Registry of Toxic Effects of Chemical Substances (RTECS)
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Propane, 1,2-dibromo-3-chloro-
RTECS #
TX8750000CAS #
96-12-8; 105567-86-0Updated
July 2013Molecular Weight
236.35Molecular Formula
C3H5Br2ClSynonyms
(R/S)-1,2-Dibromo-3-chloropropane1,2-Dibrom-3-chlor-propan (German)
1,2-Dibromo-3-chloropropane
1,2-Dibromo-3-chloropropane (DOT:OSHA)
1,2-Dibromo-3-chloropropane production-grade
1,2-Dibromo-3-cloro-propano (Italian)
1,2-Dibroom-3-chloorpropaan (Dutch)
1-Chloro-2,3-dibromopropane
3-Chloro-1,2-dibromopropane
BBC 12
DBCP
Dibromchlorpropan (German)
Dibromochloropropane
Fumagon
Fumazone
Fumazone 86
Fumazone 86E
NCI-C00500
Nemabrom
Nemafume
Nemagon
Nemagon 20
Nemagon 206
Nemagon 20G
Nemagon 90
Nemagon soil fumigant
Nemagone
Nemanax
Nemapaz
Nemaset
Nematocide
Nematox
Nemazon
OS 1897
Oxy DBCP
Propane, 1-chloro-2,3-dibromo-
RCRA waste number U066
SD 1897
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 1% | mild | TXAPA9 3,545,1961 |
| skin /rabbit | 10 gm | severe | TXAPA9 3,545,1961 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | oral/rat | 3650 µg/kg/5D | TXAPA9 48,A46,1979 |
| Cytogenetic Analysis | ovary/hamster | 50 mg/L | SCIEAS 236,933,1987 |
| Cytogenetic Analysis | lung/hamster | 200 µmol/L | MUREAV 78,177,1980 |
| DNA Damage | intraperitoneal/mouse | 100 mg/kg | MUREAV 419,13,1998 |
| DNA Damage | other cell types/rabbit | 300 µmol/L | MUREAV 285,303,1993 |
| DNA Damage | other cell types/rabbit | 30 µmol/L | MUREAV 285,303,1993 |
| DNA Damage | intraperitoneal/guinea pig | 40.2 mg/kg | TXCYAC 58,133,1989 |
| DNA Damage | testis/rat | 173 mg/L | CBTOE2 1(3),181,1985 |
| DNA Damage | intraperitoneal/rat | 35 mg/kg | CBTOE2 1(3),181,1985 |
| DNA Damage | intraperitoneal/rat | 1182 µg/kg | CRTOEC 4,528,1991 |
| DNA Damage | liver/rat | 5 µmol/L | CRNGDP 10,49,1989 |
| DNA inhibition | HeLa cell/human | 10 mmol/L | MUREAV 92,427,1982 |
| DNA repair | /Escherichia coli | 20900 µg/disc | BECTA6 14,8,1975 |
| Dominant Lethal Test | oral/rat | 50 mg/kg/5D-continuous | MUREAV 77,71,1980 |
| heritable translocation test | oral/Drosophila melanogaster | 200 ppm | ENMUDM 7,349,1985 |
| micronucleus test | oral/mouse | 51.4 mg/kg/2D- intermittent | GISAAA 12,41,1993 |
| micronucleus test | oral/rat | 12.68 mg/kg/4D- intermittent | GISAAA 12,41,1993 |
| micronucleus test | oral/mouse | 20.4 mg/kg/4D- intermittent | GISAAA 12,41,1993 |
| micronucleus test | oral/rat | 75 mg/kg | MUREAV 234,129,1990 |
| micronucleus test | intraperitoneal/mouse | 50 mg/kg | MUREAV 389,3,1997 |
| morphological transform | embryo/hamster | 7 mg/L | CBTOE2 3,391,1987 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 83700 µg/L | SCIEAS 236,933,1987 |
| mutation in microorganisms | /Salmonella typhimurium | 100 mg/L/2H (+enzymatic activation step) | EMMUEG 44,329,2004 |
| mutation in microorganisms | /Salmonella typhimurium | 200 mg/L/2H (-enzymatic activation step) | EMMUEG 44,329,2004 |
| mutation in microorganisms | lymphocyte/mouse | 20 mg/L (+enzymatic activation step) | CBTOE2 3,391,1987 |
| mutation in microorganisms | /Salmonella typhimurium | 10 nL/well (+enzymatic activation step) | STEVA8 11,223,1979 |
| mutation in microorganisms | /Salmonella typhimurium | 500 ng/plate (-enzymatic activation step) | ENMUDM 7(Suppl 3),15,1985 |
| mutation in microorganisms | /Bacillus subtilis | 1 nmol/plate (-enzymatic activation step) | MSERDS 5,93,1981 |
| other mutation test systems | /Escherichia coli | 50 mg/L | MUREAV 131,101,1984 |
| sex chromosome loss and nondisjunction | inhalation/Drosophila melanogaster | 17700 ppb/3H-continuous | ENMUDM 4,681,1982 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 100 ppm/3D | HCKHDV 5(5),7,1984 |
| sister chromatid exchange | ovary/hamster | 10 mg/L | SCIEAS 236,933,1987 |
| sister chromatid exchange | lung/hamster | 500 µmol/L | MUREAV 78,177,1980 |
| specific locus test | intraperitoneal/mouse | 106 mg/kg | MUREAV 174,145,1986 |
| sperm morphology | oral/rat | 3650 µg/kg/5D | TXAPA9 48,A46,1979 |
| sperm morphology | oral/rabbit | 375 mg/kg/10W- intermittent | FAATDF 6,628,1986 |
| Unscheduled DNA Synthesis | intraperitoneal/mouse | 100 mg/kg | MUREAV 68,169,1979 |
| Unscheduled DNA Synthesis | intraperitoneal/rat | 150 mg/kg | MUREAV 203,135,1988 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 10 ppm/6H (4W male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 3,104,1983 |
| inhalation/rat | 1 ppm/6H (4W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FAATDF 3,104,1983 |
| inhalation/rabbit | 1 ppm/6H (70D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FAATDF 2,241,1982 |
