Registry of Toxic Effects of Chemical Substances (RTECS)

Propene, 1,3-dichloro-

RTECS #

UC8310000

CAS #

542-75-6; 8022-76-2

Updated

September 201

Molecular Weight

110.97

Molecular Formula

C₃H₄Cl₂

Synonyms

1,3-Dichloro-2-propene
1,3-Dichloropropene
1,3-Dichloropropene (ACGIH)
1,3-Dichloropropene, technical grade
1,3-Dichloropropene-1
1,3-Dichloropropylene
3-Chloroallyl chloride
3-Chloropropenyl chloride
alpha,gamma-Dichloropropylene
alpha-Chloroallyl chloride
D-D 92
DD 95
Dorlone II
gamma-Chloroallyl chloride
NCI-C03985
RCRA waste number U084
Telone
Telone II
Telone II soil fumigant

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	49100 µg/L	EMMUEG 13,60,1989
DNA Damage	intraperitoneal/mouse	150 mg/kg	MUREAV 419,13,1998
mutation in mammalian somatic cells	lymphocyte/mouse	3 mg/L	SCIEAS 236,933,1987
mutation in microorganisms	/Salmonella typhimurium	33 µg/plate (+enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms	/Salmonella typhimurium	10 µmol/plate (-enzymatic activation step)	ENMUDM 2,59,1980
mutation in microorganisms	/Salmonella typhimurium	0.004 µmol/L/3D (-enzymatic activation step)	MUREAV 572,98,2005
mutation in microorganisms	/Salmonella typhimurium	50 mg/L/2H (-enzymatic activation step)	EMMUEG 44,329,2004
mutation in microorganisms	/Salmonella typhimurium	100 mg/L/2H (+enzymatic activation step)	EMMUEG 44,329,2004
other mutation test systems	/Escherichia coli	1 mmol/L	MUREAV 203,81,1988
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	5750 ppm	ENMUDM 7,325,1985
sister chromatid exchange	ovary/hamster	900 nmol/L	CNJGA8 22,681,1980

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 60 ppm/6H/5D/2Y	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors	FAATDF 12,418,1989
oral/mouse	lowest published toxic dose: 31200 mg/kg/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Kidney, Ureter, and Bladder: Bladder tumors	NTPTR* NTP-TR-269,1985
oral/mouse	lowest published toxic dose: 15600 mg/kg/104W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors	NTIS** PB85-230449/AS
oral/mouse	lowest published toxic dose: 31200 mg/kg/104W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors	NTIS** PB85-230449/AS
oral/mouse	lowest published toxic dose: 15600 mg/kg/104W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	NTIS** PB85-230449/AS
oral/rat	lowest published toxic dose: 15600 mg/kg/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors	NTPTR* NTP-TR-269,1985
oral/rat	lowest published toxic dose: 15600 mg/kg/104W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors	NTIS** PB85-230449/AS
oral/rat	lowest published toxic dose: 7800 mg/kg/104W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors	NTIS** PB85-230449/AS
oral/rat	lowest published toxic dose: 7800 mg/kg/104W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors	NTIS** PB85-230449/AS

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 400 ppm/7H		AIHAAP 38,217,1977
inhalation/human	lowest published toxic concentration: 1500 ppm	Lung, Thorax, or Respiration: Cough	VCVGH* -,474,1990
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 3.88 gm/m³/4H		FEREAC 65,1869,2000
inhalation/mouse	lethal concentration (50 percent kill): 3220 mg/m³/2H		VCVGH* -,473,1990
inhalation/rat	Lowest published lethal concentration: 1000 ppm/2H	Eye: Lacrimation	AIHAAP 38,217,1977
intraperitoneal/mouse	lowest published toxic dose: 100 mg/kg	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	CRTOEC 13,1096,2000
intraperitoneal/mouse	lowest published lethal dose: 700 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TOXID9 1,90,2001
intraperitoneal/mouse	lowest published lethal dose: 700 mg/kg		TOXID9 1,90,2001
intraperitoneal/rat	lethal dose (50 percent kill): 175 mg/kg		TOXID9 5,2,1985
oral/mammal (species unspecified)	lethal dose (50 percent kill): 224 mg/kg		FEREAC 65,1869,2000
oral/mouse	lethal dose (50 percent kill): 640 mg/kg		ENTOX* -,11,2005
oral/rat	lethal dose (50 percent kill): 470 mg/kg		ENTOX* -,11,2005
skin/rabbit	lethal dose (50 percent kill): 333 mg/kg		FEREAC 65,1869,2000
skin/rat	lethal dose (50 percent kill): 775 mg/kg		FMCHA2 -,C103,1991

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 90 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 11,207,1988
inhalation/rat	lowest published toxic concentration: 90 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 11,207,1988
oral/Dog	lowest published toxic dose: 3731 mg/kg/13W- continuous	Blood: Microcytosis with or without anemia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	RTOPDW 30,233,1999
oral/Dog	lowest published toxic dose: 5460 mg/kg/1Y- continuous	Blood: Microcytosis with or without anemia Blood: Changes in bone marrow not included in above Nutritional and Gross Metabolic: Weight loss or decreased weight gain	RTOPDW 30,233,1999
oral/mouse	lowest published toxic dose: 1365 mg/kg/13W- continuous	Cardiac: Changes in heart weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 32,224,1996
oral/rat	lowest published toxic dose: 455 mg/kg/26W- intermittent	Gastrointestinal: Changes in structure or function of exocrine pancreas Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	GISAAA 39(1),94,1974
oral/rat	lowest published toxic dose: 1365 mg/kg/13W- continuous	Gastrointestinal: Alteration in gastric secretion Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 32,224,1996
unreported route/rat	lowest published toxic dose: 750 mg/kg/30D- intermittent	Liver: Other changes Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	TOXID9 78,115,2004
unreported route/rat	lowest published toxic dose: 1500 mg/kg/60D- intermittent	Liver: Other changes Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	TOXID9 78,115,2004

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 71,933,1999
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		ENTOX* -,11,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		BCLPT* 96,131,2005
TOXICOLOGY REVIEW		FEREAC 73,8212,2008
TOXICOLOGY REVIEW		MUREAV 654,114,2008
TOXICOLOGY REVIEW		HUTOX* -,561,1996

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,151,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (4.5 mg/m³), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA	TRK-TMW 0.11 ppm (0.5 mg/m³);KZW 0.44 ppm (2 mg/m³), skin, sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (4.6 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (5 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (5 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (5 mg/m³), skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (4.5 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (4.6 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.11 ppm (0.5 mg/m³), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-DICHLOROPROPENE-air	8H Carcinogen time-weighted average 1 ppm (Sk)	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code X3912; Number of Industries 3; Total Number of Facilities 48; Number of Occupations 14; Total Number of Employees Exposed 2162; Total Number of Female Employees Exposed 33

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110765/AS)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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