Registry of Toxic Effects of Chemical Substances (RTECS)
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Polychlorinated biphenyl (aroclor 1254)
RTECS #
TQ1360000CAS #
11097-69-1Updated
December 2013Molecular Weight
N/RMolecular Formula
N/RSynonyms
Arochlor 1254Aroclor 1254
Chlorierte biphenyle, chlorgehalt 54% (German)
Chlorodiphenyl (54% chlorine)
Chlorodiphenyl (54% chlorine) (ACGIH,OSHA)
Chlorodiphenyl (54% Cl)
Clorodifenili, cloro 54% (Italian)
Diphenyle chlore, 54% de chlore (French)
NCI-C02664
PCB (OSHA)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | intraperitoneal/other fish | 50 mg/kg | CBPCEE 82,489,1985 |
| Cytogenetic Analysis | embryo/chicken | 1 mg/L/48H | REPTED 19,79,2004 |
| DNA adduct | liver/human | 60 µmol/L/24H | TXAPA9 188,81,2003 |
| DNA Damage | oral/rat | 1295 mg/kg | BSIBAC 57,407,1981 |
| DNA Damage | intraperitoneal/rat | 500 mg/kg | BSIBAC 57,407,1981 |
| DNA Damage | liver/rat | 300 µmol/L | SinJF# 26OCT1982 |
| micronucleus test | intraperitoneal/other fish | 50 mg/kg | CYTBAI 47,147,1986 |
| morphological transform | oral/rat | 25 ppm/2Y-continuous | EVHPAZ 60,89,1985 |
| morphological transform | fibroblast/mouse | 5 mg/L/21D (-enzymatic activation step) | EMMUEG 37,231,2001 |
| sperm morphology | oral/other insects | 808 mg | CYTBAI 11,167,1974 |
| Unscheduled DNA Synthesis | liver/rat | 20 mg/L | CNREA8 42,3010,1982 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 250 mg/kg (15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Biochemical and metabolic | IJBOBV 25,1209,1993 |
| oral/mouse | 59400 µg/kg (3D pre-21D after birth) | Reproductive: Effects on newborn: Behavioral | NTOTDY 3,5,1981 |
| oral/rabbit | 350 mg/kg (1-28D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death | EVPHBI 1,67,1971 |
| oral/rabbit | 280 mg/kg (1-28D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | BECTA6 6,120,1971 |
| oral/mammal (species unspecified) | 14 mg/kg (30D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | TOXID9 4,83,1984 |
| oral/rat | 380 mg/kg (6-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system | TOXID9 15,243,1995 |
| oral/rat | 38 mg/kg (6-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system | TOXID9 15,157,1995 |
| oral/rat | 152 mg/kg (6-22D preg/21D after birth) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 15,157,1995 |
| oral/rat | 38 mg/kg (6-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Eye, ear | TOXID9 30,25,1996 |
| oral/rat | 35 mg/kg (10-16D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system | TXAPA9 136,269,1996 |
| oral/rat | 320 µg/kg (5D after birth) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | ENVRAL 66,52,1994 |
| oral/rat | 160 µg/kg (5D after birth) | Reproductive: Effects on newborn: Physical | ENVRAL 66,52,1994 |
| oral/rat | 222 mg/kg (6-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system | TXAPA9 174,188,2001 |
| oral/rat | 462.5 mg/kg (1D preg-15D after birth) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | BECTA6 48,715,1992 |
| oral/rat | 4 gm/kg (12-16D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TJADAB 21,62A,1980 |
| oral/rat | 192 mg/kg (6D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Delayed effects | ENVRAL 31,76,1983 |
| oral/rat | 148 mg/kg (6-21D preg/21D after birth) | Reproductive: Effects on newborn: Behavioral | FAATDF 33,120,1996 |
| oral/rat | 35 mg/kg (10-16D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TXAPA9 139,252,1996 |
| oral/rat | 90 mg/kg (7-15D pregnant) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | FCTXAV 11,471,1973 |
| oral/rat | 40 mg/kg (5D after birth) | Reproductive: Effects on newborn: Delayed effects | BECTA6 38,946,1987 |
| oral/rat | 750 mg/kg (5D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FCTXAV 13,507,1975 |
| oral/rat | 96 mg/kg (6-21D pregnant) | Reproductive: Effects on newborn: Behavioral | BRREAP 850,87,1999 |
| oral/rat | 304 mg/kg (6-22D preg/21D after birth) | Reproductive: Effects on newborn: Other postnatal measures or effects | HERED3 144,196,2000 |
| oral/mouse | 252 mg/kg (1-21D preg/21D after birth) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Other postnatal measures or effects | NRTXDN 23,375,2002 |
| oral/rat | 396 mg/kg (28D pre-16D after birth) | Reproductive: Specific developmental abnormalities: Gastrointestinal system Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOSCF2 77,315,2004 |
| oral/rat | 228 mg/kg (6-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Effects on newborn: Delayed effects | TOSCF2 68,458,2002 |