| inhalation/rabbit | 10 ppm/6H (40D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | FAATDF 2,241,1982 |
| intraperitoneal/rat | 20090 µg/kg (1D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male Reproductive: Specific developmental abnormalities: Urogenital system | CRTOEC 4,528,1991 |
| oral/rat | 200 mg/kg (1D male) | Reproductive: Other effects on male | TOXID9 4,135,1984 |
| oral/rat | 500 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BECTA6 21,483,1979 |
| oral/rat | 250 mg/kg (5D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | MUREAV 101,321,1982 |
| oral/rat | 50 mg/kg (5D male) | Reproductive: Effects on embryo or fetus: Fetal death | MUREAV 77,71,1980 |
| oral/rat | 375 mg/kg (75D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | HYSAAV 36(1-3),344,1971 |
| oral/rabbit | 92657 µg/kg (10W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 6,638,1986 |
| oral/mouse | 875 mg/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | NTIS** #PB85118644/AS |
| oral/mouse | 100 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB85118644/AS |
| oral/mouse | 100 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB85118644/AS |
| subcutaneous/rat | 1 mg/kg (24W male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | BIREBV 31,454,1984 |
| subcutaneous/rat | 50 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ANDRDQ 23,363,1991 |
| subcutaneous/rat | 33 mg/kg (1D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TXAPA9 71,294,1983 |
| subcutaneous/rat | 19 mg/kg (19D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | TXAPA9 90,299,1987 |
| subcutaneous/rat | 40 mg/kg (1D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 79,54,1985 |
| unreported route/rat | 100 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | GISAAA 40(6),101,1975 |
| unreported route/rat | 150 mg/kg (14-19D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects | HBPTO* 1,737,2001 |
| unreported route/rat | 150 mg/kg (16-19D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects | HBPTO* 1,737,2001 |
| unreported route/rat | 150 mg/kg (18-19D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects | HBPTO* 1,737,2001 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 600 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | JCROD7 98,75,1980 |
| inhalation/mouse | toxic concentration (other than lowest): 3 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | JCROD7 98,75,1980 |
| inhalation/mouse | toxic concentration (other than lowest): 600 ppb/6H/76W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors | EVHPAZ 47,365,1983 |
| inhalation/mouse | toxic concentration (other than lowest): 600 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors | NTPTR* NTP-TR-206,1982 |
| inhalation/mouse | toxic concentration (other than lowest): 3 ppm/6H/76W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors | NTPTR* NTP-TR-206,1982 |
| inhalation/mouse | lowest published toxic concentration: 136.8 mg/kg/76W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma | NTIS** PB82-225632 |
| inhalation/mouse | lowest published toxic concentration: 37.08 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | NTIS** PB82-225632 |
| inhalation/rat | lowest published toxic concentration: 18.54 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | NTIS** PB82-225632 |
| inhalation/rat | lowest published toxic concentration: 15.45 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors | NTIS** PB82-225632 |
| inhalation/rat | toxic concentration (other than lowest): 600 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors | NTPTR* NTP-TR-206,1982 |
| inhalation/rat | toxic concentration (other than lowest): 3 ppm/6H/84W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors | NTPTR* NTP-TR-206,1982 |
| inhalation/rat | toxic concentration (other than lowest): 600 ppb/6H/76W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors | EVHPAZ 47,365,1983 |
| inhalation/rat | toxic concentration (other than lowest): 3 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | BJCAAI 42,772,1980 |
| inhalation/rat | lowest published toxic concentration: 600 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | BJCAAI 42,772,1980 |
| oral/mouse | lowest published toxic dose: 49 gm/kg/47W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NCITR* NCI-TR-28,1978 |
| oral/rat | lowest published toxic dose: 5475 mg/kg/73W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors | NCITR* NCI-TR-28,1978 |
| oral/rat | toxic dose: 9280 mg/kg/64W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors | NCITR* NCI-TR-28,1978 |
