oral/rat lowest published toxic dose: 1050 mg/kg/7D- continuousLiver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight		TOXID9 72,89,2003
oral/rat lowest published toxic dose: 2800 mg/kg/7D- continuousEndocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72,89,2003
oral/rat lowest published toxic dose: 2954 mg/kg/7D- continuousEndocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		TXAPA9 214,253,2006
oral/rat lowest published toxic dose: 5908 mg/kg/14D- continuousEndocrine: Changes in thyroid weightTXAPA9 214,253,2006
oral/rat lowest published toxic dose: 95.2 mg/kg/14D- continuousEndocrine: Other changesTXAPA9 214,253,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 134,3,2002
TOXICOLOGY REVIEWBPCEM* 17,237,2003
TOXICOLOGY REVIEWFCTOD7 47,1406,2009
TOXICOLOGY REVIEWMUTAEX 26,231,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,205,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3DTLVS* 3,219,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 1 mg/m3, FEB2006
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 5 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PYRETHRUM-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 65070; Number of Industries 7; Total Number of Facilities 1031; Number of Occupations 11; Total Number of Employees Exposed 11296; Total Number of Female Employees Exposed 1537
National Occupational Hazard Survey 1974Hazard Code 65070; Number of Industries 10; Total Number of Facilities 1081; Number of Occupations 7; Total Number of Employees Exposed 4375

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Pyrethrum, 5008
OSHA ANALYTICAL METHOD #ID-70

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