| oral/mouse | 222 mg/kg (6-21D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | NRTXDN 23,375,2002 |
| oral/rat | 675 mg/kg (1-22D preg/23D after birth) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOSCF2 77,51,2004 |
| oral/mouse | 360 mg/kg (6-21D preg/21D after birth) | Reproductive: Other effects on female Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NRTXDN 26,183,2005 |
| oral/rat | 125 mg/kg (15-19D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | REPTED 20,521,2005 |
| oral/rat | 44 mg/kg (1-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TOXID9 90,296,2006 |
| oral/rat | 138 mg/kg (6-21D preg/7D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | NETOX* 27,118,2006 |
| oral/rat | 396 mg/kg (28D pre-16D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic | NETEEC 28,74,2006 |
| oral/rat | 43 mg/kg (1D preg-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TOXID9 44,222,2005 |
| oral/rat | 14 mg/kg (2-15D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 66,27,2002 |
| oral/mouse | 90 mg/kg (6-20D pregnant) | Reproductive: Effects on newborn: Behavioral | ARTODN 80,286,2006 |
| oral/rat | 138 mg/kg (6-22D preg/7D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TXAPA9 231,165,2008 |
| oral/rat | 234 mg/kg (5D preg-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system | NRTXDN 32,981,2011 |
| subcutaneous/rat | 90 mg/kg (10-18D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Other postnatal measures or effects | TXCYAC 220,104,2006 |
| subcutaneous/rat | 90 mg/kg (10-18D pregnant) | Reproductive: Effects on newborn: Delayed effects | TXCYAC 220,104,2006 |
| subcutaneous/rat | 270 mg/kg (10-18D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | TOXID9 72,133,2003 |
| subcutaneous/mouse | 300 mg/kg (14D prior to copulation) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | AECTCV 44,72,2003 |
| subcutaneous/rat | 90 mg/kg (10-18D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system | TOLED5 135,S83,2001 |
| unreported route/rat | 144 mg/kg (6D preg-7D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 44,221,2005 |
| unreported route/rat | 228 mg/kg (6D preg-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 66,27,2002 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 500 mg/kg (19D pregnant) | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Lung, Thorax, or Respiration: Tumors | JJIND8 71,157,1983 |
| oral/mouse | lowest published toxic dose: 17 gm/kg/48W- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | JNCIAM 53,547,1974 |
| oral/rat | lowest published toxic dose: 73500 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | EVHPAZ 60,89,1985 |
| oral/rat | toxic dose: 1 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | CNREA8 41,5052,1981 |
| oral/rat | toxic dose: 3 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | CNREA8 41,5052,1981 |
| oral/rat | toxic dose: 4 gm/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | NCITR* NCI-TR-38,1978 |
| skin/mouse | lowest published toxic dose: 4 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | BECTA6 18,552,1977 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/paa | Inhibitor Concentration Low: 1 mg/L/30M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | TXAPA9 245,1,2010 |
| In Vitro/paa | Inhibitor Concentration Low: 30 mg/L/5M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | TXAPA9 245,1,2010 |
| intracerebral/rat | lowest published toxic dose: 24 µg/kg | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TXCYAC 216,140,2005 |
| intraperitoneal/mammal (species unspecified) | lethal dose (50 percent kill): >1250 mg/kg | AECTCV 6,279,1977 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 880 mg/kg | BECTA6 8,245,1972 | |
| intraperitoneal/mouse | lowest published toxic dose: 50 mg/kg | Liver: Changes in liver weight Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | ENVPAF 72,57,1991 |
| intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg | Liver: Other changes Blood: Other changes | ENVPAF 72,57,1991 |
| intraperitoneal/mouse | lowest published toxic dose: 50 mg/kg | Blood: Other changes | ENVPAF 72,57,1991 |
| intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | ENVPAF 72,57,1991 |
| intraperitoneal/mouse | lowest published toxic dose: 500 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXAPA9 71,254,1983 |
| intraperitoneal/non-mammalian species | lowest published toxic dose: 20 mg/kg | Liver: Liver function tests impaired Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TOLED5 136,97,2002 |
