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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Propanol, 2,3-epoxy-

RTECS #

UB4375000

CAS #

556-52-5

Updated

September 201

Molecular Weight

74.09

Molecular Formula

C3H6O2

Synonyms

2,3-Epoxy-1-propanol (ACGIH:OSHA)
2,3-Epoxypropanol
3-Hydroxy-1,2-epoxypropane
Epihydrin alcohol
Glycide
Glycidol
Glycidol (ACGIH:OSHA)
Glycidyl alcohol
Methanol, oxiranyl-
NCI-C55549

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 2 mg/24H severe85JCAE -,769,1986
skin /rabbit 558 mg/3D moderateAMIHAB 14,250,1956
skin /rabbit 100 mg/24H moderate85JCAE -,769,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human400 µmol/LMUREAV 91,243,1981
Cytogenetic Analysisintraperitoneal/rat320 mg/kgFCTOD7 22,665,1984
Cytogenetic Analysisoral/rat600 mg/kgFCTOD7 22,665,1984
Cytogenetic Analysisovary/hamster12500 µg/LNTPTR* NTP-TR-374,1990
DNA Damageovary/hamster20 mg/L/3HFCTOD7 45,41,2007
DNA Damageother cell types/mouse0.31 mmol/LMUREAV 715,25,2011
DNA repair/Escherichia coli10 gm/LMUREAV 130,141,1984
gene conversion and mitotic recombination/Saccharomyes cerevisiae2500 ppmJJIND8 62,901,1979
heritable translocation testoral/Drosophila melanogaster1230 ppmNTPTR* NTP-TR-374,1990
morphological transformembryo/hamster10 µg/LIJCNAW 19,642,1977
morphological transformfibroblast/mouse0.001 pph/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in mammalian somatic cellslymphocyte/mouse1250 µg/kgNTPTR* NTP-TR-374,1990
mutation in mammalian somatic cellslung/hamster1 µmol/LCRNGDP 11,497,1990
mutation in microorganisms/Neurospora crassa500 mmol/L (-enzymatic activation step)GENTAE 40,890,1955
mutation in microorganisms/Klebsiella pneumoniae200 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Escherichia coli500 µmol/L (-enzymatic activation step)TOLED5 4,103,1979
other mutation test systems/Escherichia coli1 mmol/LMUREAV 231,205,1990
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster3690 ppmNTPTR* NTP-TR-374,1990
sister chromatid exchangelymphocyte/human50 µmol/LMUREAV 91,243,1981
sister chromatid exchangeovary/hamster10100 µg/LNTPTR* NTP-TR-374,1990
sister chromatid exchangelung/hamster1250 µmol/LMUREAV 249,55,1991
specific locus testother cell types/mouse30 gm/L/24HEMMUEG 45,80,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 500 mg/kg (5D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)BCSTB5 1,523,1973
oral/mouse 2 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTEHD6 9,87,1982
oral/mouse 6825 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NTP-TR-374,1990
oral/rat 180 mg/kg (12D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)NATUAS 226,87,1970
oral/rat 18200 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		NTPTR* NTP-TR-374,1990

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 25750 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors		NTPTR* NTP-TR-374,1990
oral/mouse lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors		NTIS** PB90-259094
oral/mouse lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors		NTIS** PB90-259094
oral/rat lowest published toxic dose: 19312.5 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors		NTIS** PB90-259094
oral/rat lowest published toxic dose: 19312.5 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors		NTIS** PB90-259094
oral/rat lowest published toxic dose: 38625 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors		NTPTR* NTP-TR-374,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 450 ppm/4HLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes		AMIHAB 14,250,1956
inhalation/mouse lethal concentration (50 percent kill): 1069 mg/m3/4HBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease		TPKVAL 15,97,1979
inhalation/mouse lowest published toxic concentration: 100 mg/m3/4HTPKVAL 15,97,1979
inhalation/rat lowest published toxic concentration: 100 mg/m3/4HTPKVAL 15,97,1979
inhalation/rat lethal concentration (50 percent kill): 1260 mg/m3/4HTPKVAL 15,97,1979
inhalation/rat lethal concentration (50 percent kill): 580 ppm/8HLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes		AMIHAB 14,250,1956
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgPSEBAA 35,98,1936
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgFCTXAV 19,347,1981
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation		TPKVAL 15,97,1979
oral/mouse lethal dose (50 percent kill): 431 mg/kgGTPZAB 24(3),42,1980
oral/mouse lethal dose (50 percent kill): 431 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease		TPKVAL 15,97,1979
oral/rat lethal dose (50 percent kill): 420 mg/kgFCTXAV 19,347,1981
skin/rabbit lethal dose (50 percent kill): 1980 mg/kgAMIHAB 14,250,1956

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 125 mg/m3/4H/17W- intermittentBrain and Coverings: Recordings from specific areas of CNSGTPZAB 24(3),42,1980
inhalation/rat lowest published toxic concentration: 125 mg/m3/4H/17W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Other changes		GTPZAB 24(3),42,1980
oral/mouse lowest published toxic dose: 9600 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-374,1990
oral/mouse lowest published toxic dose: 27300 mg/kg/13W- intermittentBrain and Coverings: Demyelination

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTPTR* NTP-TR-374,1990
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Immunological Including Allergic: Decrease in cellular immune response		NTPTR* IMM-91019
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentImmunological Including Allergic: Decreased immune response

Immunological Including Allergic: Increased immune response		NTPTR* IMM-91019
oral/mouse lowest published toxic dose: 350 mg/kg/14D- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increase in cellular immune response		NTPTR* IMM-91019
oral/rat lowest published toxic dose: 9600 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-374,1990
oral/rat lowest published toxic dose: 36400 mg/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Other changes		NTPTR* NTP-TR-374,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 77,564,2000
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 751,49,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (150 mg/m3)DTLVS* 3,121,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (76 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIATRK -TMW 50 ppm (150 mg/m3);KZW 50 ppm (150 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (6.2 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.2 ppm (1 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (6.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 25 ppm (75 mg/m3), C2 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 0.2 ppm (1 mg/m3), NOV2011
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (75 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (75 mg/m3);short term exposure limit 100 ppm (300 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (76 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (6 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (150 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (150 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (150 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (150 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCIDOL-air10H time-weighted average 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 35120; Number of Industries 3; Total Number of Facilities 88; Number of Occupations 10; Total Number of Employees Exposed 4872; Total Number of Female Employees Exposed 580

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Glycidol, 1608
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000

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