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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Propanediol, dinitrate

RTECS #

TY6300000

CAS #

6423-43-4

Updated

September 201

Molecular Weight

166.11

Molecular Formula

C3H6N2O6

Synonyms

1,2-Propylene glycol dinitrate
PGDN
Propylene dinitrate
Propylene glycol 1,2-dinitrate
Propylene glycol dinitrate
Propylene glycol dinitrate (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildTXAPA9 22,128,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 ppb/6HBehavioral: HeadacheTXAPA9 30,377,1974
inhalation/human lowest published toxic concentration: 1500 ppb/5MEye: Conjunctiva irritationTXAPA9 30,377,1974
intraperitoneal/guinea pig lethal dose (50 percent kill): 402 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainAIHAAP 34,526,1973
intraperitoneal/mouse lethal dose (50 percent kill): 1047 mg/kgLung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section		AIHAAP 34,526,1973
intraperitoneal/rat lethal dose (50 percent kill): 479 mg/kgLung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section		AIHAAP 34,526,1973
intravenous/monkey lowest published lethal dose: 410 mg/kgEye: Ptosis

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting		TXAPA9 22,128,1972
oral/mouse lethal dose (50 percent kill): 1525 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: EKG changes not diagnostic of above

Blood: Methemoglobinemia- Carboxhemoglobinemia		STGNBT -,94,1999
oral/rat lethal dose (50 percent kill): 250 mg/kgLung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section		AIHAAP 34,526,1973
subcutaneous/cat lowest published lethal dose: 200 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia		TXAPA9 15,175,1969
subcutaneous/mouse lethal dose (50 percent kill): 1208 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia		TXAPA9 15,175,1969
subcutaneous/rat lethal dose (50 percent kill): 463 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia		TXAPA9 15,175,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 236 mg/m3/24H/90D- continuousBlood: Pigmented or nucleated red blood cells

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		TXAPA9 22,128,1972
inhalation/guinea pig lowest published toxic concentration: 236 mg/m3/24H/90D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesTXAPA9 22,128,1972
inhalation/monkey lowest published toxic concentration: 236 mg/m3/24H/90D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 22,128,1972
inhalation/rat lowest published toxic concentration: 236 mg/m3/24H/90D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TXAPA9 22,128,1972
skin/rabbit lowest published toxic dose: 73 gm/kg/3W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAIHAAP 34,526,1973

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.34 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 ppm (0.3 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.34 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.02 ppm (0.2 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 ppm (0.14 mg/m3), short term exposure limit 0.06 ppm (0.41 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 ppm (0.3 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 ppm (0.34 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.02 ppm (0.2 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.05 ppm (0.3 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.34 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,05 ppm (0,34 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.7 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.05 ppm (0.35 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.3 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE GLYCOL DINITRATE-air10H time-weighted average 0.05 ppm (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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