| intraperitoneal/non-mammalian species | lowest published toxic dose: 70 mg/kg | Kidney, Ureter, and Bladder: Other changes Biochemical: Metabolism (intermediary): Other proteins | TOLED5 136,97,2002 |
| intraperitoneal/rat | lowest published toxic dose: 500 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | MOPMA3 13,924,1977 |
| intraperitoneal/rat | lowest published toxic dose: 10 mg/kg | Endocrine: Evidence of thyroid hypofunction | ATSUDG 13,440,1989 |
| intravenous/chicken | lowest published toxic dose: 300 mg/kg | Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Effect on mitochondrial function | JBCHA3 255,8275,1980 |
| intravenous/rat | lethal dose (50 percent kill): 358 mg/kg | VCVGK* -,58,1984 | |
| intravenous/rat | lethal dose (50 percent kill): 358 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | FCTXAV 12,63,1974 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 4 gm/kg | AECTCV 6,279,1977 | |
| oral/rat | lethal dose (50 percent kill): 1010 mg/kg | TXAPA9 60,33,1981 | |
| oral/rat | lowest published toxic dose: 300 mg/kg | Liver: Other changes Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | EVHPAZ 109,1163,2001 |
| oral/rat | lowest published toxic dose: 330 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other | ARTODN 78,316,2004 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/domestic animal | lowest published toxic dose: 5 mg/kg/20D- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| intramuscular/domestic animal | lowest published toxic dose: 7500 µg/kg/12W- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| intramuscular/rabbit | lowest published toxic dose: 25 mg/kg/20D- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| intraperitoneal/guinea pig | lowest published toxic dose: 320 mg/kg/13D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Other | CBCPAI 99C,251,1991 |
| intraperitoneal/non-mammalian species | lowest published toxic dose: 320 mg/kg/13D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Other | CBCPAI 99C,251,1991 |
| intraperitoneal/rat | : 60 mg/kg/30D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 44,2040,2006 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Endocrine: Change in LH Endocrine: Change in gonadotropins Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXCYAC 232,170,2007 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Brain and Coverings: Changes in brain weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | NRTXDN 28,490,2007 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXCYAC 241,99,2007 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | REPTED 23,239,2007 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase Biochemical: Metabolism (intermediary): Lipids including transport | BCLPT* 105,92,2009 |
| intraperitoneal/rat | lowest published toxic dose: 30 mg/kg/20D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Metabolism (intermediary): Effect on mitochondrial function Related to Chronic Data: Changes in testicular weight | FCTOD7 47,1733,2009 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | REPTED 27,41,2009 |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg/2W- intermittent | Biochemical: Metabolism (intermediary): Other | BECTA6 19,729,1978 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | REPTED 19,201,2004 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | REPTED 19,201,2004 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | REPTED 20,117,2005 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | REPTED 20,117,2005 |
| intraperitoneal/rat | lowest published toxic dose: 350 mg/kg/7D- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | JTEHD6 4,107,1978 |
| intraperitoneal/wild bird | lowest published toxic dose: 320 mg/kg/13D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Other | CBCPAI 99C,251,1991 |
| oral/domestic bird | lowest published toxic dose: 431 mg/kg/8W- continuous | Autonomic Nervous System: Sympathomimetic Liver: Changes in liver weight Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TXAPA9 53,75,1980 |
| oral/mammal (species unspecified) | lowest published toxic dose: 119 mg/kg/28D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 15,393,1986 |
| oral/mammal (species unspecified) | lowest published toxic dose: 180 mg/kg/17W- continuous | Cardiac: Changes in heart weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 6,279,1977 |
| oral/monkey | lowest published toxic dose: 8365 µg/kg/4.5Y- intermittent | Immunological Including Allergic: Decrease in humoral immune response | FAATDF 16,773,1991 |