| skin/mouse | lowest published toxic dose: 100 gm/kg/74W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | JJIND8 63,1433,1979 |
| subcutaneous/rat | lowest published toxic dose: 240 mg/kg/12W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | TOLED5 31(Suppl),202,1986 |
| subcutaneous/rat | toxic dose: 240 mg/kg/12W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | TOLED5 31(Suppl),202,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 103 ppm/8H | FEPRA7 15,448,1956 | |
| inhalation/rat | lethal concentration (50 percent kill): 98 mg/m3/4H | VCVGH* -,654,1990 | |
| intraperitoneal/guinea pig | lowest published lethal dose: 40 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXCYAC 58,133,1989 |
| intraperitoneal/hamster | lowest published lethal dose: 161 mg/kg | TXCYAC 58,133,1989 | |
| intraperitoneal/mouse | lowest published toxic dose: 80.4 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXCYAC 58,133,1989 |
| intraperitoneal/mouse | lowest published lethal dose: 120 mg/kg | TXCYAC 58,133,1989 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 123 mg/kg | MUREAV 68,169,1979 | |
| intraperitoneal/rat | lowest published toxic dose: 40.2 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXCYAC 58,133,1989 |
| intraperitoneal/rat | lowest published lethal dose: 80.4 mg/kg | TXCYAC 58,133,1989 | |
| intraperitoneal/rat | lowest published toxic dose: 40 mg/kg | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | CHIRA* 7,359,1995 |
| oral/chicken | lethal dose (50 percent kill): 60 mg/kg | VCVGH* -,654,1990 | |
| oral/guinea pig | lethal dose (50 percent kill): 150 mg/kg | PCOC** -,797,1966 | |
| oral/mouse | lethal dose (50 percent kill): 257 mg/kg | GUCHAZ 6,172,1973 | |
| oral/rabbit | lethal dose (50 percent kill): 180 mg/kg | VCVGH* -,654,1990 | |
| oral/rat | lowest published toxic dose: 100 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | VCVGH* -,654,1990 |
| oral/rat | lethal dose (50 percent kill): 170 mg/kg | TXAPA9 3,545,1961 | |
| skin/rabbit | lethal dose (50 percent kill): 1400 mg/kg | TXAPA9 3,545,1961 | |
| subcutaneous/rat | lethal dose (50 percent kill): 100 mg/kg | TXCYAC 27,287,1983 | |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Kidney, Ureter, and Bladder: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 1,881,2001 |
| subcutaneous/rat | lowest published toxic dose: 100 mg/kg | Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TXAPA9 59,84,1981 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic dose: 12 ppm/7H/70D- intermittent | Related to Chronic Data: Changes in testicular weight | TXAPA9 3,545,1961 |
| inhalation/mouse | lowest published toxic concentration: 5 ppm/6H/13W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-206,1982 |
| inhalation/rat | lowest published toxic dose: 12 ppm/7H/70D- intermittent | Related to Chronic Data: Changes in testicular weight | TXAPA9 3,545,1961 |
| inhalation/rat | lowest published toxic dose: 10 ppm/7H/70D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TXAPA9 3,545,1961 |
| inhalation/rat | lowest published toxic concentration: 25 ppm/6H/13W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in bone marrow not included in above | NTPTR* NTP-TR-206,1982 |
| inhalation/rat | lowest published toxic concentration: 10 ppm/24H/14D- continuous | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | INHEAO 20,315,1982 |
| intraperitoneal/rat | lowest published toxic dose: 160 mg/kg/2D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Other changes | TOLED5 8,317,1981 |
| oral/mouse | lowest published toxic dose: 11940 mg/kg/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NCITR* NCI-TR-28,1978 |
| oral/rat | lowest published toxic dose: 3150 mg/kg/45D- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Blood: Changes in spleen | MZUZA8 1(1),64,1970 |
| oral/rat | lowest published toxic dose: 2025 mg/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 3,545,1961 |
| oral/rat | lowest published toxic dose: 602 mg/kg/64D- continuous | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 13,804,1989 |
| parenteral/rat | lowest published toxic dose: 350 mg/kg/4D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TOXID9 1,72,2001 |
| parenteral/rat | lowest published toxic dose: 350 mg/kg/4D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | REPTED 17,263,2003 |
| parenteral/rat | lowest published toxic dose: 350 mg/kg/4D- intermittent | Endocrine: Change in LH Endocrine: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | REPTED 17,263,2003 |
