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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,2-epoxy-3-phenoxy-

RTECS #

TZ3675000

CAS #

122-60-1

Updated

September 201

Molecular Weight

150.19

Molecular Formula

C9H10O2

Synonyms

(Phenoxymethyl)oxirane
1,2-Epoxy-3-phenoxypropane
2,3-Epoxypropylphenyl ether
3-Phenoxy-1,2-epoxypropane
Ageflex PGE
Benzene, (2,3-epoxypropoxy)-
Ether, 2,3-epoxypropyl phenyl
Ether, phenylglycidyl
Fenyl-glycidylether (Czech)
Glycidyl phenyl ether
Heloxy WC-63
Oxirane, (phenoxymethyl)-
PGE (OSHA)
Phenol glycidyl ether
Phenol-glycidaether (German)
Phenoxypropene oxide
Phenoxypropylene oxide
Phenyl 2,3-epoxypropyl ether
Phenyl glycidyl ether
Phenyl glycidyl ether (ACGIH:OSHA)
Phenylglycydyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 111 mg mildAMIHAB 14,250,1956
eye /rabbit 250 µg/24H severe85JCAE -,776,1986
skin /rabbit 10 mg/24H open irritation test severeAMIHBC 10,61,1954
skin /rabbit 20 mg/24H moderate85JCAE -,776,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
host-mediated assaySalmonella typhimurium/mouse2500 mg/kgMUREAV 67,9,1979
morphological transformembryo/hamster6250 µg/LMUREAV 67,9,1979
mutation in microorganisms/Klebsiella pneumoniae100 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)MUREAV 67,9,1979
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
other mutation test systems/Escherichia coli300 µmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster400 µmol/LMUREAV 249,55,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 11 ppm/6H (19D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)TXAPA9 64,204,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 12 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors		AJPAA4 111,140,1983
inhalation/rat lowest published toxic concentration: 1092 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		TOXID9 72,27,2003
inhalation/rat lowest published toxic concentration: 728 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		TOXID9 72,27,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >100 ppm/4HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 14,250,1956
inhalation/rat lethal concentration (50 percent kill): >100 ppm/8HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 14,250,1956
oral/mouse lethal dose (50 percent kill): 1400 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia		AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 3850 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia		AMIHAB 14,250,1956
skin/rabbit lethal dose (50 percent kill): 1500 µL/kgAMIHBC 10,61,1954
subcutaneous/mouse lethal dose (50 percent kill): 760 mg/kgAutonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)ARZNAD 15,1355,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 ppm/6H/90D- intermittentSkin and Appendages: Other: HairJTEHD6 3,859,1977
inhalation/rat lowest published toxic concentration: 728 mg/kg/2Y- intermittentOlfaction: Other olfaction effectsTOXID9 72,27,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 47,237,1989
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1525,1999
TOXICOLOGY REVIEWAJOGAH 113,130,1972
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUTAEX 25,3,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (62 mg/m3)DTLVS* 3,206,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (6.1 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (3.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (6 mg/m3), C2 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 1 ppm (5 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (60 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (6.1 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.61 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.6 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (60 mg/m3);short term exposure limit 15 ppm (90 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (6 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (62 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL GLYCIDYL ETHER-airCarcinogen ceiling concentration 1 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 57280; Number of Industries 15; Total Number of Facilities 355; Number of Occupations 18; Total Number of Employees Exposed 10551; Total Number of Female Employees Exposed 4108
National Occupational Hazard Survey 1974Hazard Code 57280; Number of Industries 13; Total Number of Facilities 434; Number of Occupations 12; Total Number of Employees Exposed 8533

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl glycidyl ether, 1619
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978

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