| oral/monkey | lowest published toxic dose: 170 mg/kg/2.3Y- intermittent | Eye: Other eye effects Blood: Changes in spleen Skin and Appendages: Other: Nails | TOPADD 14,1,1986 |
| oral/monkey | lowest published toxic dose: 14.6 mg/kg/2Y- intermittent | Endocrine: Other changes | AECTCV 19,939,1990 |
| oral/monkey | lowest published toxic dose: 58.4 mg/kg/2Y- intermittent | Endocrine: Effect on menstrual cycle | AECTCV 19,939,1990 |
| oral/mouse | lowest published toxic dose: 672 mg/kg/28D- continuous | Liver: Changes in liver weight | JTEHD6 5,605,1979 |
| oral/mouse | lowest published toxic dose: 90 mg/kg/15D- continuous | Behavioral: Altered sleep time (including change in righting reflex) Liver: Changes in liver weight Endocrine: Changes in adrenal weight | TXAPA9 40,91,1977 |
| oral/mouse | lowest published toxic dose: 168 mg/kg/2W- continuous | Behavioral: Altered sleep time (including change in righting reflex) Liver: Changes in liver weight | ENPBBC 5,308,1975 |
| oral/mouse | lowest published toxic dose: 672 mg/kg/2W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ENPBBC 5,308,1975 |
| oral/mouse | lowest published toxic dose: 178 mg/kg/14D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BECTA6 12,394,1974 |
| oral/mouse | lowest published toxic dose: 552 mg/kg/14D- continuous | Behavioral: Altered sleep time (including change in righting reflex) Liver: Changes in liver weight | BECTA6 12,394,1974 |
| oral/mouse | lowest published toxic dose: 1965 mg/kg/14D- continuous | Endocrine: Changes in adrenal weight | BECTA6 12,394,1974 |
| oral/mouse | lowest published toxic dose: 3360 mg/kg/7D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BECTA6 12,394,1974 |
| oral/mouse | lowest published toxic dose: 75.6 mg/kg/21D- intermittent | Liver: Changes in liver weight Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXAPA9 188,6,2003 |
| oral/non-mammalian species | lowest published toxic dose: 30 mg/kg/30D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | BIREBV 64,955,2001 |
| oral/non-mammalian species | lowest published toxic dose: 30 mg/kg/15D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | BIREBV 64,955,2001 |
| oral/non-mammalian species | lowest published toxic dose: 102.9 mg/kg/30D- continuous | Endocrine: Androgenic Endocrine: Estrogenic Related to Chronic Data: Changes in ovarian weight | MAERE* 24,179,1988 |
| oral/quail | lowest published toxic dose: 588 mg/kg/12W- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | JTEHD6 51,57,1997 |
| oral/rabbit | lowest published toxic dose: 4200 mg/kg/14W- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Changes in uterine weight | AJPAA4 70,363,1973 |
| oral/rabbit | lowest published toxic dose: 5.94 mg/kg/33D- continuous | Immunological Including Allergic: Decrease in humoral immune response | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 10.26 mg/kg/57D- continuous | Endocrine: Other changes | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 119.7 mg/kg/57D- continuous | Liver: Changes in liver weight Endocrine: Changes in spleen weight | TXAPA9 32,587,1975 |
| oral/rat | lowest published toxic dose: 10 mg/kg/40D- continuous | Endocrine: Evidence of thyroid hypofunction | ENDOAO 121,520,1987 |
| oral/rat | lowest published toxic dose: 10 mg/kg/20D- continuous | Endocrine: Evidence of thyroid hypofunction | ENDOAO 121,520,1987 |
| oral/rat | lowest published toxic dose: 7.5 mg/kg/150D- continuous | Biochemical: Metabolism (intermediary): Other | ENDOAO 121,520,1987 |
| oral/rat | lowest published toxic dose: 8.4 mg/kg/4W- continuous | Endocrine: Evidence of thyroid hyperfunction | VAAZA2 33,213,1980 |
| oral/rat | lowest published toxic dose: 84 mg/kg/4W- continuous | Endocrine: Toxic goiter- hypofunction | VAAZA2 33,213,1980 |
| oral/rat | lowest published toxic dose: 10.5 mg/kg/5W- continuous | Endocrine: Other changes | JEPTDQ 1,587,1978 |
| oral/rat | lowest published toxic dose: 756 mg/kg/18W- continuous | Liver: Tumors Tumorigenic: Facilitates action of known carcinogens | JNCIAM 66,509,1981 |
| oral/rat | lowest published toxic dose: 350 mg/kg/7D- intermittent | Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | EXMPA6 22,376,1975 |
| oral/rat | lowest published toxic dose: 165 mg/kg/11D- intermittent | Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other | CJPPA3 54,23,1976 |
| oral/rat | lowest published toxic dose: 21 mg/kg/7D- continuous | Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | ATSUDG 12,85,1988 |