| parenteral/rat | lowest published toxic dose: 400 mg/kg/4D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | REPTED 17,263,2003 |
| subcutaneous/rat | lowest published toxic dose: 350 mg/kg/4D- intermittent | Endocrine: Change in gonadotropins Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOSCF2 76,418,2003 |
| subcutaneous/rat | lowest published toxic dose: 2400 mg/kg/12W- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 175 mg/kg/1W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BIREBV 31,454,1984 |
| subcutaneous/rat | lowest published toxic dose: 912.5 mg/kg/26W- intermittent | Endocrine: Change in LH Related to Chronic Data: Changes in testicular weight | BIREBV 31,454,1984 |
| subcutaneous/rat | lowest published toxic dose: 4562 mg/kg/26W- intermittent | Endocrine: Change in gonadotropins Related to Chronic Data: Changes in prostate weight | BIREBV 31,454,1984 |
| subcutaneous/rat | lowest published toxic dose: 912.5 mg/kg/26W- intermittent | Related to Chronic Data: Changes in testicular weight | BIREBV 31,454,1984 |
| subcutaneous/rat | lowest published toxic dose: 182.5 mg/kg/26W- intermittent | Endocrine: Androgenic | BIREBV 31,454,1984 |
| subcutaneous/rat | lowest published toxic dose: 240 mg/kg/12W- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 540 mg/kg/9W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 1920 mg/kg/32W- intermittent | Tumorigenic: Tumors at site of application | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 2160 mg/kg/36W- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 400 mg/kg/2W- intermittent | Skin and Appendages: Other: Hair | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 600 mg/kg/3W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 2400 mg/kg/12W- intermittent | Blood: Luekopenia Kidney, Ureter, and Bladder: Other changes in urine composition Related to Chronic Data: Changes in testicular weight | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 6000 mg/kg/30W- intermittent | Tumorigenic: Tumors at site of application | INHEAO 27,49,1989 |
| subcutaneous/rat | lowest published toxic dose: 7200 mg/kg/36W- intermittent | Blood: Normocytic anemia Blood: Changes in leukocyte (WBC) count | INHEAO 27,49,1989 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 20,83,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 15,139,1977 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,479,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMSUDL 7,191,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,479,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,479,1999 |
| TOXICOLOGY REVIEW | TOLED5 127,135,2002 | |
| TOXICOLOGY REVIEW | FAATDF 13,747,1989 | |
| TOXICOLOGY REVIEW | TOLED5 134,17,2002 | |
| TOXICOLOGY REVIEW | TOLED5 135,167,2002 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | ENTOX* -,546,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,793,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,193,2005 | |
| TOXICOLOGY REVIEW | BCLPT* 96,131,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | JTPAE7 17,69,2004 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | MUREAV 681,3,2009 | |
| TOXICOLOGY REVIEW | MUREAV 590,1,2005 | |
| TOXICOLOGY REVIEW | REPTED 26,13,2008 | |
| TOXICOLOGY REVIEW | MUREAV 751,49,2012 | |
| TOXICOLOGY REVIEW | REPTED 33,269,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-DENMARK | time-weighted average 0.001 ppm (0.01 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-HUNGARY | ceiling concentration 0.01 mg/m3, Carcinogen, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.001 ppm (0.01 mg/m3), carc, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-SWEDEN | Group A Carcinogen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | carc 2, JAN2011 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | see Code of Federal Regulations (CFR) 29,1926.1144 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA)-cancer hazard | CFRGBR 29,1910.1044,1987 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DIBROMO-3-CHLOROPROPANE-air | Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1044 | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code M2705; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 6; Total Number of Employees Exposed 176 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Sperm morphology-human | |
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Studies (inhal);clear evidence:rat | |
| NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
| NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-206,1982 | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division