| oral/rat | lowest published toxic dose: 63 mg/kg/7D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | ATSUDG 12,85,1988 |
| oral/rat | lowest published toxic dose: 33.6 mg/kg/28D- continuous | Liver: Fatty liver degeneration Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | JTEHD6 6,421,1980 |
| oral/rat | lowest published toxic dose: 42 mg/kg/7D- continuous | Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TOXID9 72,313,2003 |
| oral/rat | lowest published toxic dose: 21 mg/kg/7D- continuous | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOXID9 44,420,2005 |
| oral/rat | lowest published toxic dose: 21 mg/kg/7D- continuous | Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other | TOXID9 44,420,2005 |
| oral/rat | lowest published toxic dose: 120 mg/kg/4D- intermittent | Liver: Fatty liver degeneration Endocrine: Hypoglycemia Biochemical: Metabolism (intermediary): Other | TOXID9 78,245,2004 |
| oral/rat | lowest published toxic dose: 180 mg/kg/3D- intermittent | Liver: Other changes Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other proteins | TOXID9 78,246,2004 |
| oral/rat | lowest published toxic dose: 600 mg/kg/4W- intermittent | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 40,68,1997 |
| oral/rat | lowest published toxic dose: 5475 mg/kg/52W- continuous | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins | AECTCV 8,191,1979 |
| oral/rat | lowest published toxic dose: 1652 mg/kg/35W- continuous | Liver: Other changes Liver: Changes in liver weight | AEHLAU 25,354,1972 |
| oral/rat | lowest published toxic dose: 210 mg/kg/20W- continuous | Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Lipids including transport | TXAPA9 37,112,1976 |
| oral/rat | lowest published toxic dose: 105 mg/kg/15W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Musculoskeletal: Other changes | TXCYAC 57,83,1989 |
| oral/rat | lowest published toxic dose: 50400 µg/kg/12W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins | BECTA6 12,669,1974 |
| oral/rat | lowest published toxic dose: 60 mg/kg/20D- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | JTEHD6 3,769,1977 |
| oral/rat | lowest published toxic dose: 70 mg/kg/1W- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BECTA6 12,145,1974 |
| oral/rat | lowest published toxic dose: 1920 µg/kg/4D- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | BECTA6 34,427,1985 |
| oral/rat | lowest published toxic dose: 750 mg/kg/5D- intermittent | Blood: Changes in bone marrow not included in above Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BECTA6 13,14,1975 |
| oral/rat | lowest published toxic dose: 1500 mg/kg/5D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BECTA6 13,14,1975 |
| oral/rat | lowest published toxic dose: 1820 mg/kg/52W- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 1750 mg/kg/10W- intermittent | Endocrine: Changes in pituitary weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 20,288,1993 |
| oral/rat | lowest published toxic dose: 2625 mg/kg/15W- intermittent | Endocrine: Changes in pituitary weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 20,288,1993 |
| oral/rat | lowest published toxic dose: 35 mg/kg/5W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Endocrine: Evidence of thyroid hypofunction | FAATDF 20,288,1993 |
| oral/rat | lowest published toxic dose: 300 mg/kg/30D- intermittent | Endocrine: Effect on menstrual cycle Nutritional and Gross Metabolic: Weight loss or decreased weight gain | CBCPAI 77C ,65,1984 |
| oral/rat | lowest published toxic dose: 632.4 mg/kg/372D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 1055.6 mg/kg/182D- continuous | Musculoskeletal: Other changes | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 309.4 mg/kg/182D- continuous | Behavioral: Change in motor activity (specific assay) | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 3500 mg/kg/5W- intermittent | Liver: Jaundice, other or unclassified Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 66,283,2002 |
| oral/rat | lowest published toxic dose: 350 mg/kg/5W- intermittent | Blood: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | TOXID9 66,283,2002 |
| oral/rat | lowest published toxic dose: 224 mg/kg/7D- intermittent | Endocrine: Other changes | TOXID9 60,380,2001 |
| oral/rat | lowest published toxic dose: 600 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOLED5 161,152,2006 |
| oral/rat | lowest published toxic dose: 1.8 mg/kg/3D- intermittent | Liver: Other changes Endocrine: Other changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 -,167,2008 |
| oral/rat | lowest published toxic dose: 600 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other proteins | TOLED5 161,152,2006 |
| oral/rat | lowest published toxic dose: 56 mg/kg/14D- intermittent | Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXCYAC 177,227,2002 |
| oral/rat | lowest published toxic dose: 42 mg/kg/7D- intermittent | Liver: Changes in liver weight Endocrine: Evidence of thyroid hypofunction | TOSCF2 65,184,2002 |
| oral/rat | lowest published toxic dose: 140 mg/kg/14D- intermittent | Brain and Coverings: Other degenerative changes | NRTXDN 33,16,2012 |
| oral/rat | lowest published toxic dose: 42 mg/kg/7D- continuous | Liver: Other changes Endocrine: Other changes | TXAPA9 248,38,2010 |
| oral/rat | lowest published toxic dose: 42 mg/kg/7D- continuous | Endocrine: Other changes | TXAPA9 248,38,2010 |
| oral/rat | lowest published toxic dose: 60 mg/kg/6D- intermittent | Liver: Other changes Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TXAPA9 248,178,2010 |
| oral/wild bird | lowest published toxic dose: 2800 mg/kg/8W- intermittent | Endocrine: Changes in thyroid weight | BECTA6 8,306,1972 |
| parenteral/duck | lowest published toxic dose: 25 mg/kg/10W- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| skin/rat | lowest published toxic dose: 120 µg/kg/4D- intermittent | Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other | CJPPA3 54,23,1976 |
| subcutaneous/domestic animal | lowest published toxic dose: 20 mg/kg/20D- intermittent | Immunological Including Allergic: Decrease in humoral immune response Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEPOEC 9,283,1989 |
| subcutaneous/rabbit | lowest published toxic dose: 25 mg/kg/20D- intermittent | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Metabolism (intermediary): Other proteins | JEPOEC 9,283,1989 |
| subcutaneous/rat | lowest published toxic dose: 170 mg/kg/5W- intermittent | Endocrine: Other changes Musculoskeletal: Other changes | TOLED5 166,276,2006 |
| subcutaneous/rat | lowest published toxic dose: 210 mg/kg/6W- intermittent | Nutritional and Gross Metabolic: Changes in: Ca | TOLED5 166,276,2006 |
| unreported route/rat | lowest published toxic dose: 210 mg/kg/21D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TOXID9 66,303,2002 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 18,43,1978 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMSUDL 7,322,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMSUDL 7,322,1987 |
| TOXICOLOGY REVIEW | EVHPAZ 1,105,1972 | |
| TOXICOLOGY REVIEW | ARVPAX 14,139,1974 | |
| TOXICOLOGY REVIEW | RREVAH 44,1,1973 | |
| TOXICOLOGY REVIEW | STEVA8 2,305,1974 | |
| TOXICOLOGY REVIEW | BISNAS 20,958,1970 | |
| TOXICOLOGY REVIEW | ENVRAL 5,249,1972 | |
| TOXICOLOGY REVIEW | ARTODN 78,252,2004 | |
| TOXICOLOGY REVIEW | NETEEC 28,260,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,334,2005 | |
| TOXICOLOGY REVIEW | TIHEEC 16,305,2000 | |
| TOXICOLOGY REVIEW | ITODC* -,327,2004 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | MUREAV 681,80,2009 | |
| TOXICOLOGY REVIEW | NTAPM* -,347,1995 | |
| TOXICOLOGY REVIEW | NRTXDN 33,178,2012 | |
| TOXICOLOGY REVIEW | NETOX* 33,911,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg/m3 (skin) | DTLVS* 3,52,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.05 ppm (0.5 mg/m3);KZW 0.5 ppm (5 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-FRANCE | VME 0.5 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.05 ppm (0.7 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.01 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.04 ppm (0.5 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.01 mg/m3;short term exposure limit 0.03 mg/m3, Carcinogen, Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 ppm (0.5 mg/m3), KZG-week 0.4 ppm (4 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIPHENYL (54% Cl)-air | 10H Carcinogen time-weighted average 0.001 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X1181; Number of Industries 5; Total Number of Facilities 170; Number of Occupations 7; Total Number of Employees Exposed 3702; Total Number of Female Employees Exposed 1725 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus | |
| EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Rodent dominant lethal | |
| EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat | NCITR* NCI-TR-38,1978 |
| NIOSH Analytical Method, 1994: Polychlorobiphenyls, 5503; in serum, 8004 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986 | |
| NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division